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The use of a tumor metastasis targeting peptide to deliver doxorubicin-containing liposomes to highly metastatic cancer
Wang, Zhaohui1,2; Yu, Yang1,2; Dai, Wenbing2; Lu, Jingkai2; Cui, Jingrong3; Wu, Hounan4; Yuan, Lan4; Zhang, Hua2; Wang, Xueqing2; Wang, Jiancheng2; Zhang, Xuan2; Zhan, Qiang1,2
关键词Highly Metastatic Tumor Targeting Nanomedicine Liposomes Delivery
刊名BIOMATERIALS
2012-11-01
DOI10.1016/j.biomaterials.2012.08.031
33期:33页:8451-8460
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
资助者National Natural Science Foundation of China ; National Research Fund for Fundamental Key Project ; National Natural Science Foundation of China ; National Research Fund for Fundamental Key Project
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]BREAST-CANCER ; MOLECULAR-MECHANISMS ; MULTIDRUG-RESISTANCE ; LIPID NANOPARTICLES ; LOADED LIPOSOMES ; DRUG-RESISTANT ; THERAPY ; MICELLES ; TISSUE ; CELLS
英文摘要

Tumor metastasis is responsible for 90% of cancer-associated deaths and highly metastatic cancers are more prone to form metastasis foci and acquire the drug resistance. Here, a nanocarrier system (TMT-LS) has been constructed by modification of stealth liposomes with a metastatic cancer specific peptide, using the unmodified stealth liposomes (LS) as the control. The active targeted nanocarriers presented satisfactory particle size (about 100 nm) and drug release characteristics in vitro. Highly metastatic cancer cells (MDA-MB-435S and MDA-MB-231) and non-metastatic cancer cells (MCF-7) were applied as tumor cell models. The highly metastatic cancer cells were found to endocytose more TMT-LS in a faster way than TS, through a receptor-mediated pathway proved by specific receptor inhibition. Co-localization technique indicated the integrity of nanocarriers in cytoplasm. The significant targeting of TMT-LS to highly metastatic tumors was demonstrated in vivo and ex vivo in an orthotopic model as well as in a double tumor-bearing animal model with both metastatic and non-metastatic tumors in the same mouse. Importantly, the active targeted drug delivery system was found to penetrate deeper into tumor mass and have a longer retention within the malignant tissue. Further, TMT-LS greatly facilitated the efficacy of doxorubicin loaded in terms of inhibiting xenograft tumor growth and inducing cancer cell apoptosis, with only minor side effects. Together, the specific nanocarriers hold great potential in the development of nanomedicine for diagnosis and therapy of metastatic tumor. (C) 2012 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号81130059 ; 2009CB930300
资助者National Natural Science Foundation of China ; National Research Fund for Fundamental Key Project ; National Natural Science Foundation of China ; National Research Fund for Fundamental Key Project
WOS记录号WOS:000310401000025
引用统计
被引频次:65[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57351
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Peking Univ, Dept Pharmacol, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
4.Peking Univ, Med & Healthy Analyt Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Zhaohui,Yu, Yang,Dai, Wenbing,et al. The use of a tumor metastasis targeting peptide to deliver doxorubicin-containing liposomes to highly metastatic cancer[J]. BIOMATERIALS,2012,33(33):8451-8460.
APA Wang, Zhaohui.,Yu, Yang.,Dai, Wenbing.,Lu, Jingkai.,Cui, Jingrong.,...&Zhan, Qiang.(2012).The use of a tumor metastasis targeting peptide to deliver doxorubicin-containing liposomes to highly metastatic cancer.BIOMATERIALS,33(33),8451-8460.
MLA Wang, Zhaohui,et al."The use of a tumor metastasis targeting peptide to deliver doxorubicin-containing liposomes to highly metastatic cancer".BIOMATERIALS 33.33(2012):8451-8460.
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