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A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, Junjie1; Li, Yingrui1; Cai, Zhiming2; Li, Shenghui1; Zhu, Jianfeng1; Zhang, Fan3; Liang, Suisha1; Zhang, Wenwei1; Guan, Yuanlin1; Shen, Dongqian1
Source PublicationNATURE
2012-10-04
Volume490Issue:7418Pages:55-60
Indexed BySCI
Abstract

Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To carry out analysis on gut microbial content in patients with type 2 diabetes, we developed a protocol for a metagenome-wide association study (MGWAS) and undertook a two-stage MGWAS based on deep shotgun sequencing of the gut microbial DNA from 345 Chinese individuals. We identified and validated approximately 60,000 type-2-diabetes-associated markers and established the concept of a metagenomic linkage group, enabling taxonomic species-level analyses. MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance. An analysis of 23 additional individuals demonstrated that these gut microbial markers might be useful for classifying type 2 diabetes.

Subject Area临床医学
SubtypeArticle
DOI10.1038/nature11450
WOS HeadingsScience & Technology
Language英语
Funding OrganizationMinistry of Science and Technology of China ; National Natural Science Foundation of China ; Shenzhen Municipal Government of China ; Danish Strategic Research Council ; Danish Natural Science Research Council ; Solexa project ; European Commission ; Novo Nordisk Foundation
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS KeywordOBESITY ; DIVERSITY ; BACTEREMIA ; FRAGMENTS ; INFECTION ; VARIANTS ; DISEASE ; STRESS ; MICE
WOS IDWOS:000309446800031
Citation statistics
Cited Times:3036[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.bjmu.edu.cn/handle/400002259/57376
Collection北京大学深圳医院
北京大学第三临床医学院_核医学科
Affiliation1.Hagedorn Res Inst, DK-2820 Gentofte, Denmark
2.Univ Copenhagen, Dept Biol, DK-2200 Copenhagen, Denmark
3.BGI Shenzhen, Shenzhen 518083, Peoples R China
4.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen 518035, Peoples R China
5.Peking Univ, Shenzhen Hosp, Shenzhen 518036, Peoples R China
6.Guangdong Acad Med Sci, Guangdong Gen Hosp, Med Res Ctr, Guangzhou 510080, Peoples R China
7.Univ Copenhagen, Fac Hlth Sci, Novo Nordisk Fdn Ctr Basic Metab Res, DK-2100 Copenhagen, Denmark
8.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94820 USA
9.Univ Calif Berkeley, Dept Stat, Berkeley, CA 94820 USA
10.VIB, Dept Biol Struct, B-1050 Brussels, Belgium
Recommended Citation
GB/T 7714
Qin, Junjie,Li, Yingrui,Cai, Zhiming,et al. A metagenome-wide association study of gut microbiota in type 2 diabetes[J]. NATURE,2012,490(7418):55-60.
APA Qin, Junjie.,Li, Yingrui.,Cai, Zhiming.,Li, Shenghui.,Zhu, Jianfeng.,...&Wang, Jun.(2012).A metagenome-wide association study of gut microbiota in type 2 diabetes.NATURE,490(7418),55-60.
MLA Qin, Junjie,et al."A metagenome-wide association study of gut microbiota in type 2 diabetes".NATURE 490.7418(2012):55-60.
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