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学科主题: 临床医学
题名:
Intraoperative Detection of Thyroid Carcinoma by Fourier Transform Infrared Spectrometry
作者: Zhang, Xiaoqing; Xu, Yizhuang2; Zhang, Yuanfu2; Wang, Lixin; Hou, Chunsheng; Zhou, Xiaosi; Ling, Xiaofeng1; Xu, Zhi1
关键词: FTIR ; thyroid tumor ; canonical discriminant analysis
刊名: JOURNAL OF SURGICAL RESEARCH
发表日期: 2011-12-01
DOI: 10.1016/j.jss.2010.05.031
卷: 171, 期:2, 页:650-656
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: FINE-NEEDLE-ASPIRATION ; FROZEN-SECTION EXAMINATION ; CANCER ; MICROSPECTROSCOPY ; ACCURACY ; CYTOLOGY ; NODULES ; BIOPSY ; SPECTROSCOPY ; RECOGNITION
英文摘要:

Background. Fourier transform infrared ( FTIR) spectroscopy is a powerful tool for distinguishing cancerous tissue from normal one. Our aim in this study was to establish tissue discriminant analysis for thyroid malignancy and benign samples intraoperatively using FTIR spectroscopy.

Methods. Seventeen papillary thyroid cancer and 43 nodular goiter tissues were obtained and underwent FTIR spectroscopy scanning intraoperatively. Nine peak positions were identified and assigned. Peak position values and wave intensity ratios were measured in every single spectrum. Data of malignant and benign groups were compared and equations of canonical discriminant analysis were established.

Results. Peak positions of P1640, P1240, P1550, and peak intensity ratios of I3375/I1460, I1640/I1460, I1400/I1460, I1550/I1080, I1080/I1460, and I1640/I1550 of thyroid papillary carcinoma group are significantly different from nodular goiter group. The sensitivity, specificity, and accuracy rate of the discriminants are 83.3%, 95.2%, and 91.67%, respectively.

Conclusion. FTIR spectroscopy technique in combination with canonical discriminant analysis method can achieve fast and accurate discrimination for malignant and benign thyroid nodules during operation (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2007AA04Z313 ; 2072020
项目资助者: National 863 Plan of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000296957900056
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57355
Appears in Collections:北京大学第三临床医学院_普通外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, State Key Lab Rare Earth Mat Chem & Applicat, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Xiaoqing,Xu, Yizhuang,Zhang, Yuanfu,et al. Intraoperative Detection of Thyroid Carcinoma by Fourier Transform Infrared Spectrometry[J]. JOURNAL OF SURGICAL RESEARCH,2011,171(2):650-656.
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