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Differential susceptibility to carbapenems due to the AdcABC efflux pump among nosocomial outbreak isolates of Acinetobacter baumannii in a Chinese hospital
Huang, Lei; Sun, Liying; Xu, Guobing; Xia, Tiean
关键词Acinetobacter Baumannii Nosocomial Outbreak Carbapenem Resistance Efflux Pump Adeb Gene
刊名DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
2008-11-01
DOI10.1016/j.diagmicrobio.2008.06.008
62期:3页:326-332
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Microbiology
研究领域[WOS]Infectious Diseases ; Microbiology
关键词[WOS]SPECTRUM BETA-LACTAMASE ; PSEUDOMONAS-AERUGINOSA ; IMIPENEM RESISTANCE ; CLINICAL STRAINS ; DISSEMINATION ; EPIDEMIOLOGY ; SYSTEM ; GENES ; ADEB ; SPP.
英文摘要

A nosocomial outbreak of carbapenem-resistant Acinetobacter baumannii occurred from February to November 2004 in the surgical intensive care unit (SICU) and the pediatric intensive care unit (PICU) of our hospital. Two separate clones prevailed, the antimicrobial susceptibility profiles of which were different. The PICU isolates produced OXA-23 oxacillinase, whereas no carbapenemases were detected from SICU isolates. No obvious outer membrane protein change was seen. Efflux pump phenotype was detected from SICU isolates. Efflux pump-encoding gene adeB was positive in these isolates and negative in PICU isolates. Through further study, we found that AdeABC efflux system gene contents were common in the SICU isolates. Then we compared the expression level of adeB in resistant and susceptible isolates using quantitative real-time polymerase chain reaction and found that increased expression of AdeABC efflux pump may play an important role in reduced meropenem susceptibility among A. baumannii in the SICU of our hospital. (C) 2008 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000260736900012
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被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57385
专题北京大学第一临床医学院
北京大学第一临床医学院_检验科
作者单位Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China
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GB/T 7714
Huang, Lei,Sun, Liying,Xu, Guobing,et al. Differential susceptibility to carbapenems due to the AdcABC efflux pump among nosocomial outbreak isolates of Acinetobacter baumannii in a Chinese hospital[J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE,2008,62(3):326-332.
APA Huang, Lei,Sun, Liying,Xu, Guobing,&Xia, Tiean.(2008).Differential susceptibility to carbapenems due to the AdcABC efflux pump among nosocomial outbreak isolates of Acinetobacter baumannii in a Chinese hospital.DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE,62(3),326-332.
MLA Huang, Lei,et al."Differential susceptibility to carbapenems due to the AdcABC efflux pump among nosocomial outbreak isolates of Acinetobacter baumannii in a Chinese hospital".DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 62.3(2008):326-332.
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