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Relationship of Helicobacter pylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study
Zhou Liya; Lin Sanren; Ding Shigang; Huang Xuebiao; Jin Zhu; Cui Rongli; Meng Lingmei; Li Yuan; Zhang Li; Guo Changji; Xue Yan; Yan Xiu′ e(1); Zhang Jing
关键词Helicobacter Pylori Gastric Cancer Atrophic Gastritis Intestinal Metaplasia
刊名CHINESE MEDICAL JOURNAL
2014-04-20
DOI10.3760/cma.j.issn.0366-6999.20132494
127期:8页:1454-1458
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]INTESTINAL METAPLASIA ; ATROPHIC GASTRITIS ; INFECTION ; RISK ; TRIAL ; CURE
英文摘要

Background Helicobacter pylori (Hp) is a common and potentially curable cause of gastric mucosa lesion. This study investigated the relationship of Hp infection with histological changes in gastric mucosa and gastric cancer in Hp-positive patients compared with Hp-eradication patients followed up for ten years.

Methods From an initial group of 1 006 adults, 552 Hp-positive subjects were randomly assigned to a treatment group (T; n=276) or a placebo group (P; n=276). In the randomized, double-blind, placebo-controlled, parallel trial, T group subjects received oral doses of omeprazole, amoxicillin and clarithromycin for 1 week; those in the P group received a placebo. One month after treatment ended, a C-13 urea breath test was performed, and Hp was undetectable in 88.89% of the T group. All subjects were followed at 1, 5, 8, and 10 years after treatment, with endoscopy and biopsies for histological examination.

Results Gastric mucosa inflammation was significantly milder in the T group than that in the P group one year after Hp eradication and this persisted for 10 years. Glandular atrophy and intestinal metaplasia (IM) had deteriorated in both groups during ten years. However, the increased score of glandular atrophy at both the gastric antrum and corpus, and IM only at the gastric antrum, in the P group was more obvious than that in the T group. During the 10 years, 9 patients were diagnosed with gastric cancer (2 in the T group; 7 in the P group; P=0.176). When mucosal atrophy was absent at the gastric antrum and corpus When entering the study, the incidence of gastric cancer in the P group (n=6) was much higher than that in the T group (n=0, P=0.013).

Conclusions Hp eradication may significantly diminish and help halt progression of gastric mucosal inflammation and delay the development of IM and atrophy gastritis. Hp eradication is helpful for reducing the risk for gastric cancer, especially in the early stage of Hp infection.

语种英语
WOS记录号WOS:000335936700012
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57315
专题北京大学第三临床医学院_消化科
北京大学第三临床医学院_肾内科
作者单位Peking Univ, Dept Gastroenterol, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhou Liya,Lin Sanren,Ding Shigang,et al. Relationship of Helicobacter pylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study[J]. CHINESE MEDICAL JOURNAL,2014,127(8):1454-1458.
APA Zhou Liya.,Lin Sanren.,Ding Shigang.,Huang Xuebiao.,Jin Zhu.,...&Zhang Jing.(2014).Relationship of Helicobacter pylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study.CHINESE MEDICAL JOURNAL,127(8),1454-1458.
MLA Zhou Liya,et al."Relationship of Helicobacter pylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study".CHINESE MEDICAL JOURNAL 127.8(2014):1454-1458.
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