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学科主题临床医学
Inhibition of taurine transport by high concentration of glucose in cultured rat cardiomyocytes
Shi, YR; Gao, L; Wang, SH; Bu, DF; Zhang, BH; Jiang, HF; Pang, YZ; Tang, CS
刊名METABOLISM-CLINICAL AND EXPERIMENTAL
2003-07-01
DOI10.1016/S0026-0495(03)00067-2
52期:7页:827-833
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]CYSTEINE SULFINATE DECARBOXYLASE ; BIOSYNTHETIC-ENZYMES ; DIABETES-MELLITUS ; GENE-EXPRESSION ; MESSENGER-RNA ; RETINA ; KIDNEY ; BRAIN ; CELLS
英文摘要

Cultured rat cardiomyocytes were treated with 10, 20, and 30 mmol/L glucose and 30 mmol/L glucose plus protein kinase C (PKC) inhibitor, Chelerythrine. In the 20 and 30 mmol/L glucose-treated cells, taurine contents reduced by 15% and 27% (P < .05), respectively, taurine transporter (TAUT) mRNA levels reduced by 47% and 64% (P < .05), respectively, and cysteine sulfinate decarboxylase (CSD) mRNA reduced slightly, but not significantly. Time-dependent taurine uptakes reduced in the 10, 20, and 30 mmol/L glucose-treated cells, and time-dependent taurine release reduced in the 30 mmol/L glucose-treated cells. The V-max of taurine transport decreased by 18%, 30%, and 35% (P < .05) in the 10, 20, and 30 mmol/L glucose-treated cells, respectively, while K-m of taurine transport remained unchanged. When PKC inhibitor, Chelerythrine, combined with 30 mmol/L glucose was treated with the cells, the lowered taurine content, taurine uptake, taurine release, and V-max of taurine transport caused by 30 mmol/L glucose were eliminated. These results demonstrate that high glucose considerably and specifically decreases intracellular taurine content, taurine transport activity, and TAUT mRNA, possibly through PKC-mediated transcriptional and posttranslational pathways. (C) 2003 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000184197500005
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57382
专题北京大学第一临床医学院_心血管内科
作者单位Peking Univ, Hosp 1, Inst Cardiovasc Dis Res, Beijing 100034, Peoples R China
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GB/T 7714
Shi, YR,Gao, L,Wang, SH,et al. Inhibition of taurine transport by high concentration of glucose in cultured rat cardiomyocytes[J]. METABOLISM-CLINICAL AND EXPERIMENTAL,2003,52(7):827-833.
APA Shi, YR.,Gao, L.,Wang, SH.,Bu, DF.,Zhang, BH.,...&Tang, CS.(2003).Inhibition of taurine transport by high concentration of glucose in cultured rat cardiomyocytes.METABOLISM-CLINICAL AND EXPERIMENTAL,52(7),827-833.
MLA Shi, YR,et al."Inhibition of taurine transport by high concentration of glucose in cultured rat cardiomyocytes".METABOLISM-CLINICAL AND EXPERIMENTAL 52.7(2003):827-833.
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