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学科主题: 临床医学
题名:
Relationship of Helicobacter pylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study
作者: Zhou Liya; Lin Sanren; Ding Shigang; Huang Xuebiao; Jin Zhu; Cui Rongli; Meng Lingmei; Li Yuan; Zhang Li; Guo Changji; Xue Yan; Yan Xiu′ e(1); Zhang Jing
关键词: Helicobacter pylori ; gastric cancer ; atrophic gastritis ; intestinal metaplasia
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-04-20
DOI: 10.3760/cma.j.issn.0366-6999.20132494
卷: 127, 期:8, 页:1454-1458
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: INTESTINAL METAPLASIA ; ATROPHIC GASTRITIS ; INFECTION ; RISK ; TRIAL ; CURE
英文摘要:

Background Helicobacter pylori (Hp) is a common and potentially curable cause of gastric mucosa lesion. This study investigated the relationship of Hp infection with histological changes in gastric mucosa and gastric cancer in Hp-positive patients compared with Hp-eradication patients followed up for ten years.

Methods From an initial group of 1 006 adults, 552 Hp-positive subjects were randomly assigned to a treatment group (T; n=276) or a placebo group (P; n=276). In the randomized, double-blind, placebo-controlled, parallel trial, T group subjects received oral doses of omeprazole, amoxicillin and clarithromycin for 1 week; those in the P group received a placebo. One month after treatment ended, a C-13 urea breath test was performed, and Hp was undetectable in 88.89% of the T group. All subjects were followed at 1, 5, 8, and 10 years after treatment, with endoscopy and biopsies for histological examination.

Results Gastric mucosa inflammation was significantly milder in the T group than that in the P group one year after Hp eradication and this persisted for 10 years. Glandular atrophy and intestinal metaplasia (IM) had deteriorated in both groups during ten years. However, the increased score of glandular atrophy at both the gastric antrum and corpus, and IM only at the gastric antrum, in the P group was more obvious than that in the T group. During the 10 years, 9 patients were diagnosed with gastric cancer (2 in the T group; 7 in the P group; P=0.176). When mucosal atrophy was absent at the gastric antrum and corpus When entering the study, the incidence of gastric cancer in the P group (n=6) was much higher than that in the T group (n=0, P=0.013).

Conclusions Hp eradication may significantly diminish and help halt progression of gastric mucosal inflammation and delay the development of IM and atrophy gastritis. Hp eradication is helpful for reducing the risk for gastric cancer, especially in the early stage of Hp infection.

语种: 英语
WOS记录号: WOS:000335936700012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57315
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: Peking Univ, Dept Gastroenterol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Zhou Liya,Lin Sanren,Ding Shigang,et al. Relationship of Helicobacter pylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study[J]. CHINESE MEDICAL JOURNAL,2014,127(8):1454-1458.
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