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学科主题: 临床医学
题名:
The levels of bone turnover markers in Chinese postmenopausal women: Peking Vertebral Fracture study
作者: Zhao, Jing1; Xia, Weibo1; Nie, Min1; Zheng, Xin2; Wang, Qiuping3; Wang, Xiran4; Wang, Wenbo5; Ning, Zhiwei6; Huang, Wei7; Jiang, Yan1; Li, Mei1; Wang, Ou1; Xing, Xiaoping1; Sun, Yue1; Luo, Lianmei1; He, Shuli1; Yu, Wei8; Lin, Qiang8; Pei, Yu9; Zhang, Fan3; Han, Youxia7; Tong, Yanmin2; Che, Ying5; Shen, Ruixin10; Hu, Yingying1; Zhou, Xueying1; Xu, Ling11
关键词: Bone mineral density ; C-terminal telopeptide of type I collagen ; Fracture ; N-aminoterminal propeptide of type I collagen ; Vertebral fracture ; 25-Hydroxyvitamin D
刊名: MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
发表日期: 2011-11-01
DOI: 10.1097/gme.0b013e31821d7ff7
卷: 18, 期:11, 页:1237-1243
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: VITAMIN-D STATUS ; ELDERLY-WOMEN ; MINERAL DENSITY ; BIOCHEMICAL MARKERS ; D SUPPLEMENTATION ; HIP FRACTURE ; I COLLAGEN ; METABOLISM ; PREDICTION ; OSTEOPOROSIS
英文摘要:

Objective: The aim of this study was to evaluate serum N-aminoterminal propeptide of type I collagen (P1NP), C-terminal telopeptide of type I collagen (beta-CTX), and vitamin D status in healthy Chinese postmenopausal women. The study was also designed to investigate their possible relationships with osteoporosis phenotypes.

Methods: A community-based population of 1,724 postmenopausal women in Beijing was randomly selected. Serum bone turnover markers and 25-hydroxyvitamin D [25(OH) D] were tested by an automated Roche electro-chemiluminescence system. Dual-energy x-ray absorptiometry was used to measure bone mineral density (BMD).

Results: The mean (SD) values of serum beta-CTX and P1NP were 0.439 (0.210) and 56.7 (27.9) ng/mL, respectively. The 25(OH) D level of postmenopausal women in Beijing was remarkably low (13.2 +/- 5.4 ng/mL). Serum beta-CTX and P1NP levels were negatively correlated with BMDs of lumbar spine, femoral neck, and total hip (all P < 0.01). The cubic regression model better fitted the relationships of BMD and bone turnover markers. Serum beta-CTX levels were significantly higher in women with sustained osteoporotic fracture or vertebral fracture (P = 0.006 and 0.012, respectively). No association between P1NP and fracture or vertebral fracture was detected. The same situation applied to 25(OH) D. 25(OH) D was negatively correlated with beta-CTX and P1NP (r = -0.073 and -0.088, P = 0.002 and <0.001, respectively).

Conclusions: Serum beta-CTX and P1NP levels were negatively correlated with BMD. beta-CTX was significantly higher in postmenopausal women with sustained fracture or vertebral fracture. Vitamin D deficiency was highly prevalent in postmenopausal women in Beijing.

语种: 英语
所属项目编号: 2005DIB1J085 ; 2006BAI02B03 ; 81070687
项目资助者: National Special Research Foundation for the Commonweal of Society ; National Science and Technology Pillar Program ; National Natural Science Foundation of China
WOS记录号: WOS:000296605500016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57332
Appears in Collections:北京大学首钢医院_内分泌科_期刊论文

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作者单位: 1.China Rehabil Res Ctr, Dept Endocrinol, Beijing, Peoples R China
2.Beijing Liangxiang Hosp, Dept Endocrinol, Beijing, Peoples R China
3.Beijing Haidian Hosp, Dept Endocrinol, Beijing, Peoples R China
4.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Minist Hlth, Dept Endocrinol,Key Lab Endocrinol, Beijing 100730, Peoples R China
5.Gen Hosp Second Artillery Force, Dept Cadre Unit, Beijing, Peoples R China
6.Peking Univ, Shougang Hosp, Dept Endocrinol, Beijing 100871, Peoples R China
7.Capital Univ Med Sci, Beijing Chaoyang Hosp, Dept Endocrinol, Beijing, Peoples R China
8.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, Beijing 100730, Peoples R China
9.Gen Hosp, Chinese Peoples Liberat Army, Dept Geriatr Endocrinol, Beijing, Peoples R China
10.Capital Univ Med Sci, Beijing Chaoyang Hosp, Dept Orthoped, Beijing, Peoples R China
11.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, Beijing 100730, Peoples R China

Recommended Citation:
Zhao, Jing,Xia, Weibo,Nie, Min,et al. The levels of bone turnover markers in Chinese postmenopausal women: Peking Vertebral Fracture study[J]. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY,2011,18(11):1237-1243.
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