IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
A Role for the Clock Gene Per1 in Prostate Cancer
Cao, Qi1,2; Gery, Sigal1; Dashti, Azadeh1; Yin, Dong1; Zhou, Yan2; Gu, Jiang2,3; Koeffler, H. Phiflip1
刊名CANCER RESEARCH
2009-10-01
DOI10.1158/0008-5472.CAN-08-4199
69期:19页:7619-7625
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者NIH ; C. Koeffler finds, Inger Foundation ; China Scholarship Council ; NIH ; C. Koeffler finds, Inger Foundation ; China Scholarship Council
研究领域[WOS]Oncology
关键词[WOS]NIGHT-SHIFT WORK ; MAMMALIAN CIRCADIAN CLOCK ; TUMOR-SUPPRESSOR ; BREAST-CANCER ; IN-VIVO ; EXPRESSION ; RISK ; TRANSCRIPTION ; CELLS ; OSCILLATORS
英文摘要

Circadian rhythms regulate diverse physiologic processes, including homeostatic functions of steroid hormones and their receptors. Perturbations of these rhythms are associated with pathogenic conditions, such as depression, diabetes, and cancer. Androgens play an important role in both normal development and carcinogenesis of the prostate. In the present study, we investigated a potential role for the core clock factor Per1 in the pathogenesis of prostate cancer. Serum-shocked synchronized prostate cancer cells displayed disrupted circadian rhythms compared with the normal prostate tissue. Using Oncomine to perform a meta-analysis of microarray expression studies, we found that Per1 is down-regulated in human prostate cancer samples compared with normal prostates. Reporter assays showed that Per1 inhibited transactivation of the androgen receptor (AR) both in 293T cells overexpressing the AR and in the prostate cancer cell line LNCaP. Forced expression of Per1 in LNCaP cells diminished the expression of known androgen-sensitive genes following stimulation with dihydrotestosterone. We showed that Per1 physically interacted with AR; in addition, we found that Per1 itself is regulated by androgens in prostate cancer cells. Overexpression of Per1 in prostate cancer cells resulted in significant growth inhibition and apoptosis. Our results support the emerging role of circadian genes as key players in malignant transformation. Further elucidating the connections between clock genes and the AR pathway could benefit the development of new therapeutic strategies for prostate cancer as well as provide insights into chronotherapy as away to optimize current therapies. [Cancer Res 2009;69(19):7619-25]

语种英语
资助者NIH ; C. Koeffler finds, Inger Foundation ; China Scholarship Council ; NIH ; C. Koeffler finds, Inger Foundation ; China Scholarship Council
WOS记录号WOS:000270487600019
Citation statistics
Cited Times:70[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57398
Collection北京大学基础医学院_病理学系
作者单位1.Shantou Univ, Coll Med, Shantou, Peoples R China
2.Univ Calif Los Angeles, Cedars Sinai Med Ctr, Div Hematol Oncol, Sch Med, Los Angeles, CA 90048 USA
3.Peking Univ, Dept Pathol, Sch Basic Med Sci, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Cao, Qi,Gery, Sigal,Dashti, Azadeh,et al. A Role for the Clock Gene Per1 in Prostate Cancer[J]. CANCER RESEARCH,2009,69(19):7619-7625.
APA Cao, Qi.,Gery, Sigal.,Dashti, Azadeh.,Yin, Dong.,Zhou, Yan.,...&Koeffler, H. Phiflip.(2009).A Role for the Clock Gene Per1 in Prostate Cancer.CANCER RESEARCH,69(19),7619-7625.
MLA Cao, Qi,et al."A Role for the Clock Gene Per1 in Prostate Cancer".CANCER RESEARCH 69.19(2009):7619-7625.
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