IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Characteristics of electroacupuncture-induced analgesia in mice: variation with strain, frequency, intensity and opioid involvement
Huang, C; Wang, Y; Han, JS; Wan, Y
关键词analgesia electroacupuncture strain morphine naloxone
刊名BRAIN RESEARCH
2002-07-26
945期:1页:20-25
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MORPHINE ; RAT
英文摘要

The present study was conducted to evaluate the characteristics of electroacupuncture (EA)-induced analgesia in mice. Three inbred strains of mice (DBA/2, C57BL/6J, BALB/c) and three outbred strains (ICR, LACA, NIH) were used in the experiment. Two pairs of metallic needles were inserted into acupoints ST 36 and SP 6 connected to an electric pulse generator. EA parameters were set as constant current output with alteration of a positive and negative square wave, 0.6 ms in pulse width for 2 Hz and 0.3 ms for 100 Hz. Tail-flick latencies evoked by radiant heat were measured before, during and after EA stimulation. We found that (1) DBA/2 mice showed a significantly more potent analgesic effect than the other five strains in response to both 100 and 2 Hz EA. In this case, the intensities were 1.0-2.0-2.0 mA, 10 min for each intensity totally 30 min. (2) EA analgesia increased as the intensity of stimulation increased from 0.5 to 2.0 mA, but it remained at this plateau when the intensity further increased from 2.0 to 3.0 mA. (3) 10.0 mg(.)kg(-1) naloxone was needed to block the analgesic effect induced by 2 Hz EA of 2.0 mA, but to block that by 100 Hz, 25.0 mg(.)kg(-1) was necessary. (4) A positive correlation was observed between analgesia induced by morphine at the dose of 5.0 mg(.)kg(-1) and by 100 Hz EA in two tested strains DBA/2 and C57BL/6J. In conclusion, EA induces reliable, strain-dependent analgesia in mice. The naloxone-reversibility of EA, a measure of whether it is opioid or non-opioid mediated, is dependent upon intensity and frequency. (C) 2002 Elsevier Science B.V. All rights reserved.

语种英语
WOS记录号WOS:000177224300003
引用统计
被引频次:65[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57438
专题北京大学基础医学院_神经生物学系
作者单位Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Huang, C,Wang, Y,Han, JS,et al. Characteristics of electroacupuncture-induced analgesia in mice: variation with strain, frequency, intensity and opioid involvement[J]. BRAIN RESEARCH,2002,945(1):20-25.
APA Huang, C,Wang, Y,Han, JS,&Wan, Y.(2002).Characteristics of electroacupuncture-induced analgesia in mice: variation with strain, frequency, intensity and opioid involvement.BRAIN RESEARCH,945(1),20-25.
MLA Huang, C,et al."Characteristics of electroacupuncture-induced analgesia in mice: variation with strain, frequency, intensity and opioid involvement".BRAIN RESEARCH 945.1(2002):20-25.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Characteristics of e(412KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Huang, C]的文章
[Wang, Y]的文章
[Han, JS]的文章
百度学术
百度学术中相似的文章
[Huang, C]的文章
[Wang, Y]的文章
[Han, JS]的文章
必应学术
必应学术中相似的文章
[Huang, C]的文章
[Wang, Y]的文章
[Han, JS]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Characteristics of electroacupuncture-induced analgesia in mice variation with strain, frequency, intensity and opioid involvement.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。