IR@PKUHSC  > 北京大学第二临床医学院  > 血液科
学科主题临床医学
Examination of copy number variations of CHST9 in multiple types of hematologic malignancies
Zhao, Xiaosu2; Wu, Qi3; Fu, Xinrong1; Yu, Bo3; Shao, Yong3; Yang, Hong4; Guan, Ming5; Huang, Xiaojun2; Zhang, Wei1,6; Wan, Jun1,3
刊名CANCER GENETICS AND CYTOGENETICS
2010-12-01
DOI10.1016/j.cancergencyto.2010.07.132
203期:2页:176-179
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Genetics & Heredity
研究领域[WOS]Oncology ; Genetics & Heredity
关键词[WOS]ACUTE LYMPHOBLASTIC-LEUKEMIA ; GENOMIC ALTERATIONS ; GENE ; ASSOCIATION ; EXPRESSION ; DELETION
英文摘要

Carbohydrate N-acetylgalactosamine 4-0 sulfotransferase 9 (CHST9) belongs to the N-acetylgalactosamine 4-sulfotransferase (GalNAc4ST) family. A recent array-based study implicated the presence of copy-number variations (CNV) of the region encompassing CHST9 in the genomes of acute myelogenous leukemia. Most of the current studies, however, focused on the genome-wide screening of CNV, and the functional impact of such regions needs to be extensively investigated in large amounts of clinical samples. In our study, we collected 617 bone marrow samples from multi-types of hematologic malignancies, as well as healthy controls, and detected the CNV of CHST9 by real-time polymerase chain reaction (PCR). We found significant association between the CNV of CHST9 and these hematologic malignancies including acute lymphoblastic leukemia, acute myelogenous leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia, multiple myeloma, and myelodysplastic syndrome. We also examined CHST9 mRNA expression in the samples with one or two copies of DNA, and observed a weak yet positive correlation between the relative expression level and gene dosage. In general, the CNV of CHST9 have been shown to associate with hematologic malignancies. The functional consequences of CNV, however, need to be investigated extensively in the future. (C) 2010 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000285866100009
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57444
专题北京大学第二临床医学院_血液科
北京大学临床肿瘤学院_护理部
作者单位1.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Inst Hematol, Peking Univ Peoples Hosp, Dept Hematol, Beijing 100044, Peoples R China
3.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Mol Diag & Translat Med, Shenzhen 518036, Guangdong, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen 518036, Guangdong, Peoples R China
5.Fudan Univ, Huashan Hosp, Cent Lab, Dept Lab Med, Shanghai 200040, Peoples R China
6.Ji Nan Univ, JNU HKUST Joint Lab Neurosci & Innovat Drug Res, Guangzhou 510632, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Xiaosu,Wu, Qi,Fu, Xinrong,et al. Examination of copy number variations of CHST9 in multiple types of hematologic malignancies[J]. CANCER GENETICS AND CYTOGENETICS,2010,203(2):176-179.
APA Zhao, Xiaosu.,Wu, Qi.,Fu, Xinrong.,Yu, Bo.,Shao, Yong.,...&Wan, Jun.(2010).Examination of copy number variations of CHST9 in multiple types of hematologic malignancies.CANCER GENETICS AND CYTOGENETICS,203(2),176-179.
MLA Zhao, Xiaosu,et al."Examination of copy number variations of CHST9 in multiple types of hematologic malignancies".CANCER GENETICS AND CYTOGENETICS 203.2(2010):176-179.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhao, Xiaosu]的文章
[Wu, Qi]的文章
[Fu, Xinrong]的文章
百度学术
百度学术中相似的文章
[Zhao, Xiaosu]的文章
[Wu, Qi]的文章
[Fu, Xinrong]的文章
必应学术
必应学术中相似的文章
[Zhao, Xiaosu]的文章
[Wu, Qi]的文章
[Fu, Xinrong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。