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学科主题: 临床医学
题名:
The Lyapunov exponent of the EEG after administration of topiramate
作者: Li, JC; Wang, W; Wang, YH; Wu, X
关键词: electroencephalography ; epilepsy ; nonlinear analysis ; quantitative pharmacoelectroencephalography ; topiramate
刊名: CLINICAL EEG AND NEUROSCIENCE
发表日期: 2005-07-01
卷: 36, 期:3, 页:202-206
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences ; Neuroimaging
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: EPILEPTIC PATIENTS ; QUANTITATIVE EEG ; FOCAL EPILEPSY ; PHARMACO-EEG ; VALPROATE ; LAMOTRIGINE ; VIGABATRIN ; GABAPENTIN ; VOLUNTEERS ; COMPLEXITY
英文摘要:

The objective of our study was to investigate the effect of topiramate (TPM) on the Lyapunov exponent of EEG by means of quantitative pharmacoelectroencephalography (QPEEG) and nonlinear analysis methods. One dose of TPM was administrated to epileptics and healthy adults. EEG samples were obtained prior to and at regular intervals (at 0.5, 1, 2, 4, 6, 8, 12, 24 hours) within the 24 hours following the administration of TPM. EEG activity was processed with nonlinear analysis methods. The Lyapunov exponent of the scalp areas was calculated through 60 s epochs without artifacts after each recording. The statistical difference between baseline predrug assessment and each postdrug control was calculated by computing the paired t test. Results showed that the Lyapunov exponent increased first, then decreased, then increased finally. We conclude that TPM can change the complexity of EEG.

语种: 英语
WOS记录号: WOS:000230850100010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57343
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China

Recommended Citation:
Li, JC,Wang, W,Wang, YH,et al. The Lyapunov exponent of the EEG after administration of topiramate[J]. CLINICAL EEG AND NEUROSCIENCE,2005,36(3):202-206.
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