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Maternal and cord blood hormones in relation to birth size
Lagiou, Pagona1,2; Samoli, Evangelia2; Hsieh, Chung-Cheng1,3; Lagiou, Areti4; Xu, Bio5; Yu, Guo-Pei6; Onoyama, Sagano3; Chie, Lucy7; Adami, Hans-Olov1,8; Vatten, Lars J.9; Trichopoulos, Dimitrios1; Williams, Michelle A.1
关键词Birth Weight Birth Length Insulin Like Growth Factor Estriol Progesterone Pregnancy Maternal Height Cord Blood
刊名EUROPEAN JOURNAL OF EPIDEMIOLOGY
2014-05-01
DOI10.1007/s10654-014-9914-3
29期:5页:343-351
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
研究领域[WOS]Public, Environmental & Occupational Health
关键词[WOS]BREAST-CANCER RISK ; GROWTH-FACTOR-I ; PREGNANCY ESTRIOL ; UNITED-STATES ; WEIGHT ; INSULIN ; CHINA ; PROGESTERONE ; TERM ; USA
英文摘要

Birth size has been associated with adult life diseases, but the endocrine factors that are likely involved are not established. We evaluated the associations of maternal and cord blood hormones with birth size in normal pregnancies, and examined possible effect modification by maternal height, on the basis of prior suggestive evidence. In a prospective study of normal singleton pregnancies in Boston, USA and Shanghai, China, maternal hormone levels at the 27th gestational week were available for 225 pregnancies in Boston and 281 in Shanghai and cord blood measurements for 92 pregnancies in Boston and 110 in Shanghai. Pearson partial correlation coefficients of log-transformed hormone levels with birth weight and length were calculated. Overall, positive correlations with birth weight were found for maternal estriol (r = 0.19; p < 0.001) and progesterone (r = 0.15; p < 0.001) and these associations were more evident among taller mothers. There was an inverse association of cord blood progesterone (r = -0.16; p < 0.03) with birth weight. In Boston, cord blood IGF-1 was positively associated with birth weight (r = 0.22; p < 0.04) and length (r = 0.25; p < 0.02), particularly among taller mothers (r = 0.43 and 0.38, respectively; p < 0.02), whereas among taller mothers in Shanghai the associations of IGF-2 with birth size appeared to be at least as strong as those of IGF-1. In conclusion, maternal estriol and progesterone, and cord blood IGF-1 were positively correlated with birth size. All correlations tended to be more pronounced among offspring of taller mothers. Among taller mothers in Shanghai, IGF-2 appeared to be at least as strongly associated with birth size as IGF-1.

语种英语
WOS记录号WOS:000337148200005
项目编号CA54220 ; W81XWH-05-1-0314
资助机构National Cancer Institute/National Institutes of Health ; US Department of Defence Breast Cancer Research Program, Office of the Congressionally Directed Medical Research Programs
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57430
专题北京大学医学信息学中心
作者单位1.Peking Univ, Med Informat Ctr, Beijing 100871, Peoples R China
2.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
3.Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece
4.Univ Massachusetts, Sch Med, Dept Canc Biol, Worcester, MA USA
5.Athens Technol Educ Inst, Fac Hlth Profess, Dept Publ Hlth & Community Hlth, Athens, Greece
6.Fudan Univ, Sch Publ Hlth, Dept Epidemiol, Shanghai 200433, Peoples R China
7.Beth Israel Deaconess Med Ctr, Dept Obstet & Gynecol, Boston, MA 02215 USA
8.Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
9.Norwegian Univ Sci & Technol, Sch Med, Dept Community Med & Gen Practice, N-7034 Trondheim, Norway
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GB/T 7714
Lagiou, Pagona,Samoli, Evangelia,Hsieh, Chung-Cheng,et al. Maternal and cord blood hormones in relation to birth size[J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY,2014,29(5):343-351.
APA Lagiou, Pagona.,Samoli, Evangelia.,Hsieh, Chung-Cheng.,Lagiou, Areti.,Xu, Bio.,...&Williams, Michelle A..(2014).Maternal and cord blood hormones in relation to birth size.EUROPEAN JOURNAL OF EPIDEMIOLOGY,29(5),343-351.
MLA Lagiou, Pagona,et al."Maternal and cord blood hormones in relation to birth size".EUROPEAN JOURNAL OF EPIDEMIOLOGY 29.5(2014):343-351.
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