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Review article: Pathogenic role of complement activation in anti-neutrophil cytoplasmic auto-antibody-associated vasculitis
作者: Van Timmeren, Mirjan M.1,2; Chen, Min3; Heeringa, Peter1,2
关键词: alternative complement pathway ; anti-MPO ; anti-Pr3 ; neutrophil ; rapidly progressive glomerulonephritis
刊名: NEPHROLOGY
发表日期: 2009-02-01
DOI: 10.1111/j.1440-1797.2009.01086.x
卷: 14, 期:1, 页:16-25
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: HUMAN POLYMORPHONUCLEAR LEUKOCYTES ; COLLAGEN-INDUCED ARTHRITIS ; C5A RECEPTOR ANTAGONIST ; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; INTERACTIONS IN-VIVO ; WEGENERS-GRANULOMATOSIS ; ANTIMYELOPEROXIDASE ANTIBODIES ; CRESCENTIC GLOMERULONEPHRITIS ; ISCHEMIA-REPERFUSION ; ALTERNATIVE PATHWAY
英文摘要:

Small-vessel vasculitides associated with anti-neutrophil cytoplasmic auto-antibodies (ANCA) are severe systemic diseases that may affect any organ. Increasing evidence from clinical, animal and in vitro studies indicates that ANCA are causally involved in disease pathogenesis mainly through activation of neutrophils resulting in endothelial cell injury. Recent studies suggest a previously unsuspected but crucial role for alternative pathway complement activation in ANCA disease pathogenesis. In this brief review, we will discuss the evidence for complement system activation in ANCA-associated vasculitides and propose a working model that links ANCA, neutrophils and complement activation in causing an inflammatory amplification loop that may explain the severe leukocytoclastic inflammation that is typical for ANCA-associated vasculitis.

语种: 英语
所属项目编号: 985-2-104-113 ; C07-2204 ; 917.66.341
项目资助者: Chinese 985 Project ; Dutch Kidney Foundation ; Netherlands Organization for Scientific Research
WOS记录号: WOS:000264552700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57394
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Univ Groningen, Groningen, Netherlands
2.Univ Med Ctr Groningen, Dept Pathol & Med Biol, NL-9713 GZ Groningen, Netherlands
3.Peking Univ, Dept Nephrol, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Van Timmeren, Mirjan M.,Chen, Min,Heeringa, Peter. Review article: Pathogenic role of complement activation in anti-neutrophil cytoplasmic auto-antibody-associated vasculitis[J]. NEPHROLOGY,2009,14(1):16-25.
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