IR@PKUHSC  > 北京大学深圳医院
学科主题临床医学
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, Junjie1; Li, Yingrui1; Cai, Zhiming2; Li, Shenghui1; Zhu, Jianfeng1; Zhang, Fan3; Liang, Suisha1; Zhang, Wenwei1; Guan, Yuanlin1; Shen, Dongqian1; Peng, Yangqing1; Zhang, Dongya1; Jie, Zhuye1; Wu, Wenxian1; Qin, Youwen1; Xue, Wenbin1; Li, Junhua1; Han, Lingchuan3; Lu, Donghui3; Wu, Peixian3; Dai, Yali3; Sun, Xiaojuan3; Li, Zesong2; Tang, Aifa2; Zhong, Shilong2; Li, Xiaoping4; Chen, Weineng1; Xu, Ran1; Wang, Mingbang1; Feng, Qiang1; Gong, Meihua1; Yu, Jing1; Zhang, Yanyan1; Zhang, Ming1; Hansen, Torben5; Sanchez, Gaston6,7; Raes, Jeroen8,9; Falony, Gwen8,9; Okuda, Shujiro8,9; Almeida, Mathieu10; LeChatelier, Emmanuelle10; Renault, Pierre10; Pons, Nicolas10; Batto, Jean-Michel10; Zhang, Zhaoxi1; Chen, Hua1; Yang, Ruifu1,11; Zheng, Weimou1; Li, Songgang1; Yang, Huanming1; Wang, Jian1; Ehrlich, S. Dusko10; Nielsen, Rasmus6,7; Pedersen, Oluf5,12,13,14,15; Kristiansen, Karsten1,16; Wang, Jun1,5,16
刊名NATURE
2012-10-04
DOI10.1038/nature11450
490期:7418页:55-60
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]OBESITY ; DIVERSITY ; BACTEREMIA ; FRAGMENTS ; INFECTION ; VARIANTS ; DISEASE ; STRESS ; MICE
英文摘要

Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To carry out analysis on gut microbial content in patients with type 2 diabetes, we developed a protocol for a metagenome-wide association study (MGWAS) and undertook a two-stage MGWAS based on deep shotgun sequencing of the gut microbial DNA from 345 Chinese individuals. We identified and validated approximately 60,000 type-2-diabetes-associated markers and established the concept of a metagenomic linkage group, enabling taxonomic species-level analyses. MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance. An analysis of 23 additional individuals demonstrated that these gut microbial markers might be useful for classifying type 2 diabetes.

语种英语
WOS记录号WOS:000309446800031
项目编号2012AA02A201 ; 30890032 ; 30725008 ; 30811130531 ; 31161130357 ; ZYC200903240080A ; BGI20100001 ; CXB201108250096A ; CXB201108250098A ; 2106-07-0021 ; 272-07-0196 ; HEALTH-F4-2007-201052
资助机构Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Shenzhen Municipal Government of China ; Danish Strategic Research Council ; Danish Natural Science Research Council ; Solexa project ; European Commission ; Novo Nordisk Foundation
引用统计
被引频次:1397[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57376
专题北京大学深圳医院
作者单位1.Hagedorn Res Inst, DK-2820 Gentofte, Denmark
2.Univ Copenhagen, Dept Biol, DK-2200 Copenhagen, Denmark
3.BGI Shenzhen, Shenzhen 518083, Peoples R China
4.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen 518035, Peoples R China
5.Peking Univ, Shenzhen Hosp, Shenzhen 518036, Peoples R China
6.Guangdong Acad Med Sci, Guangdong Gen Hosp, Med Res Ctr, Guangzhou 510080, Peoples R China
7.Univ Copenhagen, Fac Hlth Sci, Novo Nordisk Fdn Ctr Basic Metab Res, DK-2100 Copenhagen, Denmark
8.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94820 USA
9.Univ Calif Berkeley, Dept Stat, Berkeley, CA 94820 USA
10.VIB, Dept Biol Struct, B-1050 Brussels, Belgium
11.Vrije Univ Brussel, Dept Appl Biol Sci DBIT, B-1050 Brussels, Belgium
12.Inst Natl Rech Agron, F-78350 Jouy En Josas, France
13.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
14.Univ Copenhagen, Inst Biomed Sci, DK-8000 Aarhus, Denmark
15.Univ Aarhus, Fac Hlth Sci, DK-8000 Aarhus, Denmark
16.Hagedorn Res Inst, DK-2820 Gentofte, Denmark
推荐引用方式
GB/T 7714
Qin, Junjie,Li, Yingrui,Cai, Zhiming,et al. A metagenome-wide association study of gut microbiota in type 2 diabetes[J]. NATURE,2012,490(7418):55-60.
APA Qin, Junjie.,Li, Yingrui.,Cai, Zhiming.,Li, Shenghui.,Zhu, Jianfeng.,...&Wang, Jun.(2012).A metagenome-wide association study of gut microbiota in type 2 diabetes.NATURE,490(7418),55-60.
MLA Qin, Junjie,et al."A metagenome-wide association study of gut microbiota in type 2 diabetes".NATURE 490.7418(2012):55-60.
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