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学科主题基础医学
Reduced Expression of Argininosuccinate Lyase is Closely Associated With Postresectional Survival in Hepatocellular Carcinoma: An Immunohistochemistry Study of 61 Cases
Yang, Hua1; Zhai, Guojun3; Ji, Xiaoxu4; Su, Jing2; Lin, Ming1
关键词Argininosuccinate Lyase (Asl) Immunohistochemistry Hcc Prognosis Survival
刊名APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
2012-12-01
20期:6页:602-606
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
研究领域[WOS]Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
关键词[WOS]ARGININE DEIMINASE TREATMENT
英文摘要

Argininosuccinate lyase (ASL) is an important enzyme in the hepatic urea cycle, and catalyzes the reversible reaction of argininosuccinate to arginine and fumarate. Its expression is significantly reduced in some hepatocellular carcinomas (HCC). In this study, we aimed to investigate the correlation of reduced ASL expression and clinicopathologic features and prognosis in HCC patients. Immunohistochemistry was used to determine the expression of ASL in HCC tissues from 61 patients who had undergone hepatic tumor resection. The correlation of ASL expression in HCC with background liver status, viral status, tumor size, portal vein invasion, histopathologic differentiation, early tumor recurrence, sex, and age were assessed with the chi(2) test. Patient survival and survival differences were determined by the Kaplan-Meier method and log-rank test. Cox regression (proportional hazard model) was used for multivariate analysis of prognostic factors. Strong positive staining was found in 39/61 HCCs and normal liver tissues, and reduced ASL staining was found in 22/61 HCCs (36.1%). Patients with low ASL expression had a significantly poorer overall survival and disease-free survival (both P < 0.001). Reduced ASL expression in carcinoma tissues was also significantly associated with the tumor-node-metastasis stage and early tumor recurrence, and histopathologic differentiation and portal vein invasion (P < 0.05). Cox regression analysis showed that ASL is an independent prognostic marker for HCC. Therefore, reduced ASL expression may be a novel maker for poor prognosis in HCC patients.

语种英语
WOS记录号WOS:000311876900011
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57451
专题北京大学基础医学院_细胞生物学系
北京大学基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Intervent Radiol & Vasc Surg, Beijing 100191, Peoples R China
4.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China
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GB/T 7714
Yang, Hua,Zhai, Guojun,Ji, Xiaoxu,et al. Reduced Expression of Argininosuccinate Lyase is Closely Associated With Postresectional Survival in Hepatocellular Carcinoma: An Immunohistochemistry Study of 61 Cases[J]. APPLIED IMMUNOHISTOCHEMISTRY &amp; MOLECULAR MORPHOLOGY,2012,20(6):602-606.
APA Yang, Hua,Zhai, Guojun,Ji, Xiaoxu,Su, Jing,&Lin, Ming.(2012).Reduced Expression of Argininosuccinate Lyase is Closely Associated With Postresectional Survival in Hepatocellular Carcinoma: An Immunohistochemistry Study of 61 Cases.APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY,20(6),602-606.
MLA Yang, Hua,et al."Reduced Expression of Argininosuccinate Lyase is Closely Associated With Postresectional Survival in Hepatocellular Carcinoma: An Immunohistochemistry Study of 61 Cases".APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 20.6(2012):602-606.
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