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学科主题口腔医学
Detection of Eight Periodontal Microorganisms and Distribution of Porphyromonas gingivalis fimA Genotypes in Chinese Patients With Aggressive Periodontitis
Feng, Xianghui; Zhang, Li; Xu, Li; Meng, Huanxin; Lu, Ruifang; Chen, Zhibin; Shi, Dong; Wang, Xiane
关键词Aggressive Periodontitis Microbiology Saliva
刊名JOURNAL OF PERIODONTOLOGY
2014
DOI10.1902/jop.2013.120677
85期:1页:150-159
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]EARLY-ONSET PERIODONTITIS ; POLYMERASE-CHAIN-REACTION ; AGGREGATIBACTER-ACTINOMYCETEMCOMITANS ; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS ; SUBGINGIVAL MICROBIOTA ; HEALTH-STATUS ; PREVALENCE ; BACTERIA ; POPULATION ; PATHOGENS
英文摘要

Background: The microbiologic feature of aggressive periodontitis (AgP) in Chinese patients has not yet been determined. This study aims to investigate the prevalence of eight periodontal microorganisms and the distribution of the Porphyromonas gingivalis fimA genotype in a cohort of Chinese patients with AgP.

Methods: Saliva and pooled subgingival plaque samples were collected from 81 patients with AgP (25 with incisor-first molar type and 56 with generalized type [GAgP]) and 34 periodontally healthy controls. Eight periodontal microorganisms, including Aggregatibacter actinomycetemcomitans, P. gingivalis, Tannerella forsythia, Treponema denticola, Campylobacter rectus, Prevotella intermedia, Prevotella nigrescens, and Fusobacterium nucleatum were detected in these samples by the polymerase chain reaction (PCR). In addition, the distribution of fimA genotypes was assessed in P. gingivalis-positive individuals by PCR.

Results: The prevalence of P. gingivalis, T. forsythia, T. denticola, C. rectus, P. intermedia, F. nucleatum, and A. actinomycetemcomitans in patients with AgP was significantly higher than that in healthy controls. The prevalence of A. actinomycetemcomitans in patients with GAgP was relatively low (30.4%) compared with other pathogens. Results of logistic regression analysis showed that younger patients were more likely to harbor A. actinomycetemcomitans (odds ratio = 2.85). Type II was the most prevalent fimA genotype of P. gingivalis in patients with AgP.

Conclusions: P. gingivalis, T. forsythia, T. denticola, C. rectus, P. intermedia, and F. nucleatum were the predominant periodontal pathogens of patients with GAgP in China. Type II of fimA was the most prevalent genotype of P. gingivalis in patients with AgP. The prevalence of A. actinomycetemcomitans in patients with GAgP was relatively low.

语种英语
所属项目编号30471882 ; 30973319 ; 81100748 ; 81271149
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000331139400020
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57321
专题北京大学口腔医学院_牙周科
作者单位Peking Univ, Sch & Hosp Stomatol, Dept Periodontol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Feng, Xianghui,Zhang, Li,Xu, Li,et al. Detection of Eight Periodontal Microorganisms and Distribution of Porphyromonas gingivalis fimA Genotypes in Chinese Patients With Aggressive Periodontitis[J]. JOURNAL OF PERIODONTOLOGY,2014,85(1):150-159.
APA Feng, Xianghui.,Zhang, Li.,Xu, Li.,Meng, Huanxin.,Lu, Ruifang.,...&Wang, Xiane.(2014).Detection of Eight Periodontal Microorganisms and Distribution of Porphyromonas gingivalis fimA Genotypes in Chinese Patients With Aggressive Periodontitis.JOURNAL OF PERIODONTOLOGY,85(1),150-159.
MLA Feng, Xianghui,et al."Detection of Eight Periodontal Microorganisms and Distribution of Porphyromonas gingivalis fimA Genotypes in Chinese Patients With Aggressive Periodontitis".JOURNAL OF PERIODONTOLOGY 85.1(2014):150-159.
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