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Effect of statin therapy on cardiovascular and renal outcomes in patients with chronic kidney disease: a systematic review and meta-analysis
Hou, Wanyin1,2; Lv, Jicheng1,2; Perkovic, Vlado3; Yang, Lihong4; Zhao, Na1,2; Jardine, Meg J.3; Cass, Alan3; Zhang, Hong1,2; Wang, Haiyan1,2
关键词Cardiovascular Events Statin Chronic Kidney Disease Meta-analysis
刊名EUROPEAN HEART JOURNAL
2013-06-01
DOI10.1093/eurheartj/eht065
34期:24页:1807-+
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
资助者Major State Basic Research Development Program of China (973 program) ; National Natural Science Foundation of China ; Natural Science Fund of China to the Innovation Research Group ; Program for New Century Excellent Talents in University from the Ministry of Education of China ; Major State Basic Research Development Program of China (973 program) ; National Natural Science Foundation of China ; Natural Science Fund of China to the Innovation Research Group ; Program for New Century Excellent Talents in University from the Ministry of Education of China
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]C-REACTIVE PROTEIN ; PLACEBO-CONTROLLED TRIAL ; HEMODIALYSIS-PATIENTS ; RANDOMIZED-TRIALS ; DIALYSIS PATIENTS ; NATIONAL-HEALTH ; UNITED-STATES ; ALL-CAUSE ; ATORVASTATIN ; CHOLESTEROL
英文摘要

Aims The effects of statin therapy in patients with chronic kidney disease (CKD) remain uncertain. We undertook a systematic review and meta-analysis to investigate the effects of statin on major clinical outcomes.

Methods and results We systematically searched MEDLINE, Embase, and the Cochrane Library for trials published between 1970 and November 2011. We included prospective, randomized, controlled trials assessing the effects of statins on cardiovascular outcomes in people with kidney disease. Summary estimates of relative risk (RR) reductions were calculated with a random effects model. Thirty-one trials that include at least one event were identified, providing data for 48429 patients with CKD, including 6690 major cardiovascular events and 6653 deaths. Statin therapy produced a 23% RR reduction (16-30) for major cardiovascular events (P < 0.001), an 18% RR reduction (8-27) for coronary events, and 9% (1-16) reduction in cardiovascular or all-cause deaths, but had no significantly effect on stroke (21%, -12 to 44) or no clear effect on kidney failure events (5%, -1 to 10). Adverse events were not significantly increased by statins, including hepatic (RR 1.13, 95% CI 0.92-1.39) or muscular disorders (RR 1.02, 95% CI 0.95-1.09). Subgroup analysis demonstrated the relative effects of statin therapy in CKD were significantly reduced in people with advanced CKD (P < 0.001) but that the absolute risk reductions were comparable.

Conclusion Statin therapy reduces the risk of major cardiovascular events in patients with chronic kidney disease including those receiving dialysis.

语种英语
所属项目编号2012CB517700 ; 81270795 ; 30825021 ; 81021004 ; NCET-12-0011
资助者Major State Basic Research Development Program of China (973 program) ; National Natural Science Foundation of China ; Natural Science Fund of China to the Innovation Research Group ; Program for New Century Excellent Talents in University from the Ministry of Education of China ; Major State Basic Research Development Program of China (973 program) ; National Natural Science Foundation of China ; Natural Science Fund of China to the Innovation Research Group ; Program for New Century Excellent Talents in University from the Ministry of Education of China
WOS记录号WOS:000321054700014
引用统计
被引频次:83[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57417
专题北京大学第一临床医学院_肾脏内科
作者单位1.Guangdong Prov Hosp Chinese Med, Guangzhou, Guangdong, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Inst Nephrol, Peking Univ Hosp 1, Div Renal, Beijing 100871, Peoples R China
4.Univ Sydney, George Inst Global Hlth, Sydney, NSW 2006, Australia
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GB/T 7714
Hou, Wanyin,Lv, Jicheng,Perkovic, Vlado,et al. Effect of statin therapy on cardiovascular and renal outcomes in patients with chronic kidney disease: a systematic review and meta-analysis[J]. EUROPEAN HEART JOURNAL,2013,34(24):1807-+.
APA Hou, Wanyin.,Lv, Jicheng.,Perkovic, Vlado.,Yang, Lihong.,Zhao, Na.,...&Wang, Haiyan.(2013).Effect of statin therapy on cardiovascular and renal outcomes in patients with chronic kidney disease: a systematic review and meta-analysis.EUROPEAN HEART JOURNAL,34(24),1807-+.
MLA Hou, Wanyin,et al."Effect of statin therapy on cardiovascular and renal outcomes in patients with chronic kidney disease: a systematic review and meta-analysis".EUROPEAN HEART JOURNAL 34.24(2013):1807-+.
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