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Aminoglycoside mimetics as small-molecule drugs targeting RNA
Ye, XS; Zhang, LH
刊名CURRENT MEDICINAL CHEMISTRY
2002-05-01
9期:9页:929-939
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]30S RIBOSOMAL-SUBUNIT ; ANGSTROM RESOLUTION ; A-SITE ; PROTECTED GUANIDINES ; RECOGNIZE RNA ; ANTIBIOTICS ; BINDING ; RESISTANCE ; DESIGN ; MOTIF
英文摘要

The potential of RNA as a new drug target has recently come to the fore, with the recognition that RNA molecules can adopt complex three-dimensional structures that, as with proteins, enable the design of specific ligands. Another reason for the present interest comes from the fact that many pathogenic agents, such as retroviruses, encode their genetic information in RNA strands. Unfortunately, the high toxicity and rapid emergence of high-level resistance have severely limited the usefulness of naturally occurring aminoglycoside antibiotics. To tackle these problems, it is an important concern to design new synthetic compounds with smaller, simpler structures which possess higher RNA binding affinity, better selectivity, better antibiotic activity, and stronger resistance against the aminoglycoside-modifying enzymes compared to their parent structures. Here, we will attempt a survey of current efforts to develop aminoglycoside mimetics or derivatives that target RNA. The latest advances in this field including rational design, synthetic strategy, and structure activity relationships are reviewed.

语种英语
WOS记录号WOS:000175310600003
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57340
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Natural & Biomimet Drugs, Beijing 100083, Peoples R China
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GB/T 7714
Ye, XS,Zhang, LH. Aminoglycoside mimetics as small-molecule drugs targeting RNA[J]. CURRENT MEDICINAL CHEMISTRY,2002,9(9):929-939.
APA Ye, XS,&Zhang, LH.(2002).Aminoglycoside mimetics as small-molecule drugs targeting RNA.CURRENT MEDICINAL CHEMISTRY,9(9),929-939.
MLA Ye, XS,et al."Aminoglycoside mimetics as small-molecule drugs targeting RNA".CURRENT MEDICINAL CHEMISTRY 9.9(2002):929-939.
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