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学科主题: 药学
题名:
Binary chromatographic fingerprint analysis of Stemonae Radix from three Stemona plants and its applications
作者: Fan, Lan-Lan1,2; Xu, Feng1; Hu, Jun-Ping1; Yang, Dong-Hui1; Chen, Hu-Biao3; Komatsu, Katsuko4; Zhu, Shu4; Shang, Ming-Ying1; Wang, Xuan1; Cai, Shao-Qing1,2
关键词: Stemonae Radix ; Binary chromatography ; Liquid chromatography-mass spectrometry (LC-MS) ; Similarity ; Medicinal parts ; Processing ; Stemona
刊名: JOURNAL OF NATURAL MEDICINES
发表日期: 2015-07-01
DOI: 10.1007/s11418-015-0887-7
卷: 69, 期:3, 页:402-410
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: MASS-SPECTROMETRY ; CHLOROGENIC ACIDS ; ALKALOIDS ; TUBEROSA ; CONSTITUENTS ; DERIVATIVES
英文摘要:

The dried root tubers of Stemona tuberosa, S. japonica and S. sessilifolia are the original sources of Stemonae Radix (SR) for antitussive and insecticidal activities. The products of SR which are available on the market are variable, and imitations exist. In order to characterize the overall chemical constituents of SR and evaluate its quality, a novel, binary high-performance liquid chromatographic fingerprinting method, describing the pattern of alkaloids (fingerprint I) and non-alkaloids (fingerprint II) of SR was developed. It was also applied to determine whether the medicinal parts and the processing methods affect the quality of SR. Similarity and high-performance liquid chromatography-mass spectrometry (HPLC-MSn) were utilized to compare or identify the chemical constituents of SR. The results indicate that the chemical constituents from different parts of the underground material of Stemona plants are diverse and that the processing methods affect certain constituents in the root tuber samples. The similarity and the resulting chemical consitituents obtained show that the binary chromatographic fingerprint method can be used to differentiate the three official Stemona species or the adulterants of SR, which is helpful for the identification and quality evaluation of SR.

语种: 英语
所属项目编号: 30425018 ; 31060055 ; Zhong2010111 ; Z2010175
项目资助者: National Science Fund of the People&prime ; s Republic of China ; Health Department of Guangxi province
WOS记录号: WOS:000355875800017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57412
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Guangxi Bot Garden Med Plants, Nanning 530023, Peoples R China
3.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China
4.Toyama Univ, Inst Nat Med, Dept Med Resources, Div Pharmacognosy, Toyama 9300194, Japan

Recommended Citation:
Fan, Lan-Lan,Xu, Feng,Hu, Jun-Ping,et al. Binary chromatographic fingerprint analysis of Stemonae Radix from three Stemona plants and its applications[J]. JOURNAL OF NATURAL MEDICINES,2015,69(3):402-410.
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