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学科主题临床医学
The Lyapunov exponent of the EEG after administration of topiramate
Li, JC; Wang, W; Wang, YH; Wu, X
关键词Electroencephalography Epilepsy Nonlinear Analysis Quantitative Pharmacoelectroencephalography Topiramate
刊名CLINICAL EEG AND NEUROSCIENCE
2005-07-01
36期:3页:202-206
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences ; Neuroimaging
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]EPILEPTIC PATIENTS ; QUANTITATIVE EEG ; FOCAL EPILEPSY ; PHARMACO-EEG ; VALPROATE ; LAMOTRIGINE ; VIGABATRIN ; GABAPENTIN ; VOLUNTEERS ; COMPLEXITY
英文摘要

The objective of our study was to investigate the effect of topiramate (TPM) on the Lyapunov exponent of EEG by means of quantitative pharmacoelectroencephalography (QPEEG) and nonlinear analysis methods. One dose of TPM was administrated to epileptics and healthy adults. EEG samples were obtained prior to and at regular intervals (at 0.5, 1, 2, 4, 6, 8, 12, 24 hours) within the 24 hours following the administration of TPM. EEG activity was processed with nonlinear analysis methods. The Lyapunov exponent of the scalp areas was calculated through 60 s epochs without artifacts after each recording. The statistical difference between baseline predrug assessment and each postdrug control was calculated by computing the paired t test. Results showed that the Lyapunov exponent increased first, then decreased, then increased finally. We conclude that TPM can change the complexity of EEG.

语种英语
WOS记录号WOS:000230850100010
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57343
专题北京大学第一临床医学院_神经内科
作者单位Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Li, JC,Wang, W,Wang, YH,et al. The Lyapunov exponent of the EEG after administration of topiramate[J]. CLINICAL EEG AND NEUROSCIENCE,2005,36(3):202-206.
APA Li, JC,Wang, W,Wang, YH,&Wu, X.(2005).The Lyapunov exponent of the EEG after administration of topiramate.CLINICAL EEG AND NEUROSCIENCE,36(3),202-206.
MLA Li, JC,et al."The Lyapunov exponent of the EEG after administration of topiramate".CLINICAL EEG AND NEUROSCIENCE 36.3(2005):202-206.
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