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学科主题: 医学信息学
题名:
Maternal and cord blood hormones in relation to birth size
作者: Lagiou, Pagona1,2; Samoli, Evangelia2; Hsieh, Chung-Cheng1,3; Lagiou, Areti4; Xu, Bio5; Yu, Guo-Pei6; Onoyama, Sagano3; Chie, Lucy7; Adami, Hans-Olov1,8; Vatten, Lars J.9; Trichopoulos, Dimitrios1; Williams, Michelle A.1
关键词: Birth weight ; Birth length ; Insulin like growth factor ; Estriol ; Progesterone ; Pregnancy ; Maternal height ; Cord blood
刊名: EUROPEAN JOURNAL OF EPIDEMIOLOGY
发表日期: 2014-05-01
DOI: 10.1007/s10654-014-9914-3
卷: 29, 期:5, 页:343-351
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Public, Environmental & Occupational Health
研究领域[WOS]: Public, Environmental & Occupational Health
关键词[WOS]: BREAST-CANCER RISK ; GROWTH-FACTOR-I ; PREGNANCY ESTRIOL ; UNITED-STATES ; WEIGHT ; INSULIN ; CHINA ; PROGESTERONE ; TERM ; USA
英文摘要:

Birth size has been associated with adult life diseases, but the endocrine factors that are likely involved are not established. We evaluated the associations of maternal and cord blood hormones with birth size in normal pregnancies, and examined possible effect modification by maternal height, on the basis of prior suggestive evidence. In a prospective study of normal singleton pregnancies in Boston, USA and Shanghai, China, maternal hormone levels at the 27th gestational week were available for 225 pregnancies in Boston and 281 in Shanghai and cord blood measurements for 92 pregnancies in Boston and 110 in Shanghai. Pearson partial correlation coefficients of log-transformed hormone levels with birth weight and length were calculated. Overall, positive correlations with birth weight were found for maternal estriol (r = 0.19; p < 0.001) and progesterone (r = 0.15; p < 0.001) and these associations were more evident among taller mothers. There was an inverse association of cord blood progesterone (r = -0.16; p < 0.03) with birth weight. In Boston, cord blood IGF-1 was positively associated with birth weight (r = 0.22; p < 0.04) and length (r = 0.25; p < 0.02), particularly among taller mothers (r = 0.43 and 0.38, respectively; p < 0.02), whereas among taller mothers in Shanghai the associations of IGF-2 with birth size appeared to be at least as strong as those of IGF-1. In conclusion, maternal estriol and progesterone, and cord blood IGF-1 were positively correlated with birth size. All correlations tended to be more pronounced among offspring of taller mothers. Among taller mothers in Shanghai, IGF-2 appeared to be at least as strongly associated with birth size as IGF-1.

语种: 英语
所属项目编号: CA54220 ; W81XWH-05-1-0314
项目资助者: National Cancer Institute/National Institutes of Health ; US Department of Defence Breast Cancer Research Program, Office of the Congressionally Directed Medical Research Programs
WOS记录号: WOS:000337148200005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57430
Appears in Collections:北京大学医学信息学中心_期刊论文

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作者单位: 1.Peking Univ, Med Informat Ctr, Beijing 100871, Peoples R China
2.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
3.Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece
4.Univ Massachusetts, Sch Med, Dept Canc Biol, Worcester, MA USA
5.Athens Technol Educ Inst, Fac Hlth Profess, Dept Publ Hlth & Community Hlth, Athens, Greece
6.Fudan Univ, Sch Publ Hlth, Dept Epidemiol, Shanghai 200433, Peoples R China
7.Beth Israel Deaconess Med Ctr, Dept Obstet & Gynecol, Boston, MA 02215 USA
8.Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
9.Norwegian Univ Sci & Technol, Sch Med, Dept Community Med & Gen Practice, N-7034 Trondheim, Norway

Recommended Citation:
Lagiou, Pagona,Samoli, Evangelia,Hsieh, Chung-Cheng,et al. Maternal and cord blood hormones in relation to birth size[J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY,2014,29(5):343-351.
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