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学科主题: 临床医学
题名:
Downregulation of SPARC expression decreases gastric cancer cellular invasion and survival
作者: Yin, Jie; Chen, Guowei; Liu, Yucun; Liu, Si; Wang, Pengyuan; Wan, Yuanlian; Wang, Xin; Zhu, Jing; Gao, Hongqiao
刊名: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
发表日期: 2010-06-02
DOI: 10.1186/1756-9966-29-59
卷: 29
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CYSTEINE SPARC ; DIFFERENTIAL EXPRESSION ; NEOPLASTIC PROGRESSION ; MATRICELLULAR PROTEIN ; EXTRACELLULAR-MATRIX ; BASEMENT-MEMBRANE ; OVARIAN-CANCER ; HUMAN-MELANOMA ; CELLS ; TUMOR
英文摘要:

Background: Secreted protein acidic and rich in cysteine (SPARC) plays a key role in the development of many tissues and organ types. Aberrant SPARC expression was found in a wide variety of human cancers, contributes to tumor development. Because SPARC was found to be overexpressed in human gastric cancer tissue, we therefore to explore the expression of SPARC in gastric cancer lines and the carcinogenic mechanisms.

Methods: SPARC expression was evaluated in a panel of human gastric cancer cell lines. MGC803 and HGC 27 gastric cancer cell lines expressing high level of SPARC were transiently transfected with SPARC-specific small interfering RNAs and subsequently evaluated for effects on invasion and proliferation.

Results: Small interfering RNA-mediated knockdown of SPARC in MGC803 and HGC 27 gastric cancer cells dramatically decreased their invasion. Knockdown of SPARC was also observed to significantly increase the apoptosis of MGC803 and HGC 27 gastric cancer cells compared with control transfected group.

Conclusions: Our data showed that downregulating of SPARC inhibits invasion and growth of human gastric cancer cells. Thus, targeting of SPARC could be an effective therapeutic approach against gastric cancer.

语种: 英语
所属项目编号: 30901417
项目资助者: National Scientific Technologic Supporting Project Fund
WOS记录号: WOS:000279244600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57445
Appears in Collections:北京大学第一临床医学院_普通外科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Gen Surg, Beijing 100034, Peoples R China

Recommended Citation:
Yin, Jie,Chen, Guowei,Liu, Yucun,et al. Downregulation of SPARC expression decreases gastric cancer cellular invasion and survival[J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,2010,29.
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