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学科主题: 药学
题名:
Aminoglycoside mimetics as small-molecule drugs targeting RNA
作者: Ye, XS; Zhang, LH
刊名: CURRENT MEDICINAL CHEMISTRY
发表日期: 2002-05-01
卷: 9, 期:9, 页:929-939
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: 30S RIBOSOMAL-SUBUNIT ; ANGSTROM RESOLUTION ; A-SITE ; PROTECTED GUANIDINES ; RECOGNIZE RNA ; ANTIBIOTICS ; BINDING ; RESISTANCE ; DESIGN ; MOTIF
英文摘要:

The potential of RNA as a new drug target has recently come to the fore, with the recognition that RNA molecules can adopt complex three-dimensional structures that, as with proteins, enable the design of specific ligands. Another reason for the present interest comes from the fact that many pathogenic agents, such as retroviruses, encode their genetic information in RNA strands. Unfortunately, the high toxicity and rapid emergence of high-level resistance have severely limited the usefulness of naturally occurring aminoglycoside antibiotics. To tackle these problems, it is an important concern to design new synthetic compounds with smaller, simpler structures which possess higher RNA binding affinity, better selectivity, better antibiotic activity, and stronger resistance against the aminoglycoside-modifying enzymes compared to their parent structures. Here, we will attempt a survey of current efforts to develop aminoglycoside mimetics or derivatives that target RNA. The latest advances in this field including rational design, synthetic strategy, and structure activity relationships are reviewed.

语种: 英语
WOS记录号: WOS:000175310600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57340
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Natural & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Ye, XS,Zhang, LH. Aminoglycoside mimetics as small-molecule drugs targeting RNA[J]. CURRENT MEDICINAL CHEMISTRY,2002,9(9):929-939.
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