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Reversal Effect of ST6GAL 1 on Multidrug Resistance in Human Leukemia by Regulating the PI3K/Akt Pathway and the Expression of P-gp and MRP1
Ma, Hongye1; Cheng, Lei2; Hao, Keji3; Li, Yanping1; Song, Xiaobo4; Zhou, Huimin5; Jia, Li1
刊名PLOS ONE
2014-01-16
DOI10.1371/journal.pone.0085113
9期:1
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]NF-KAPPA-B ; BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASES ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; COLON-CARCINOMA CELLS ; COLORECTAL-CANCER ; GASTRIC-CANCER ; IN-VITRO ; ACTIVATION ; GLYCOPROTEIN ; INHIBITOR
英文摘要

beta-galactoside alpha 2, 6-sialyltransferse gene (ST6GAL) family has two members, which encode corresponding enzymes ST6Gal I and ST6Gal II. The present atudy was to investigate whether and how ST6GAL family involved in multidrug resistance (MDR) in human leukemia cell lines and bone marrow mononuclear cells (BMMC) of leukemia patients. Real-time PCR showed a high expression level of ST6GAL1 gene in both MDR cells and BMMCs (*P<0.05). Alternation of ST6GAL1 levels had a significant impact on drug-resistant phenotype changing of K562 and K562/ADR cells both in vitro and in vivo. However, no significant changes were observed of ST6GAL2 gene. Further data revealed that manipulation of ST6GAL1 modulated the activity of phosphoinositide 3 kinase (PI3K)/Akt signaling and consequently regulated the expression of P-glycoprotein (P-gp, *P<0.05) and multidrug resistance related protein 1 (MRP1, *P<0.05), which are both known to be associated with MDR. Therefore we postulate that ST6GAL1 is responsible for the development of MDR in human leukemia cells probably through medicating the activity of PI3K/Akt signaling and the expression of P-gp and MRP1.

语种英语
WOS记录号WOS:000330236000008
项目编号2012CB822100 ; 81071415 ; 81271910
资助机构National Key Basic Research and Development Program (973 program) of China ; National Natural Science Foundation of China
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57334
专题北京大学第二临床医学院_核医学科
作者单位1.Med Univ, Coll Lab Med, Dalian, Liaoning Provin, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 1, Dept Laparoscop Surg, Dalian, Liaoning Provin, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Nucl Med, Beijing 100871, Peoples R China
4.Univ Tromso, Fac Hlth Sci, Dept Med Biol, Tromso, Norway
5.Dalian Med Univ, Dept Microbiol, Dalian, Liaoning Provin, Peoples R China
推荐引用方式
GB/T 7714
Ma, Hongye,Cheng, Lei,Hao, Keji,et al. Reversal Effect of ST6GAL 1 on Multidrug Resistance in Human Leukemia by Regulating the PI3K/Akt Pathway and the Expression of P-gp and MRP1[J]. PLOS ONE,2014,9(1).
APA Ma, Hongye.,Cheng, Lei.,Hao, Keji.,Li, Yanping.,Song, Xiaobo.,...&Jia, Li.(2014).Reversal Effect of ST6GAL 1 on Multidrug Resistance in Human Leukemia by Regulating the PI3K/Akt Pathway and the Expression of P-gp and MRP1.PLOS ONE,9(1).
MLA Ma, Hongye,et al."Reversal Effect of ST6GAL 1 on Multidrug Resistance in Human Leukemia by Regulating the PI3K/Akt Pathway and the Expression of P-gp and MRP1".PLOS ONE 9.1(2014).
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