IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Antilymphocyte Antibodies in Systemic Lupus Erythematosus: Association with Disease Activity and Lymphopenia
Li, Chun1; Mu, Rong1; Lu, Xiao-yan2; He, Jing1; Jia, Ru-lin1; Li, Zhan-guo1
刊名JOURNAL OF IMMUNOLOGY RESEARCH
2014
DOI10.1155/2014/672126
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]LYMPHOCYTOTOXIC ANTIBODIES ; NEUROPSYCHIATRIC MANIFESTATIONS ; AUTOANTIBODIES ; EXPRESSION ; RISK ; SLE
英文摘要

Purpose. We analyzed the prevalence, clinical correlation, and the functional significance of ALA in patients with systemic lupus erythematosus (SLE). Methods. ALA IgG was detected by indirect immunofluorescence in the serum of 130 SLE patients, 75 patients with various rheumatic diseases, and 45 healthy controls (HC). Results. The sensitivity and specificity of ALA IgG in SLE were 42.3% and 96.7%, respectively. ALA was observed in 55.6% (50/90) of patients with lymphopenia, which was significantly higher than in patients with normal lymphocytes (5/40, 12.5%; P<0.001). Patients with active SLE showed higher ALA positivity (60.9%) than those with inactive disease (24.2%; X-2=17.925; P<0.001). ALA correlated significantly with hypocomplementemia, anti-dsDNA antibodies, and higher SLEDAI scores. The incidences of ALA in SLE patients who were seronegative for anti-dsDNA, anti-Sm, or both antibodies were 32.9% (26/79), 41.0% (43/105), and 32.4% (22/68), respectively. The ALA-positive group also had higher incidences of neuropsychiatric SLE (NPSLE) and lupus nephritis (LN). Inmultivariate analyses, ALA was independently associated with lymphopenia, higher SLEDAI scores, and increased risk for LN. ALA titers significantly decreased as clinical disease was ameliorated following treatment. Conclusions. ALA occurred more frequently in patients with active SLE and was independently associated with lymphopenia, disease activity, and LN.

语种英语
WOS记录号WOS:000335049600001
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57409
专题北京大学第二临床医学院
北京大学第二临床医学院_风湿免疫科
作者单位1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Rheumatol & Immunol, Shenzhen 518036, Peoples R China
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GB/T 7714
Li, Chun,Mu, Rong,Lu, Xiao-yan,et al. Antilymphocyte Antibodies in Systemic Lupus Erythematosus: Association with Disease Activity and Lymphopenia[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2014.
APA Li, Chun,Mu, Rong,Lu, Xiao-yan,He, Jing,Jia, Ru-lin,&Li, Zhan-guo.(2014).Antilymphocyte Antibodies in Systemic Lupus Erythematosus: Association with Disease Activity and Lymphopenia.JOURNAL OF IMMUNOLOGY RESEARCH.
MLA Li, Chun,et al."Antilymphocyte Antibodies in Systemic Lupus Erythematosus: Association with Disease Activity and Lymphopenia".JOURNAL OF IMMUNOLOGY RESEARCH (2014).
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