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学科主题: 临床医学
题名:
Human serum acylcarnitine profiles in different glucose tolerance states
作者: Zhang, Xiuying1; Zhang, Chunfang2; Chen, Ling1; Han, Xueyao1; Ji, Linong1
关键词: Type 2 diabetes ; Pre-diabetes ; Carnitine ; Metabolism ; Mass spectrometry
刊名: DIABETES RESEARCH AND CLINICAL PRACTICE
发表日期: 2014-06-01
DOI: 10.1016/j.diabres.2014.04.013
卷: 104, 期:3, 页:376-382
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: DIABETES-MELLITUS ; INSULIN-RESISTANCE ; SKELETAL-MUSCLE ; CARNITINE DEFICIENCY ; CARDIOVASCULAR EVENTS ; LIPID-METABOLISM ; COMPLICATIONS ; WOMEN ; ASSOCIATION ; HOMEOSTASIS
英文摘要:

Aims: To understand the relationship between serum acylcarnitine profiles and glucose tolerance status.

Methods: We analyzed 61 subjects who were divided into three groups based on their glucose tolerance status: normal glucose tolerance (NGT; n = 20, M/F = 9/11, mean age 48 years), prediabetes (Pre-DM; n = 20, M/F = 11/9, mean age 51 years), or newly diagnosed type 2 diabetes mellitus (T2DM; n = 21, M/F = 8/13, mean age 49 years). Fasting serum free carnitine and acylcarnitine concentrations were determined using isotope dilution electrospray ionization mass spectrometry coupled with high performance liquid chromatography.

Results: In comparison with NGT subjects, Pre-DM and type 2 diabetes subjects showed serum metabonomic changes highlighted by dysregulation of mitochondrial fatty acid combustion. Of the long-chain carnitine esters, significantly higher palmitoylcarnitine (C16), 3-OH-hexadecanoylcarnitine (C16-OH), carnitine C20, carnitine C22, and carnitine C24 concentrations (all P < 0.05) were noted in the newly diagnosed type 2 diabetes group, and even the pre-diabetes group.

Conclusions: This research provides further evidence of alterations in serum acylcarnitine profiles being associated with worse glucoseintolerance. The findings may suggest different degrees of involvement of dysregulated mitochondrial function and incomplete long-chain fatty acid oxidation pathways in the natural course of type 2 diabetes. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2006AA02A409
项目资助者: National High Technology Research and Development Program
WOS记录号: WOS:000338715200016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57429
Appears in Collections:北京大学第二临床医学院_内分泌科_期刊论文

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作者单位: 1.Peking Univ, Ctr Diabet, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Clin Epidemiol, Beijing 100044, Peoples R China

Recommended Citation:
Zhang, Xiuying,Zhang, Chunfang,Chen, Ling,et al. Human serum acylcarnitine profiles in different glucose tolerance states[J]. DIABETES RESEARCH AND CLINICAL PRACTICE,2014,104(3):376-382.
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