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学科主题: 药学
题名:
Determination of absolute configuration of alpha-hydroxy ketones using NMR
作者: Yang Chun-Hui; Chen Jing-Wen; Li Qin; Peng Kun; Pan Xin-Fu; Cui Yu-Xin
关键词: alpha-hydroxy ketones ; absolute configuration ; Mosher&prime ; s method ; NMR
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2006-07-01
卷: 27, 期:7, 页:1295-1297
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: OXIDATION
英文摘要:

alpha-Hydroxy ketones are frequently involved in biologically important compounds and, therefore, the determination of the stereochemistry of these structural elements has attracted the attention in natural products′ chemistry. In this paper a simpler Mosher′s method was developed from the modified Mosher′s method. It only need one configuration of MTPA to determine the absolute configurations of four a-hydroxy ketones with their (S)- and (R)-MTPA esters using H-1 NMR. The signals of protons on the same side with phenyl ring will be in the higher field than those of on the different side ones. Consequently according to the model the main configuration of compounds 1, 2, 3 and 4 were determined as S, R, R and S, respectively.

语种: 中文
WOS记录号: WOS:000239259000027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57396
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Lanzhou Univ, Dept Chem, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
3.Peking Univ, Med & Healthy Anal Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Yang Chun-Hui,Chen Jing-Wen,Li Qin,et al. Determination of absolute configuration of alpha-hydroxy ketones using NMR[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2006,27(7):1295-1297.
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