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学科主题临床医学
Physiological Biomarkers of Acute Kidney Injury: A Conceptual Approach to Improving Outcomes
Okusa, Mark D.1,2; Jaber, Bertrand L.3; Doran, Peter4; Duranteau, Jacques5; Yang, Li6; Murray, Patrick T.7; Mehta, Ravindra L.8; Ince, Can9; ADQI 10 Workgrp; McCullough, PA; Kellum, JA; Mehta, RL; Murray, PT; Ronco, C
刊名ADQI CONSENSUS ON AKI BIOMARKERS AND CARDIORENAL SYNDROMES
2013
DOI10.1159/000349967
182页:65-81
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]ACUTE-RENAL-FAILURE ; CONTRAST-ENHANCED ULTRASOUND ; NEAR-INFRARED SPECTROSCOPY ; GLOMERULAR-FILTRATION-RATE ; CRITICALLY-ILL PATIENTS ; URINARY OXYGEN-TENSION ; ACUTE TUBULAR-NECROSIS ; BOLD-MRI ; TISSUE OXYGENATION ; RESISTIVE INDEX
英文摘要

The past 5-10 years have brought significant advances in the identification and validation of novel biochemical biomarkers in the prevention and treatment of acute kidney injury (AKI). These biochemical biomarkers remain research tools but we anticipate that soon they will be employed in clinical practice. A Consensus Conference held by the Acute Dialysis Quality Initiative (ADQI) recently reviewed the evidence, and identified gaps and a research agenda. Furthermore, at this meeting was the birth of an initiative to comprehensively identify new opportunities to characterize the physiological changes during the course of AKI based upon a conceptual framework for the detection and monitoring of renal ischemia-reperfusion injury. This framework includes a transition from monitoring physiological biomarkers of adequate renal perfusion, to pathophysiologic biomarkers of renal hypoperfusion, and finally biomarkers of kidney cell structural injury/damage. Techniques to measure physiological changes in AKI include several physiological variables that might be used in an interactive way to supplement clinical information and biochemical damage biomarkers in the diagnosis and management of AKI. This review summarizes the spectrum of physiological parameters and potential new physiological methods that enable identification of high-risk patients for AKI, facilitate early diagnosis, and differential diagnosis to guide therapeutic management and prognostication. Finally, we propose a research agenda for the next 5 years to facilitate the development and validation of physiological biomarkers in AKI. Copyright (C) 2013 S. Karger AG, Basel

语种英语
WOS记录号WOS:000321800100006
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57368
专题北京大学第一临床医学院_肾脏内科
作者单位1.Univ Virginia, Div Nephrol, Charlottesville, VA USA
2.Peking Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R China
3.Univ Coll Dublin, Dept Med, Dublin 2, Ireland
4.Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USA
5.Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med,Div Nephrol,Kidney & Dialysis Res Lab, Boston, MA 02111 USA
6.Univ Coll Dublin, UCD Sch Med & Med Sci, UCD Clin Res Ctr, Dublin 2, Ireland
7.Univ Paris 11, Hop Paris, Hop Bicetre, Dept Anesthesie Reanimat, Le Kremlin Bicetre, France
8.Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA
9.Erasmus MC Univ, Med Ctr, Dept Intens Care Adults, Rotterdam, Netherlands
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GB/T 7714
Okusa, Mark D.,Jaber, Bertrand L.,Doran, Peter,et al. Physiological Biomarkers of Acute Kidney Injury: A Conceptual Approach to Improving Outcomes[J]. ADQI CONSENSUS ON AKI BIOMARKERS AND CARDIORENAL SYNDROMES,2013,182:65-81.
APA Okusa, Mark D..,Jaber, Bertrand L..,Doran, Peter.,Duranteau, Jacques.,Yang, Li.,...&Ronco, C.(2013).Physiological Biomarkers of Acute Kidney Injury: A Conceptual Approach to Improving Outcomes.ADQI CONSENSUS ON AKI BIOMARKERS AND CARDIORENAL SYNDROMES,182,65-81.
MLA Okusa, Mark D.,et al."Physiological Biomarkers of Acute Kidney Injury: A Conceptual Approach to Improving Outcomes".ADQI CONSENSUS ON AKI BIOMARKERS AND CARDIORENAL SYNDROMES 182(2013):65-81.
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