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Pulmonary Toxicity in Mice Exposed to Low and Medium Doses of Water-Soluble Multi-Walled Carbon Nanotubes
Wang, X.1; Zang, J. J.1; Wang, H.3,4; Nie, H.4; Wang, T. C.2; Deng, X. Y.3; Gu, Y. Q.5; Liu, Z. H.1; Jia, G.1
关键词Taurine Multi-walled Carbon Nanotubes (Tau-mwnts) Mouse Lungs Pulmonary Toxicity Inflammation Recovery Character
刊名JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
2010-12-01
DOI10.1166/jnn.2010.2688
10期:12页:8516-8526
收录类别SCI ; ISTP
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]RELEASE ; TISSUE
英文摘要

Carbon nanotubes (CNTs) are a class of new allotrope of carbon. Different functionalized CNTs may vary from their physical and chemical properties to the biological property. In this study, the toxicity of water-soluble taurine multi-walled CNTs (tau-MWNTs), raw MWNTs and positive control crystalline silicon dioxide particles on mouse lungs via intratracheal instillation (i.t.) was investigated. The dosages we used were 0.125, 0.25, 0.5 or 1 mg/kg of tau-MWNTs and raw MWNTs, and 1 mg/kg of silicon dioxide particles; Serum and lungs were collected at 1, 7, 14 or 28 days postexposure. The biochemical and cellular parameters were assessed, which include the ratio of the lung weight and body weight (lung indices), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and angiotensin converting enzyme (ACE) in serum, and malondialdehyde (MDA), reduced glutathione (GSH), total sulfhydryl group (TSH) in lung tissue homogenates as well as the hydroxyproline in lungs. The characteristic recovery of the lung injury at 28 days postexposure was examined by the assessment of LDH, ALP, lung indices, and histopathology. ACE, MDA, GSH, TSH and histopathological changes showed that tau-MWNTs were less toxic than the raw MWNTs. Histopathological and ultrastructural investigation indicated that the acute pulmonary inflammation in lungs alleviated after 7d postexposure, and were greatly recovered within 28d. Meanwhile, the entrapment of tau-MWNTs reduced greatly by the 28d postexposure. Whereas the heavier pathologic changes induced by raw MWNTs lasted 7 days more than that of tau-MWNTs. Notably, no occurrence of granulomas and fibrosis were found in this study both in the two CNTs samples through 28d postexposure. Silicon dioxide particles, on the contrary, produced more severe damage to lungs than CNTs did in lung index, as well as other biochemical and cellular parameters. These findings indicate that water-soluble tau-MWNTs in low and medium doses induce slight and recoverable pulmonary inflammation in mice, and are less toxic than the insoluble raw MWNTs.

语种英语
WOS记录号WOS:000283621400088
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57411
Collection北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Clin Lab, Beijing 100191, Peoples R China
3.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
4.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
5.Haidian Maternal & Child Hlth Hosp, Dept Pathol, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Wang, X.,Zang, J. J.,Wang, H.,et al. Pulmonary Toxicity in Mice Exposed to Low and Medium Doses of Water-Soluble Multi-Walled Carbon Nanotubes[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(12):8516-8526.
APA Wang, X..,Zang, J. J..,Wang, H..,Nie, H..,Wang, T. C..,...&Jia, G..(2010).Pulmonary Toxicity in Mice Exposed to Low and Medium Doses of Water-Soluble Multi-Walled Carbon Nanotubes.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(12),8516-8526.
MLA Wang, X.,et al."Pulmonary Toxicity in Mice Exposed to Low and Medium Doses of Water-Soluble Multi-Walled Carbon Nanotubes".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.12(2010):8516-8526.
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