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Synthesis and thrombolytic activity of fibrinogen fragment related cyclopeptides
Zhao, M; Lin, N; Wang, C; Peng, SQ
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2003-03-10
DOI10.1016/S0960-894X(02)01072-7
13期:5页:961-964
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
英文摘要

In the modification of the fibrinogen fragment related sequences ARPAK, QRPAK GRPAK and KRPAK, the corresponding cyclo-ARPAK, cyclo-QRPAK, cyclo-GRPAK, and cyclo-KRPAK were prepared in the diluted solution. The bioassay in vivo indicated that the thrombolytic potencies of cyclo-ARPAK, cyclo-GRPAK, cyclo-QRPAK, and cyclo-KRPAK were significantly higher than that of ARPAK, QRPAK, GRPAK, and KRPAK. In water, the cyclopeptides were incubated with pepsin or trypsin at 37degreesC for 64 h. There was no degradation product observed, on the other hand, with the same condition, the peptides were completely hydrolyzed in 8 h. The relationships among the rigidity or the conformation and the thrombolytic activity in vivo and the stability to enzyme-induced hydrolysis in vitro of the cyclopeptides were discussed. (C) 2003 Published by Elsevier Science Ltd.

语种英语
WOS记录号WOS:000181563500041
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57302
专题北京大学药学院
作者单位Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhao, M,Lin, N,Wang, C,et al. Synthesis and thrombolytic activity of fibrinogen fragment related cyclopeptides[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2003,13(5):961-964.
APA Zhao, M,Lin, N,Wang, C,&Peng, SQ.(2003).Synthesis and thrombolytic activity of fibrinogen fragment related cyclopeptides.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,13(5),961-964.
MLA Zhao, M,et al."Synthesis and thrombolytic activity of fibrinogen fragment related cyclopeptides".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13.5(2003):961-964.
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