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学科主题: 临床医学
题名:
A piRNA-like small RNA interacts with and modulates p-ERM pr !E lls
作者: Mei, Yuping1; Wang, Yuyan1,2; Kumari, Priti3; Shetty, Amol Carl3; Clark, David1; Gable, Tyler1; MacKerell, Alexander D.4,5; Ma, Mark Z.1; Weber, David J.5,6; Yang, Austin J.5; Edelman, Martin J.5; Mao, Li1,5
刊名: NATURE COMMUNICATIONS
发表日期: 2015-06-01
DOI: 10.1038/ncomms8316
卷: 6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ACTIN-BINDING-SITE ; C. ELEGANS ; CAENORHABDITIS-ELEGANS ; EPIGENETIC MEMORY ; SELF-ASSOCIATION ; PIWI PROTEINS ; EZRIN ; GERMLINE ; MEMBRANE ; CORTEX
英文摘要:

PIWI-interacting RNAs (piRNAs) are thought to silence transposon and gene expression during development. However, the roles of piRNAs in somatic tissues are largely unknown. Here we report the identification of 555 piRNAs in human lung bronchial epithelial (HBE) and non-small cell lung cancer (NSCLC) cell lines, including 295 that do not exist in databases termed as piRNA-like sncRNAs or piRNA-Ls. Distinctive piRNA/piRNA-L expression patterns are observed between HBE and NSCLC cells. piRNA-like-163 (piR-L-163), the top downregulated piRNA-L in NSCLC cells, binds directly to phosphorylated ERM proteins (p-ERM), which is dependent on the central part of UUNNUUUNNUU motif in piR-L-163 and the RRRKPDT element in ERM. The piR-L-163/p-ERM interaction is critical for p-ERM′s binding capability to filamentous actin (F-actin) and ERM-binding phosphoprotein 50 (EBP50). Thus, piRNA/piRNA-L may play a regulatory role through direct interaction with proteins in physiological and pathophysiological conditions.

语种: 英语
WOS记录号: WOS:000357171600020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57400
Appears in Collections:北京大学临床肿瘤学院_胸部肿瘤内科_期刊论文

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作者单位: 1.Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA
2.Univ Maryland, Sch Med, Dept Biochem & Mol Biol, Baltimore, MD 21201 USA
3.Univ Maryland, Sch Dent, Dept Oncol & Diagnost Sci, Baltimore, MD 21201 USA
4.Peking Univ, Canc Hosp & Inst, Dept Thorac Med Oncol, Beijing 100142, Peoples R China
5.Univ Maryland, Sch Pharm, Comp Aided Drug Design Ctr, Dept Pharmaceut Sci, Baltimore, MD 21201 USA
6.Univ Maryland, Marlene & Stewart Greenebaum Canc Ctr, Baltimore, MD 21201 USA

Recommended Citation:
Mei, Yuping,Wang, Yuyan,Kumari, Priti,et al. A piRNA-like small RNA interacts with and modulates p-ERM proteins in human somatic cells[J]. NATURE COMMUNICATIONS,2015,6.
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