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Guidelines for Therapeutic Drug Monitoring of Vancomycin: A Systematic Review
Ye, Zhi-Kang1,2; Li, Can1,2; Zhai, Suo-Di1
刊名PLOS ONE
2014-06-16
DOI10.1371/journal.pone.0099044
9期:6
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]SERUM CONCENTRATIONS ; INFECTIONS ; CONSENSUS ; QUALITY ; NEED
英文摘要

Background and Objective: Despite the availability of clinical practice guidelines (CPGs) for therapeutic drug monitoring (TDM) of vancomycin, vancomycin serum concentrations still do not reach therapeutic concentrations in many patients. Thus, we sought to systematically review the quality and consistency of recommendations for an international cohort of CPGs regarding vancomycin TDM.

Methods: PubMed, Embase, guidelines′ websites and Google were searched for CPGs for vancomycin TDM. Two independent assessors rated the quality of each CPG using the Appraisal of Guidelines for Research & Evaluation II (AGREEII) instrument and data were independently extracted.

Results: Twelve guidelines were evaluated and the overall quality of guidelines for vancomycin TDM was moderate. The highest score was recorded in the domain of clarity of presentation, and the lowest score was recorded in the domain of rigor of development and stakeholder involvement. The specific recommendations for vancomycin TDM were moderately consistent and guidelines varied in trough concentration monitoring, frequency of TDM, and serum concentration targets.

Conclusion: The overall guideline quality for vancomycin TDM was not optimal and effort is needed to improve guideline quality, especially in the domain of rigor of development and stakeholder involvement.

语种英语
WOS记录号WOS:000337738600019
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57422
专题北京大学第三临床医学院_药剂科
作者单位1.Peking Univ, Hosp 3, Dept Pharm, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Pharm Adm & Clin Pharm, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Ye, Zhi-Kang,Li, Can,Zhai, Suo-Di. Guidelines for Therapeutic Drug Monitoring of Vancomycin: A Systematic Review[J]. PLOS ONE,2014,9(6).
APA Ye, Zhi-Kang,Li, Can,&Zhai, Suo-Di.(2014).Guidelines for Therapeutic Drug Monitoring of Vancomycin: A Systematic Review.PLOS ONE,9(6).
MLA Ye, Zhi-Kang,et al."Guidelines for Therapeutic Drug Monitoring of Vancomycin: A Systematic Review".PLOS ONE 9.6(2014).
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