IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Influence of acetylsalicylate on plasma lysophosphatidic acid level in patients with ischemic cerebral vascular diseases
Li, Zhen-Guang1; Yu, Zhan-Cai1; Wang, Dao-Zhen1; Ju, Wei-Ping1; Zhan, Xia1; Wu, Qi-Zhuan2; Wu, Xi-Juan1; Cong, Hai-Ming1; Man, Hong-Hao1
关键词Lysophosphatidic Acid Ischemic Stroke Platelet Activation
刊名NEUROLOGICAL RESEARCH
2008-05-01
DOI10.1179/174313208X300369
30期:4页:366-369
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]SPHINGOSINE 1-PHOSPHATE ; MYOCARDIAL-INFARCTION ; STROKE ; PREVENTION ; PLATELETS ; ASPIRIN ; THERAPY ; IDENTIFICATION ; MECHANISMS ; RECEPTORS
英文摘要

Background and purpose: Lysophosphatidic acid (LPA) is released from activated platelets. Acetylsalicylate (aspirin) is the most commonly used antiplatelet drug. The purpose of this study is to observe whether treatment with acetylsalicylate decreases the LPA level in patients with ischemic cerebrovascular diseases.

Methods: We performed a study examining LPA level in fresh plasma in cases and controls enrolled in the LPA and Stroke Prevention Study. Level of LPA was assayed by measuring its inorganic phosphorus after separation by chromatography.

Results: An elevated LPA level was seen in cases (n=254) with ischemic cerebrovascular disease (3.11 +/- 1.55 mmol/l) compared with 136 healthy controls (1.77 +/- 1.04 mmol/l) (p<0.001). Administration of aspirin (100 mg q.d.) for 1 month significantly lowered LPA level in patients (n=142) (2.41 +/- 1.03 mmol/l) compared with that before taking acetylsalicylate (4.06 +/- 1.03 mmol/l) (p<0.001). However, the LPA level in patients (n=36) who stopped acetylsalicylate after taking it for 1 month was re-elevated. Before and after taking acetylsalicylate for 1 month, their LPA levels were 4.23 +/- 1.15 and 1.93 +/- 0.85 mmol/l, respectively. After 1 month withdrawal, level was 3.90 +/- 1.09 mmol/l (p<0.001 compared that before taking acetylsalicylate).

Conclusion: Our findings support a close association between increased plasma LPA level and platelet activation. Acetylsalicylate could decrease plasma LPA levels, which may be used as a mechanism for acetylsalicylate in the prevention of ischemic stroke.

语种英语
WOS记录号WOS:000256837800009
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57336
专题北京大学第一临床医学院
作者单位1.Wendeng Cent Hosp, Weifang Med Coll, Dept Neurol, Weifang, Peoples R China
2.Beijing Univ, Hosp 1, Neurochem Lab, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Zhen-Guang,Yu, Zhan-Cai,Wang, Dao-Zhen,et al. Influence of acetylsalicylate on plasma lysophosphatidic acid level in patients with ischemic cerebral vascular diseases[J]. NEUROLOGICAL RESEARCH,2008,30(4):366-369.
APA Li, Zhen-Guang.,Yu, Zhan-Cai.,Wang, Dao-Zhen.,Ju, Wei-Ping.,Zhan, Xia.,...&Man, Hong-Hao.(2008).Influence of acetylsalicylate on plasma lysophosphatidic acid level in patients with ischemic cerebral vascular diseases.NEUROLOGICAL RESEARCH,30(4),366-369.
MLA Li, Zhen-Guang,et al."Influence of acetylsalicylate on plasma lysophosphatidic acid level in patients with ischemic cerebral vascular diseases".NEUROLOGICAL RESEARCH 30.4(2008):366-369.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Zhen-Guang]的文章
[Yu, Zhan-Cai]的文章
[Wang, Dao-Zhen]的文章
百度学术
百度学术中相似的文章
[Li, Zhen-Guang]的文章
[Yu, Zhan-Cai]的文章
[Wang, Dao-Zhen]的文章
必应学术
必应学术中相似的文章
[Li, Zhen-Guang]的文章
[Yu, Zhan-Cai]的文章
[Wang, Dao-Zhen]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。