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学科主题: 临床医学
题名:
Guidelines for Therapeutic Drug Monitoring of Vancomycin: A Systematic Review
作者: Ye, Zhi-Kang1,2; Li, Can1,2; Zhai, Suo-Di1
刊名: PLOS ONE
发表日期: 2014-06-16
DOI: 10.1371/journal.pone.0099044
卷: 9, 期:6
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: SERUM CONCENTRATIONS ; INFECTIONS ; CONSENSUS ; QUALITY ; NEED
英文摘要:

Background and Objective: Despite the availability of clinical practice guidelines (CPGs) for therapeutic drug monitoring (TDM) of vancomycin, vancomycin serum concentrations still do not reach therapeutic concentrations in many patients. Thus, we sought to systematically review the quality and consistency of recommendations for an international cohort of CPGs regarding vancomycin TDM.

Methods: PubMed, Embase, guidelines′ websites and Google were searched for CPGs for vancomycin TDM. Two independent assessors rated the quality of each CPG using the Appraisal of Guidelines for Research & Evaluation II (AGREEII) instrument and data were independently extracted.

Results: Twelve guidelines were evaluated and the overall quality of guidelines for vancomycin TDM was moderate. The highest score was recorded in the domain of clarity of presentation, and the lowest score was recorded in the domain of rigor of development and stakeholder involvement. The specific recommendations for vancomycin TDM were moderately consistent and guidelines varied in trough concentration monitoring, frequency of TDM, and serum concentration targets.

Conclusion: The overall guideline quality for vancomycin TDM was not optimal and effort is needed to improve guideline quality, especially in the domain of rigor of development and stakeholder involvement.

语种: 英语
WOS记录号: WOS:000337738600019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57422
Appears in Collections:北京大学第三临床医学院_药剂科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Pharm, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Pharm Adm & Clin Pharm, Beijing 100871, Peoples R China

Recommended Citation:
Ye, Zhi-Kang,Li, Can,Zhai, Suo-Di. Guidelines for Therapeutic Drug Monitoring of Vancomycin: A Systematic Review[J]. PLOS ONE,2014,9(6).
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