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Bimetallic AuPt nanochains: Synthesis and their application in electrochemical immunosensor for the detection of carcinoembryonic antigen
Cao, Xia2; Wang, Ning1; Jia, Shu1; Guo, Lin1; Li, Ke3
关键词Aupt Alloy Nanochain Immunoassay Sandwich-type Cea
刊名BIOSENSORS & BIOELECTRONICS
2013-01-15
DOI10.1016/j.bios.2012.07.046
39期:1页:226-230
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology
研究领域[WOS]Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
关键词[WOS]HYBRID NANOCOMPOSITE ; TUMOR-MARKERS ; SENSOR ; NANOPARTICLES ; ELECTRODE ; LABELS
英文摘要

The recent development in the nanotechnology has paved the way for a large number of alloyed nanomaterials and devices of desirable properties which have useful functions for electrochemical sensor and biosensor applications. In this paper, bimetallic AuPt nanochains were synthesized through a mild chemical method, with which anti-horseradish peroxidase-conjugated anti-carcinoembryonic antigen (HRP-anti-CEA-NCAuPt) was developed for electrochemical detection of carcinoembryonic antigen (CEA) in a sandwich-type immunoassay format. The alloyed nanocrystals exhibit not only sound signal amplification effect of Au nanoparticles, but also further new combination of interfacial, electrical and structural properties arising from the disparate AuPt components. As a result, the electrochemical signal was significantly amplified by using the HRP-anti-CEA-NCAuPt as tracer and hydrogen peroxide as enzyme substrate. The linear range of the developed immunosensor is 0.01-200 ng/mL and the detection limit is 0.11 pg/mL of CEA, which makes the biometallic nanochains promising candidates for the next-generation sandwich-type electrochemical immunoassays. (C) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000309486300037
项目编号21173017 ; 50902007 ; 21275102 ; BK2010341 ; 2010CB934701
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; 973 Program
引用统计
被引频次:66[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57389
专题北京大学第三临床医学院_消化科
作者单位1.Beijing Univ Aeronaut & Astronaut, Sch Chem & Environm, Beijing 100083, Peoples R China
2.Capital Med Univ, Sch Biochem & Pharmaceut Sci, Beijing 100069, Peoples R China
3.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Cao, Xia,Wang, Ning,Jia, Shu,et al. Bimetallic AuPt nanochains: Synthesis and their application in electrochemical immunosensor for the detection of carcinoembryonic antigen[J]. BIOSENSORS & BIOELECTRONICS,2013,39(1):226-230.
APA Cao, Xia,Wang, Ning,Jia, Shu,Guo, Lin,&Li, Ke.(2013).Bimetallic AuPt nanochains: Synthesis and their application in electrochemical immunosensor for the detection of carcinoembryonic antigen.BIOSENSORS & BIOELECTRONICS,39(1),226-230.
MLA Cao, Xia,et al."Bimetallic AuPt nanochains: Synthesis and their application in electrochemical immunosensor for the detection of carcinoembryonic antigen".BIOSENSORS & BIOELECTRONICS 39.1(2013):226-230.
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