北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学深圳医院  > 期刊论文
学科主题: 临床医学
题名:
A metagenome-wide association study of gut microbiota in type 2 diabetes
作者: Qin, Junjie1; Li, Yingrui1; Cai, Zhiming2; Li, Shenghui1; Zhu, Jianfeng1; Zhang, Fan3; Liang, Suisha1; Zhang, Wenwei1; Guan, Yuanlin1; Shen, Dongqian1; Peng, Yangqing1; Zhang, Dongya1; Jie, Zhuye1; Wu, Wenxian1; Qin, Youwen1; Xue, Wenbin1; Li, Junhua1; Han, Lingchuan3; Lu, Donghui3; Wu, Peixian3; Dai, Yali3; Sun, Xiaojuan3; Li, Zesong2; Tang, Aifa2; Zhong, Shilong2; Li, Xiaoping4; Chen, Weineng1; Xu, Ran1; Wang, Mingbang1; Feng, Qiang1; Gong, Meihua1; Yu, Jing1; Zhang, Yanyan1; Zhang, Ming1; Hansen, Torben5; Sanchez, Gaston6,7; Raes, Jeroen8,9; Falony, Gwen8,9; Okuda, Shujiro8,9; Almeida, Mathieu10; LeChatelier, Emmanuelle10; Renault, Pierre10; Pons, Nicolas10; Batto, Jean-Michel10; Zhang, Zhaoxi1; Chen, Hua1; Yang, Ruifu1,11; Zheng, Weimou1; Li, Songgang1; Yang, Huanming1; Wang, Jian1; Ehrlich, S. Dusko10; Nielsen, Rasmus6,7; Pedersen, Oluf5,12,13,14,15; Kristiansen, Karsten1,16; Wang, Jun1,5,16
刊名: NATURE
发表日期: 2012-10-04
DOI: 10.1038/nature11450
卷: 490, 期:7418, 页:55-60
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: OBESITY ; DIVERSITY ; BACTEREMIA ; FRAGMENTS ; INFECTION ; VARIANTS ; DISEASE ; STRESS ; MICE
英文摘要:

Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To carry out analysis on gut microbial content in patients with type 2 diabetes, we developed a protocol for a metagenome-wide association study (MGWAS) and undertook a two-stage MGWAS based on deep shotgun sequencing of the gut microbial DNA from 345 Chinese individuals. We identified and validated approximately 60,000 type-2-diabetes-associated markers and established the concept of a metagenomic linkage group, enabling taxonomic species-level analyses. MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance. An analysis of 23 additional individuals demonstrated that these gut microbial markers might be useful for classifying type 2 diabetes.

语种: 英语
所属项目编号: 2012AA02A201 ; 30890032 ; 30725008 ; 30811130531 ; 31161130357 ; ZYC200903240080A ; BGI20100001 ; CXB201108250096A ; CXB201108250098A ; 2106-07-0021 ; 272-07-0196 ; HEALTH-F4-2007-201052
项目资助者: Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Shenzhen Municipal Government of China ; Danish Strategic Research Council ; Danish Natural Science Research Council ; Solexa project ; European Commission ; Novo Nordisk Foundation
WOS记录号: WOS:000309446800031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57376
Appears in Collections:北京大学深圳医院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Hagedorn Res Inst, DK-2820 Gentofte, Denmark
2.Univ Copenhagen, Dept Biol, DK-2200 Copenhagen, Denmark
3.BGI Shenzhen, Shenzhen 518083, Peoples R China
4.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen 518035, Peoples R China
5.Peking Univ, Shenzhen Hosp, Shenzhen 518036, Peoples R China
6.Guangdong Acad Med Sci, Guangdong Gen Hosp, Med Res Ctr, Guangzhou 510080, Peoples R China
7.Univ Copenhagen, Fac Hlth Sci, Novo Nordisk Fdn Ctr Basic Metab Res, DK-2100 Copenhagen, Denmark
8.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94820 USA
9.Univ Calif Berkeley, Dept Stat, Berkeley, CA 94820 USA
10.VIB, Dept Biol Struct, B-1050 Brussels, Belgium
11.Vrije Univ Brussel, Dept Appl Biol Sci DBIT, B-1050 Brussels, Belgium
12.Inst Natl Rech Agron, F-78350 Jouy En Josas, France
13.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
14.Univ Copenhagen, Inst Biomed Sci, DK-8000 Aarhus, Denmark
15.Univ Aarhus, Fac Hlth Sci, DK-8000 Aarhus, Denmark
16.Hagedorn Res Inst, DK-2820 Gentofte, Denmark

Recommended Citation:
Qin, Junjie,Li, Yingrui,Cai, Zhiming,et al. A metagenome-wide association study of gut microbiota in type 2 diabetes[J]. NATURE,2012,490(7418):55-60.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Qin, Junjie]'s Articles
[Li, Yingrui]'s Articles
[Cai, Zhiming]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Qin, Junjie]‘s Articles
[Li, Yingrui]‘s Articles
[Cai, Zhiming]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace