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学科主题: 临床医学
题名:
Eradication of H pylori infection in a rural population: One-day quadruple therapy versus 7-day triple therapy
作者: Zhang, Lian; Shen, Lin; Ma, Jun-Ling; Pan, Kai-Feng; Liu, Wei-Dong; Li, Jie; Xiao, Shu-Dong; Lin, San-Ren; Classen, Meinhard; You, Wei-Cheng
关键词: eradication ; H pylori infection ; quadruple therapy ; triple therapy
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2006-06-28
卷: 12, 期:24, 页:3915-3918
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: PRECANCEROUS GASTRIC-LESIONS ; HIGH-RISK ; CHINESE POPULATION ; CANCER ; MANAGEMENT ; RESISTANCE ; TRIAL ; ULCER
英文摘要:

Aim: To compare the one-day quadruple therapy with a standard 7-d triple therapy for H pylori eradication in a rural population of China.

Methods: A total of 396 patients with C-13-urea breath test positive for H pylori were assigned into two groups: 239 patients received one-day quadruple therapy (amoxicillin 2000 mg qid; metronidazole 500 mg qid; bismuth citrate 900 mg qid and lansoprazole 60 mg once daily) and 157 patients received 7-d standard triple therapy (amoxicillin 1000 mg bid; clarithromycin 500 mg bid and lansoprazole 30 mg bid). All the patients underwent a C-13-UBT to assess the eradication of H pylori infection six weeks after treatment.

Results: Two hundred and twenty-nine patients completed the one-day therapy (95.8%) and 148 patients completed the 7-d therapy (94.2%). The one-day therapy eradicated H pylori infection in 64 patients (27.95%). In contrast, 103 patients (69.59%) were H-pylori negative after the 7-d therapy (P<0.01).

Conclusion: This pilot study suggests there is no beneficial effect of the one-day therapy in treatment H pylori infection compared with the 7-d standard therapy. (C) 2006 The WJG Press. All rights reserved.

语种: 英语
WOS记录号: WOS:000239997600023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57468
Appears in Collections:北京大学临床肿瘤学院_流行病学研究室_期刊论文

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作者单位: 1.Tech Univ Munich, D-8000 Munich, Germany
2.Linqu Publ Hlth Bur, Shandong 262600, Peoples R China
3.Shanghai Inst Digest Dis, Shanghai, Peoples R China
4.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
5.Peking Univ, Sch Oncol, Dept Canc Epidemiol, Beijing Canc Hosp & Inst, Beijing 100036, Peoples R China
6.Peking Univ, Sch Oncol, Dept Internal Med, Beijing Canc Hosp & Inst, Beijing 100036, Peoples R China

Recommended Citation:
Zhang, Lian,Shen, Lin,Ma, Jun-Ling,et al. Eradication of H pylori infection in a rural population: One-day quadruple therapy versus 7-day triple therapy[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2006,12(24):3915-3918.
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