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学科主题临床医学
Expression of 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase-2 in non-small cell lung cancer: Correlations with angiogenesis and prognosis
Li, Ying1; Li, Suli2; Sun, Dan3; Song, Linlin3; Liu, Xinmin3
关键词Non-small Cell Lung Cancer 15-hydroxyprostaglandin Dehydrogenase Cyclooxygenase-2 Angiogenesis Prognosis
刊名ONCOLOGY LETTERS
2014-10-01
DOI10.3892/ol.2014.2371
8期:4页:1589-1594
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; COLORECTAL-CANCER ; TUMOR-SUPPRESSOR ; GASTRIC-CANCER ; HEPATOCELLULAR-CARCINOMA ; PROMOTE ANGIOGENESIS ; MICROVESSEL DENSITY ; PROSTAGLANDIN E-2 ; BREAST-CANCER ; BETA-CATENIN
英文摘要

The aim of the present study was to investigate the function of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and cyclooxygenase-2 (COX-2) in angiogenesis and their association with the prognosis of non-small cell lung cancer (NSCLC). Using immunohistochemical staining, the expression of 15-PGDH and COX-2, and the microvessel density (MVD) levels were evaluated in 35 NSCLC specimens. Paracancerous normal lung tissue was collected as control samples from six patients. The correlation of 15-PGDH with COX-2, clinicopathological characteristics, MVD and overall survival (OS) was studied. NSCLC tissues showed a significantly lower expression level of 15-PGDH (P=0.009) and a significantly higher expression level of COX-2 (P=0.004) compared with normal lung tissue. The expression level of 15-PGDH was negatively correlated with MVD (P<0.001) and COX-2 expression (P=0.032). A low expression level of 15-PGDH, a high expression level of COX-2 and high levels of MVD were significantly correlated with a shorter OS time (15-PGDH, P<0.0001; COX-2, P=0.038; MVD, P<0.0001). This study provided clinical evidence that a low expression level of 15-PGDH is associated with a poor prognosis in NSCLC. Furthermore, it was shown that 15-PGDH and COX-2 reciprocally regulate cancer angiogenesis, which may affect the prognosis of patients with NSCLC.

语种英语
WOS记录号WOS:000342725400034
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57405
专题北京大学第一临床医学院_麻醉科
北京大学第一临床医学院_老年病内科
作者单位1.Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, West China Med Sch, Chengdu 610041, Sichuan, Peoples R China
2.Sichuan Univ, West China Hosp, Natl Key Lab Biotherapy, West China Med Sch, Chengdu 610041, Sichuan, Peoples R China
3.Peking Univ, Hosp 1, Dept Geriatr, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Li, Ying,Li, Suli,Sun, Dan,et al. Expression of 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase-2 in non-small cell lung cancer: Correlations with angiogenesis and prognosis[J]. ONCOLOGY LETTERS,2014,8(4):1589-1594.
APA Li, Ying,Li, Suli,Sun, Dan,Song, Linlin,&Liu, Xinmin.(2014).Expression of 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase-2 in non-small cell lung cancer: Correlations with angiogenesis and prognosis.ONCOLOGY LETTERS,8(4),1589-1594.
MLA Li, Ying,et al."Expression of 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase-2 in non-small cell lung cancer: Correlations with angiogenesis and prognosis".ONCOLOGY LETTERS 8.4(2014):1589-1594.
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