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IR@PKUHSC  > 北京大学口腔医学院  > 牙周科  > 期刊论文
学科主题: 口腔医学
题名:
Detection of Eight Periodontal Microorganisms and Distribution of Porphyromonas gingivalis fimA Genotypes in Chinese Patients With Aggressive Periodontitis
作者: Feng, Xianghui; Zhang, Li; Xu, Li; Meng, Huanxin; Lu, Ruifang; Chen, Zhibin; Shi, Dong; Wang, Xiane
关键词: Aggressive periodontitis ; microbiology ; saliva
刊名: JOURNAL OF PERIODONTOLOGY
发表日期: 2014
DOI: 10.1902/jop.2013.120677
卷: 85, 期:1, 页:150-159
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: EARLY-ONSET PERIODONTITIS ; POLYMERASE-CHAIN-REACTION ; AGGREGATIBACTER-ACTINOMYCETEMCOMITANS ; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS ; SUBGINGIVAL MICROBIOTA ; HEALTH-STATUS ; PREVALENCE ; BACTERIA ; POPULATION ; PATHOGENS
英文摘要:

Background: The microbiologic feature of aggressive periodontitis (AgP) in Chinese patients has not yet been determined. This study aims to investigate the prevalence of eight periodontal microorganisms and the distribution of the Porphyromonas gingivalis fimA genotype in a cohort of Chinese patients with AgP.

Methods: Saliva and pooled subgingival plaque samples were collected from 81 patients with AgP (25 with incisor-first molar type and 56 with generalized type [GAgP]) and 34 periodontally healthy controls. Eight periodontal microorganisms, including Aggregatibacter actinomycetemcomitans, P. gingivalis, Tannerella forsythia, Treponema denticola, Campylobacter rectus, Prevotella intermedia, Prevotella nigrescens, and Fusobacterium nucleatum were detected in these samples by the polymerase chain reaction (PCR). In addition, the distribution of fimA genotypes was assessed in P. gingivalis-positive individuals by PCR.

Results: The prevalence of P. gingivalis, T. forsythia, T. denticola, C. rectus, P. intermedia, F. nucleatum, and A. actinomycetemcomitans in patients with AgP was significantly higher than that in healthy controls. The prevalence of A. actinomycetemcomitans in patients with GAgP was relatively low (30.4%) compared with other pathogens. Results of logistic regression analysis showed that younger patients were more likely to harbor A. actinomycetemcomitans (odds ratio = 2.85). Type II was the most prevalent fimA genotype of P. gingivalis in patients with AgP.

Conclusions: P. gingivalis, T. forsythia, T. denticola, C. rectus, P. intermedia, and F. nucleatum were the predominant periodontal pathogens of patients with GAgP in China. Type II of fimA was the most prevalent genotype of P. gingivalis in patients with AgP. The prevalence of A. actinomycetemcomitans in patients with GAgP was relatively low.

语种: 英语
所属项目编号: 30471882 ; 30973319 ; 81100748 ; 81271149
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000331139400020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57321
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: Peking Univ, Sch & Hosp Stomatol, Dept Periodontol, Beijing 100081, Peoples R China

Recommended Citation:
Feng, Xianghui,Zhang, Li,Xu, Li,et al. Detection of Eight Periodontal Microorganisms and Distribution of Porphyromonas gingivalis fimA Genotypes in Chinese Patients With Aggressive Periodontitis[J]. JOURNAL OF PERIODONTOLOGY,2014,85(1):150-159.
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