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Review article: Pathogenic role of complement activation in anti-neutrophil cytoplasmic auto-antibody-associated vasculitis
Van Timmeren, Mirjan M.1,2; Chen, Min3; Heeringa, Peter1,2
关键词Alternative Complement Pathway Anti-mpo Anti-pr3 Neutrophil Rapidly Progressive Glomerulonephritis
刊名NEPHROLOGY
2009-02-01
DOI10.1111/j.1440-1797.2009.01086.x
14期:1页:16-25
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
资助者Chinese 985 Project ; Dutch Kidney Foundation ; Netherlands Organization for Scientific Research ; Chinese 985 Project ; Dutch Kidney Foundation ; Netherlands Organization for Scientific Research
研究领域[WOS]Urology & Nephrology
关键词[WOS]HUMAN POLYMORPHONUCLEAR LEUKOCYTES ; COLLAGEN-INDUCED ARTHRITIS ; C5A RECEPTOR ANTAGONIST ; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; INTERACTIONS IN-VIVO ; WEGENERS-GRANULOMATOSIS ; ANTIMYELOPEROXIDASE ANTIBODIES ; CRESCENTIC GLOMERULONEPHRITIS ; ISCHEMIA-REPERFUSION ; ALTERNATIVE PATHWAY
英文摘要

Small-vessel vasculitides associated with anti-neutrophil cytoplasmic auto-antibodies (ANCA) are severe systemic diseases that may affect any organ. Increasing evidence from clinical, animal and in vitro studies indicates that ANCA are causally involved in disease pathogenesis mainly through activation of neutrophils resulting in endothelial cell injury. Recent studies suggest a previously unsuspected but crucial role for alternative pathway complement activation in ANCA disease pathogenesis. In this brief review, we will discuss the evidence for complement system activation in ANCA-associated vasculitides and propose a working model that links ANCA, neutrophils and complement activation in causing an inflammatory amplification loop that may explain the severe leukocytoclastic inflammation that is typical for ANCA-associated vasculitis.

语种英语
所属项目编号985-2-104-113 ; C07-2204 ; 917.66.341
资助者Chinese 985 Project ; Dutch Kidney Foundation ; Netherlands Organization for Scientific Research ; Chinese 985 Project ; Dutch Kidney Foundation ; Netherlands Organization for Scientific Research
WOS记录号WOS:000264552700004
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57394
专题北京大学第一临床医学院_肾脏内科
作者单位1.Univ Groningen, Groningen, Netherlands
2.Univ Med Ctr Groningen, Dept Pathol & Med Biol, NL-9713 GZ Groningen, Netherlands
3.Peking Univ, Dept Nephrol, Hosp 1, Beijing 100871, Peoples R China
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GB/T 7714
Van Timmeren, Mirjan M.,Chen, Min,Heeringa, Peter. Review article: Pathogenic role of complement activation in anti-neutrophil cytoplasmic auto-antibody-associated vasculitis[J]. NEPHROLOGY,2009,14(1):16-25.
APA Van Timmeren, Mirjan M.,Chen, Min,&Heeringa, Peter.(2009).Review article: Pathogenic role of complement activation in anti-neutrophil cytoplasmic auto-antibody-associated vasculitis.NEPHROLOGY,14(1),16-25.
MLA Van Timmeren, Mirjan M.,et al."Review article: Pathogenic role of complement activation in anti-neutrophil cytoplasmic auto-antibody-associated vasculitis".NEPHROLOGY 14.1(2009):16-25.
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