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学科主题: 临床医学
题名:
Examination of copy number variations of CHST9 in multiple types of hematologic malignancies
作者: Zhao, Xiaosu2; Wu, Qi3; Fu, Xinrong1; Yu, Bo3; Shao, Yong3; Yang, Hong4; Guan, Ming5; Huang, Xiaojun2; Zhang, Wei1,6; Wan, Jun1,3
刊名: CANCER GENETICS AND CYTOGENETICS
发表日期: 2010-12-01
DOI: 10.1016/j.cancergencyto.2010.07.132
卷: 203, 期:2, 页:176-179
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Genetics & Heredity
研究领域[WOS]: Oncology ; Genetics & Heredity
关键词[WOS]: ACUTE LYMPHOBLASTIC-LEUKEMIA ; GENOMIC ALTERATIONS ; GENE ; ASSOCIATION ; EXPRESSION ; DELETION
英文摘要:

Carbohydrate N-acetylgalactosamine 4-0 sulfotransferase 9 (CHST9) belongs to the N-acetylgalactosamine 4-sulfotransferase (GalNAc4ST) family. A recent array-based study implicated the presence of copy-number variations (CNV) of the region encompassing CHST9 in the genomes of acute myelogenous leukemia. Most of the current studies, however, focused on the genome-wide screening of CNV, and the functional impact of such regions needs to be extensively investigated in large amounts of clinical samples. In our study, we collected 617 bone marrow samples from multi-types of hematologic malignancies, as well as healthy controls, and detected the CNV of CHST9 by real-time polymerase chain reaction (PCR). We found significant association between the CNV of CHST9 and these hematologic malignancies including acute lymphoblastic leukemia, acute myelogenous leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia, multiple myeloma, and myelodysplastic syndrome. We also examined CHST9 mRNA expression in the samples with one or two copies of DNA, and observed a weak yet positive correlation between the relative expression level and gene dosage. In general, the CNV of CHST9 have been shown to associate with hematologic malignancies. The functional consequences of CNV, however, need to be investigated extensively in the future. (C) 2010 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000285866100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57444
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Inst Hematol, Peking Univ Peoples Hosp, Dept Hematol, Beijing 100044, Peoples R China
3.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Mol Diag & Translat Med, Shenzhen 518036, Guangdong, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen 518036, Guangdong, Peoples R China
5.Fudan Univ, Huashan Hosp, Cent Lab, Dept Lab Med, Shanghai 200040, Peoples R China
6.Ji Nan Univ, JNU HKUST Joint Lab Neurosci & Innovat Drug Res, Guangzhou 510632, Guangdong, Peoples R China

Recommended Citation:
Zhao, Xiaosu,Wu, Qi,Fu, Xinrong,et al. Examination of copy number variations of CHST9 in multiple types of hematologic malignancies[J]. CANCER GENETICS AND CYTOGENETICS,2010,203(2):176-179.
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