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学科主题: 临床医学
题名:
Antilymphocyte Antibodies in Systemic Lupus Erythematosus: Association with Disease Activity and Lymphopenia
作者: Li, Chun1; Mu, Rong1; Lu, Xiao-yan2; He, Jing1; Jia, Ru-lin1; Li, Zhan-guo1
刊名: JOURNAL OF IMMUNOLOGY RESEARCH
发表日期: 2014
DOI: 10.1155/2014/672126
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: LYMPHOCYTOTOXIC ANTIBODIES ; NEUROPSYCHIATRIC MANIFESTATIONS ; AUTOANTIBODIES ; EXPRESSION ; RISK ; SLE
英文摘要:

Purpose. We analyzed the prevalence, clinical correlation, and the functional significance of ALA in patients with systemic lupus erythematosus (SLE). Methods. ALA IgG was detected by indirect immunofluorescence in the serum of 130 SLE patients, 75 patients with various rheumatic diseases, and 45 healthy controls (HC). Results. The sensitivity and specificity of ALA IgG in SLE were 42.3% and 96.7%, respectively. ALA was observed in 55.6% (50/90) of patients with lymphopenia, which was significantly higher than in patients with normal lymphocytes (5/40, 12.5%; P<0.001). Patients with active SLE showed higher ALA positivity (60.9%) than those with inactive disease (24.2%; X-2=17.925; P<0.001). ALA correlated significantly with hypocomplementemia, anti-dsDNA antibodies, and higher SLEDAI scores. The incidences of ALA in SLE patients who were seronegative for anti-dsDNA, anti-Sm, or both antibodies were 32.9% (26/79), 41.0% (43/105), and 32.4% (22/68), respectively. The ALA-positive group also had higher incidences of neuropsychiatric SLE (NPSLE) and lupus nephritis (LN). Inmultivariate analyses, ALA was independently associated with lymphopenia, higher SLEDAI scores, and increased risk for LN. ALA titers significantly decreased as clinical disease was ameliorated following treatment. Conclusions. ALA occurred more frequently in patients with active SLE and was independently associated with lymphopenia, disease activity, and LN.

语种: 英语
所属项目编号: 2012CB517700 ; 81202297
项目资助者: National High Technology Research and Development Program of China (973 Program) ; National Natural Science Foundation
WOS记录号: WOS:000335049600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57409
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Rheumatol & Immunol, Shenzhen 518036, Peoples R China

Recommended Citation:
Li, Chun,Mu, Rong,Lu, Xiao-yan,et al. Antilymphocyte Antibodies in Systemic Lupus Erythematosus: Association with Disease Activity and Lymphopenia[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2014.
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