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学科主题: 公共卫生
题名:
The rs2237892 Polymorphism in KCNQ1 Influences Gestational Diabetes Mellitus and Glucose Levels: A Case-Control Study and Meta-Analysis
作者: Ao, Deng1,2; Wang, Hai-jun1,2; Wang, Li-fang1,2; Song, Jie-yun1,2; Yang, Hui-xia3; Wang, Yan1,2
刊名: PLOS ONE
发表日期: 2015-06-03
DOI: 10.1371/journal.pone.0128901
卷: 10, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: CHINESE WOMEN ; KOREAN POPULATION ; ASSOCIATION ; RISK ; VARIANTS ; PREGNANCY ; SUSCEPTIBILITY ; HYPERGLYCEMIA ; LOAD
英文摘要:

Objective

Recent genetic studies have shown that potassium voltage-gated channel, KQT-like subfamily, member1 (KCNQ1) gene is related to gestational diabetes mellitus (GDM). However, studies for the rs2237892 polymorphism in KCNQ1 and GDM remain conflicting in Asians. Furthermore, associations of this polymorphism with glucose levels during oral glucose tolerance test (OGTT) have not been described in Chinese pregnant women. The present study aimed to provide evidence for the associations of rs2237892 in KCNQ1 with GDM and glucose levels, and to systematically evaluate the effect of rs2237892 on GDM in Asians.

Methods

A case-control study on 562 women with GDM and 453 controls was conducted in Beijing, China. The association of rs2237892 with risk of GDM was analyzed using logistic regression. The associations with quantitative glucose levels were assessed using linear regression models. A meta-analysis including the present case-control study and four previously published reports in Asians was conducted.

Results

The rs2237892 polymorphism in KCNQ1 was associated with GDM (OR (95% CI) = 1.99 (1.26-3.15)). Additionally, the polymorphism was associated with levels of 1h and 2h glucose during OGTT. The pre-pregnancy BMI, age and genotypes of KCNQ1 polymorphism were independent risk factors of GDM. Subsequently, we performed a meta-analysis in Asians. In total, C-allele carriers of rs2237892 polymorphism had a 50% higher risk for GDM (OR (95% CI) = 1.50(1.15-1.78)).

Conclusion

The study demonstrated for the first time that the KCNQ1 rs2237892 polymorphism was associated with GDM and glucose levels in Chinese women. The study provides systematic evidence for the association between this polymorphism and GDM in Asians.

语种: 英语
所属项目编号: 20120001110014
项目资助者: Specialized Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000355700700129
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57457
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Minist Hlth, Key Lab Reprod Hlth, Beijing, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Child Adolescent & Womens Hlth, Beijing 100871, Peoples R China
3.Peking Univ, Dept Obstet & Gynecol, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Ao, Deng,Wang, Hai-jun,Wang, Li-fang,et al. The rs2237892 Polymorphism in KCNQ1 Influences Gestational Diabetes Mellitus and Glucose Levels: A Case-Control Study and Meta-Analysis[J]. PLOS ONE,2015,10(6).
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