IR@PKUHSC  > 北京大学第一临床医学院  > 儿科
学科主题临床医学
Plasma C-Type Natriuretic Peptide as a Predictor for Therapeutic Response to Metoprolol in Children with Postural Tachycardia Syndrome
Lin, Jing1; Han, Zhenhui2; Li, Hongxia1; Chen, Selena Ying3; Li, Xueying4; Liu, Ping1; Wang, Yuli1; Tang, Chaoshu5,6; Du, Junbao1; Jin, Hongfang1
刊名PLOS ONE
2015-03-26
DOI10.1371/journal.pone.0121913
10期:3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]NEURALLY-MEDIATED SYNCOPE ; CHRONIC HEART-FAILURE ; MIDODRINE HYDROCHLORIDE ; ORTHOSTATIC INTOLERANCE ; DIAGNOSTIC MANAGEMENT ; INCREASE ; CNP ; ADOLESCENTS ; RECEPTORS ; BIOMARKER
英文摘要

POTS is a global public-health disease, but predictor for therapeutic response to metoprolol in children with POTS is lacking. This study was designed to investigate predictive value of plasma C-type natriuretic peptide (CNP) in the therapeutic efficacy of metoprolol on postural tachycardia syndrome (POTS) in children. Totally 34 children with POTS and 27 healthy children were included in the study. The head-up test or head-up tilt test was used to check heart rate and blood pressure from supine to upright in subjects. A double antibody (competitive) sandwich immunoluminometric assay was used to detect plasma CNP. Metoprolol was used to treat children with POTS. The difference in plasma concentrations of CNP between responders and non-responders was compared. An ROC curve was used to analyze plasma CNP to predict efficacy of metoprolol on POTS in children. Plasma CNP in children with POTS was significantly higher than that of healthy children [(51.9 +/- 31.4) vs. (25.1 +/- 19.1) pg/ml, P < 0.001]. Plasma CNP in responders to metoprolol was significantly higher than non-responders [(59.1 +/- 33.5) vs. (34.8 +/- 16.7) pg/ml, P = 0.037] before treatment. The ROC curve showed that area under the curve was 0.821 (95% CI 0.642-0.999). The cut-off value of plasma CNP > 32.55 pg/ml yielded a sensitivity of 95.8% and specificity of 70% in predicting therapeutic efficacy of metoprolol on POTS children. Plasma CNP might serve as a useful predictor for the therapeutic efficacy of metoprolol on POTS in children.

语种英语
WOS记录号WOS:000356353700157
项目编号2012BAI03B03 ; 2012CB517806
资助机构National Twelfth Five-Year Plan for Science &amp ; Technology Support ; Major Basic Research Project
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57449
专题北京大学第一临床医学院_儿科
作者单位1.Kaifeng Childrens Hosp, Dept Pediat, Kaifeng, Henan, Peoples R China
2.Minist Educ, Key Lab Mol Cardiol, Beijing, Peoples R China
3.Peking Univ, Dept Pediat, Hosp 1, Beijing 100871, Peoples R China
4.Univ Calif San Diego, La Jolla, CA 92093 USA
5.Peking Univ, Hosp 1, Dept Med Stat, Beijing 100871, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Lin, Jing,Han, Zhenhui,Li, Hongxia,et al. Plasma C-Type Natriuretic Peptide as a Predictor for Therapeutic Response to Metoprolol in Children with Postural Tachycardia Syndrome[J]. PLOS ONE,2015,10(3).
APA Lin, Jing.,Han, Zhenhui.,Li, Hongxia.,Chen, Selena Ying.,Li, Xueying.,...&Jin, Hongfang.(2015).Plasma C-Type Natriuretic Peptide as a Predictor for Therapeutic Response to Metoprolol in Children with Postural Tachycardia Syndrome.PLOS ONE,10(3).
MLA Lin, Jing,et al."Plasma C-Type Natriuretic Peptide as a Predictor for Therapeutic Response to Metoprolol in Children with Postural Tachycardia Syndrome".PLOS ONE 10.3(2015).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lin, Jing]的文章
[Han, Zhenhui]的文章
[Li, Hongxia]的文章
百度学术
百度学术中相似的文章
[Lin, Jing]的文章
[Han, Zhenhui]的文章
[Li, Hongxia]的文章
必应学术
必应学术中相似的文章
[Lin, Jing]的文章
[Han, Zhenhui]的文章
[Li, Hongxia]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。