IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats
Yi, Ming1; Zhang, Haolin1; Lao, Lixing2; Xing, Guo-Gang1; Wan, You1,3
关键词pain acupuncture electroacupuncture anterior cingulate cortex formalin test
刊名MOLECULAR PAIN
2011-08-22
DOI10.1186/1744-8069-7-61
7期:Aug 22
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者China Postdoctoral Science Foundation ; Ministry of Science and Technology of China ; Ministry of Education of China ; Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Ministry of Science and Technology of China ; Ministry of Education of China ; Natural Science Foundation of China
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]ELECTRICAL-STIMULATION ; NOCICEPTIVE NEURONS ; NEUROPATHIC PAIN ; ACUPUNCTURE ; POTENTIATION ; FACILITATION ; MODULATION ; PLASTICITY ; RESPONSES ; BEHAVIOR
英文摘要

Acupuncture and electro-acupuncture (EA) are now widely used to treat disorders like pain. We and others have shown previously that current frequency, intensity and treatment duration all significantly influence the antinociceptive effects of EA. There is evidence that stimulating sites also affect the antinociception, with EA applied ipsilaterally to the pain site being more effective under some pain states but contralateral EA under others. It was recently reported that local adenosine A1 receptors were responsible for ipsilateral acupuncture, but what mechanisms specifically mediate the anti-nociceptive effects of contralateral acupuncture or EA remains unclear. In the present study, we applied 100 Hz EA on the ipsi- or contra-lateral side of rats with inflammatory pain induced by intra-plantar injection of formalin, and reported distinct anti-nociceptive effects and mechanisms between them. Both ipsi- and contra-lateral EA reduced the paw lifting time in the second phase of the formalin test and attenuated formalin-induced conditioned place aversion. Contralateral EA had an additional effect of reducing paw licking time, suggesting a supraspinal mechanism. Lesions of rostral anterior cingulate cortex (ACC) completely abolished the anti-nociceptive effects of contra-but not ipsi-lateral EA. These findings were not lateralized effects, since injection of formalin into the left or right hind paws produced similar results. Overall, these results demonstrated distinct anti-nociceptive effects and mechanisms between different stimulating sides and implied the necessity of finding the best stimulating protocols for different pain states.

语种英语
所属项目编号20090460180 ; 2007CB512501 ; 81070893
资助者China Postdoctoral Science Foundation ; Ministry of Science and Technology of China ; Ministry of Education of China ; Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Ministry of Science and Technology of China ; Ministry of Education of China ; Natural Science Foundation of China
WOS记录号WOS:000294851800001
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57420
Collection北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Univ Maryland, Sch Med, Ctr Integrat Med, Baltimore, MD 21201 USA
3.Minist Publ Hlth, Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Yi, Ming,Zhang, Haolin,Lao, Lixing,et al. Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats[J]. MOLECULAR PAIN,2011,7(Aug 22).
APA Yi, Ming,Zhang, Haolin,Lao, Lixing,Xing, Guo-Gang,&Wan, You.(2011).Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats.MOLECULAR PAIN,7(Aug 22).
MLA Yi, Ming,et al."Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats".MOLECULAR PAIN 7.Aug 22(2011).
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