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学科主题: 临床医学
题名:
Expression of 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase-2 in non-small cell lung cancer: Correlations with angiogenesis and prognosis
作者: Li, Ying1; Li, Suli2; Sun, Dan3; Song, Linlin3; Liu, Xinmin3
关键词: non-small cell lung cancer ; 15-hydroxyprostaglandin dehydrogenase ; cyclooxygenase-2 ; angiogenesis ; prognosis
刊名: ONCOLOGY LETTERS
发表日期: 2014-10-01
DOI: 10.3892/ol.2014.2371
卷: 8, 期:4, 页:1589-1594
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; COLORECTAL-CANCER ; TUMOR-SUPPRESSOR ; GASTRIC-CANCER ; HEPATOCELLULAR-CARCINOMA ; PROMOTE ANGIOGENESIS ; MICROVESSEL DENSITY ; PROSTAGLANDIN E-2 ; BREAST-CANCER ; BETA-CATENIN
英文摘要:

The aim of the present study was to investigate the function of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and cyclooxygenase-2 (COX-2) in angiogenesis and their association with the prognosis of non-small cell lung cancer (NSCLC). Using immunohistochemical staining, the expression of 15-PGDH and COX-2, and the microvessel density (MVD) levels were evaluated in 35 NSCLC specimens. Paracancerous normal lung tissue was collected as control samples from six patients. The correlation of 15-PGDH with COX-2, clinicopathological characteristics, MVD and overall survival (OS) was studied. NSCLC tissues showed a significantly lower expression level of 15-PGDH (P=0.009) and a significantly higher expression level of COX-2 (P=0.004) compared with normal lung tissue. The expression level of 15-PGDH was negatively correlated with MVD (P<0.001) and COX-2 expression (P=0.032). A low expression level of 15-PGDH, a high expression level of COX-2 and high levels of MVD were significantly correlated with a shorter OS time (15-PGDH, P<0.0001; COX-2, P=0.038; MVD, P<0.0001). This study provided clinical evidence that a low expression level of 15-PGDH is associated with a poor prognosis in NSCLC. Furthermore, it was shown that 15-PGDH and COX-2 reciprocally regulate cancer angiogenesis, which may affect the prognosis of patients with NSCLC.

语种: 英语
WOS记录号: WOS:000342725400034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57405
Appears in Collections:北京大学第一临床医学院_老年病内科_期刊论文

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作者单位: 1.Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, West China Med Sch, Chengdu 610041, Sichuan, Peoples R China
2.Sichuan Univ, West China Hosp, Natl Key Lab Biotherapy, West China Med Sch, Chengdu 610041, Sichuan, Peoples R China
3.Peking Univ, Hosp 1, Dept Geriatr, Beijing 100034, Peoples R China

Recommended Citation:
Li, Ying,Li, Suli,Sun, Dan,et al. Expression of 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase-2 in non-small cell lung cancer: Correlations with angiogenesis and prognosis[J]. ONCOLOGY LETTERS,2014,8(4):1589-1594.
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