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学科主题: 临床医学
题名:
Differential susceptibility to carbapenems due to the AdcABC efflux pump among nosocomial outbreak isolates of Acinetobacter baumannii in a Chinese hospital
作者: Huang, Lei; Sun, Liying; Xu, Guobing; Xia, Tiean
关键词: Acinetobacter baumannii ; Nosocomial outbreak ; Carbapenem resistance ; Efflux pump ; adeB gene
刊名: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
发表日期: 2008-11-01
DOI: 10.1016/j.diagmicrobio.2008.06.008
卷: 62, 期:3, 页:326-332
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Microbiology
研究领域[WOS]: Infectious Diseases ; Microbiology
关键词[WOS]: SPECTRUM BETA-LACTAMASE ; PSEUDOMONAS-AERUGINOSA ; IMIPENEM RESISTANCE ; CLINICAL STRAINS ; DISSEMINATION ; EPIDEMIOLOGY ; SYSTEM ; GENES ; ADEB ; SPP.
英文摘要:

A nosocomial outbreak of carbapenem-resistant Acinetobacter baumannii occurred from February to November 2004 in the surgical intensive care unit (SICU) and the pediatric intensive care unit (PICU) of our hospital. Two separate clones prevailed, the antimicrobial susceptibility profiles of which were different. The PICU isolates produced OXA-23 oxacillinase, whereas no carbapenemases were detected from SICU isolates. No obvious outer membrane protein change was seen. Efflux pump phenotype was detected from SICU isolates. Efflux pump-encoding gene adeB was positive in these isolates and negative in PICU isolates. Through further study, we found that AdeABC efflux system gene contents were common in the SICU isolates. Then we compared the expression level of adeB in resistant and susceptible isolates using quantitative real-time polymerase chain reaction and found that increased expression of AdeABC efflux pump may play an important role in reduced meropenem susceptibility among A. baumannii in the SICU of our hospital. (C) 2008 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000260736900012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57385
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China

Recommended Citation:
Huang, Lei,Sun, Liying,Xu, Guobing,et al. Differential susceptibility to carbapenems due to the AdcABC efflux pump among nosocomial outbreak isolates of Acinetobacter baumannii in a Chinese hospital[J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE,2008,62(3):326-332.
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