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Downregulation of SPARC expression decreases gastric cancer cellular invasion and survival
Yin, Jie; Chen, Guowei; Liu, Yucun; Liu, Si; Wang, Pengyuan; Wan, Yuanlian; Wang, Xin; Zhu, Jing; Gao, Hongqiao
刊名JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
2010-06-02
DOI10.1186/1756-9966-29-59
29
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CYSTEINE SPARC ; DIFFERENTIAL EXPRESSION ; NEOPLASTIC PROGRESSION ; MATRICELLULAR PROTEIN ; EXTRACELLULAR-MATRIX ; BASEMENT-MEMBRANE ; OVARIAN-CANCER ; HUMAN-MELANOMA ; CELLS ; TUMOR
英文摘要

Background: Secreted protein acidic and rich in cysteine (SPARC) plays a key role in the development of many tissues and organ types. Aberrant SPARC expression was found in a wide variety of human cancers, contributes to tumor development. Because SPARC was found to be overexpressed in human gastric cancer tissue, we therefore to explore the expression of SPARC in gastric cancer lines and the carcinogenic mechanisms.

Methods: SPARC expression was evaluated in a panel of human gastric cancer cell lines. MGC803 and HGC 27 gastric cancer cell lines expressing high level of SPARC were transiently transfected with SPARC-specific small interfering RNAs and subsequently evaluated for effects on invasion and proliferation.

Results: Small interfering RNA-mediated knockdown of SPARC in MGC803 and HGC 27 gastric cancer cells dramatically decreased their invasion. Knockdown of SPARC was also observed to significantly increase the apoptosis of MGC803 and HGC 27 gastric cancer cells compared with control transfected group.

Conclusions: Our data showed that downregulating of SPARC inhibits invasion and growth of human gastric cancer cells. Thus, targeting of SPARC could be an effective therapeutic approach against gastric cancer.

语种英语
WOS记录号WOS:000279244600001
项目编号30901417
资助机构National Scientific Technologic Supporting Project Fund
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57445
专题北京大学第一临床医学院_普通外科
作者单位Peking Univ, Hosp 1, Dept Gen Surg, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Yin, Jie,Chen, Guowei,Liu, Yucun,et al. Downregulation of SPARC expression decreases gastric cancer cellular invasion and survival[J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,2010,29.
APA Yin, Jie.,Chen, Guowei.,Liu, Yucun.,Liu, Si.,Wang, Pengyuan.,...&Gao, Hongqiao.(2010).Downregulation of SPARC expression decreases gastric cancer cellular invasion and survival.JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,29.
MLA Yin, Jie,et al."Downregulation of SPARC expression decreases gastric cancer cellular invasion and survival".JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 29(2010).
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