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学科主题: 临床医学
题名:
Effect of statin therapy on cardiovascular and renal outcomes in patients with chronic kidney disease: a systematic review and meta-analysis
作者: Hou, Wanyin1,2; Lv, Jicheng1,2; Perkovic, Vlado3; Yang, Lihong4; Zhao, Na1,2; Jardine, Meg J.3; Cass, Alan3; Zhang, Hong1,2; Wang, Haiyan1,2
关键词: Cardiovascular events ; Statin ; Chronic kidney disease ; Meta-analysis
刊名: EUROPEAN HEART JOURNAL
发表日期: 2013-06-01
DOI: 10.1093/eurheartj/eht065
卷: 34, 期:24, 页:1807-+
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: C-REACTIVE PROTEIN ; PLACEBO-CONTROLLED TRIAL ; HEMODIALYSIS-PATIENTS ; RANDOMIZED-TRIALS ; DIALYSIS PATIENTS ; NATIONAL-HEALTH ; UNITED-STATES ; ALL-CAUSE ; ATORVASTATIN ; CHOLESTEROL
英文摘要:

Aims The effects of statin therapy in patients with chronic kidney disease (CKD) remain uncertain. We undertook a systematic review and meta-analysis to investigate the effects of statin on major clinical outcomes.

Methods and results We systematically searched MEDLINE, Embase, and the Cochrane Library for trials published between 1970 and November 2011. We included prospective, randomized, controlled trials assessing the effects of statins on cardiovascular outcomes in people with kidney disease. Summary estimates of relative risk (RR) reductions were calculated with a random effects model. Thirty-one trials that include at least one event were identified, providing data for 48429 patients with CKD, including 6690 major cardiovascular events and 6653 deaths. Statin therapy produced a 23% RR reduction (16-30) for major cardiovascular events (P < 0.001), an 18% RR reduction (8-27) for coronary events, and 9% (1-16) reduction in cardiovascular or all-cause deaths, but had no significantly effect on stroke (21%, -12 to 44) or no clear effect on kidney failure events (5%, -1 to 10). Adverse events were not significantly increased by statins, including hepatic (RR 1.13, 95% CI 0.92-1.39) or muscular disorders (RR 1.02, 95% CI 0.95-1.09). Subgroup analysis demonstrated the relative effects of statin therapy in CKD were significantly reduced in people with advanced CKD (P < 0.001) but that the absolute risk reductions were comparable.

Conclusion Statin therapy reduces the risk of major cardiovascular events in patients with chronic kidney disease including those receiving dialysis.

语种: 英语
所属项目编号: 2012CB517700 ; 81270795 ; 30825021 ; 81021004 ; NCET-12-0011
项目资助者: Major State Basic Research Development Program of China (973 program) ; National Natural Science Foundation of China ; Natural Science Fund of China to the Innovation Research Group ; Program for New Century Excellent Talents in University from the Ministry of Education of China
WOS记录号: WOS:000321054700014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57417
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Guangdong Prov Hosp Chinese Med, Guangzhou, Guangdong, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Inst Nephrol, Peking Univ Hosp 1, Div Renal, Beijing 100871, Peoples R China
4.Univ Sydney, George Inst Global Hlth, Sydney, NSW 2006, Australia

Recommended Citation:
Hou, Wanyin,Lv, Jicheng,Perkovic, Vlado,et al. Effect of statin therapy on cardiovascular and renal outcomes in patients with chronic kidney disease: a systematic review and meta-analysis[J]. EUROPEAN HEART JOURNAL,2013,34(24):1807-+.
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