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学科主题: 临床医学
题名:
Influence of acetylsalicylate on plasma lysophosphatidic acid level in patients with ischemic cerebral vascular diseases
作者: Li, Zhen-Guang1; Yu, Zhan-Cai1; Wang, Dao-Zhen1; Ju, Wei-Ping1; Zhan, Xia1; Wu, Qi-Zhuan2; Wu, Xi-Juan1; Cong, Hai-Ming1; Man, Hong-Hao1
关键词: lysophosphatidic acid ; ischemic stroke ; platelet activation
刊名: NEUROLOGICAL RESEARCH
发表日期: 2008-05-01
DOI: 10.1179/174313208X300369
卷: 30, 期:4, 页:366-369
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: SPHINGOSINE 1-PHOSPHATE ; MYOCARDIAL-INFARCTION ; STROKE ; PREVENTION ; PLATELETS ; ASPIRIN ; THERAPY ; IDENTIFICATION ; MECHANISMS ; RECEPTORS
英文摘要:

Background and purpose: Lysophosphatidic acid (LPA) is released from activated platelets. Acetylsalicylate (aspirin) is the most commonly used antiplatelet drug. The purpose of this study is to observe whether treatment with acetylsalicylate decreases the LPA level in patients with ischemic cerebrovascular diseases.

Methods: We performed a study examining LPA level in fresh plasma in cases and controls enrolled in the LPA and Stroke Prevention Study. Level of LPA was assayed by measuring its inorganic phosphorus after separation by chromatography.

Results: An elevated LPA level was seen in cases (n=254) with ischemic cerebrovascular disease (3.11 +/- 1.55 mmol/l) compared with 136 healthy controls (1.77 +/- 1.04 mmol/l) (p<0.001). Administration of aspirin (100 mg q.d.) for 1 month significantly lowered LPA level in patients (n=142) (2.41 +/- 1.03 mmol/l) compared with that before taking acetylsalicylate (4.06 +/- 1.03 mmol/l) (p<0.001). However, the LPA level in patients (n=36) who stopped acetylsalicylate after taking it for 1 month was re-elevated. Before and after taking acetylsalicylate for 1 month, their LPA levels were 4.23 +/- 1.15 and 1.93 +/- 0.85 mmol/l, respectively. After 1 month withdrawal, level was 3.90 +/- 1.09 mmol/l (p<0.001 compared that before taking acetylsalicylate).

Conclusion: Our findings support a close association between increased plasma LPA level and platelet activation. Acetylsalicylate could decrease plasma LPA levels, which may be used as a mechanism for acetylsalicylate in the prevention of ischemic stroke.

语种: 英语
WOS记录号: WOS:000256837800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57336
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Wendeng Cent Hosp, Weifang Med Coll, Dept Neurol, Weifang, Peoples R China
2.Beijing Univ, Hosp 1, Neurochem Lab, Beijing 100871, Peoples R China

Recommended Citation:
Li, Zhen-Guang,Yu, Zhan-Cai,Wang, Dao-Zhen,et al. Influence of acetylsalicylate on plasma lysophosphatidic acid level in patients with ischemic cerebral vascular diseases[J]. NEUROLOGICAL RESEARCH,2008,30(4):366-369.
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