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Leukemia inhibitory factor is dysregulated in the endometrium and uterine flushing fluid of patients with adenomyosis during implantation window
Xiao, Yu; Sun, Xiao; Yang, Xiuli; Zhang, Jun; Xue, Qing; Cai, Bocen; Zhou, Yingfang
关键词Leukemia Inhibitory Factor (Lif) Adenomyosis Endometriosis Implantation Window
刊名FERTILITY AND STERILITY
2010-06-01
DOI10.1016/j.fertnstert.2009.03.012
94期:1页:85-89
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
资助者Beijing Municipal Science and Technology Commission ; Beijing Municipal Science and Technology Commission
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]EMBRYO IMPLANTATION ; UNEXPLAINED INFERTILITY ; FACTOR LIF ; WOMEN ; INTERLEUKIN-11 ; RECEPTOR ; UTERUS ; MODEL
英文摘要

Objective: To determine whether the expression of leukemia inhibitory factor during the implantation window in endometrial tissue and uterine flushing fluid of patients with adenomyosis differs from that of healthy fertile women.

Design: Experimental study using endometrial tissue and uterine flushing fluid. Setting: Peking University First Hospital, People′s Republic of China.

Patient(s): There were 28 patients with adenomyosis and 27 control fertile women.

Intervention(s): Uterine flushing fluid and endometrial samples were collected during the implantation window, defined as 7 to 9 days after ovulation.

Main Outcome Measure(s): Leukemia inhibitory factor levels in uterine flushing fluid were measured by enzyme-linked immunosorbent assay. Leukemia inhibitory factor messenger RNA expression in eutopic endometrium was quantified by real-time reverse transcriptase polymerase chain reaction. Leukemia inhibitory factor protein expression was evaluated with semiquantitative immunohistochemistry.

Result(s): Leukemia inhibitory factor levels were significantly lower in the uterine flushing fluid of patients with adenomyosis with a history of infertility. Leukemia inhibitory factor messenger RNA and protein also were significantly lower in patients with adenomyosis, compared with control. Leukemia inhibitory factor immunostaining intensity was significantly lower in patients with adenomyosis, compared with control.

Conclusion(s): Leukemia inhibitory factor is dysregulated in the endometrium and uterine flushing fluid of women with adenomyosis during the implantation window. (Fertil Steril (R) 2010;94:85-9. (C) 2010 by American Society for Reproductive Medicine.)

语种英语
所属项目编号HO30930040230
资助者Beijing Municipal Science and Technology Commission ; Beijing Municipal Science and Technology Commission
WOS记录号WOS:000278858200015
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57471
专题北京大学第一临床医学院
作者单位Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Xiao, Yu,Sun, Xiao,Yang, Xiuli,et al. Leukemia inhibitory factor is dysregulated in the endometrium and uterine flushing fluid of patients with adenomyosis during implantation window[J]. FERTILITY AND STERILITY,2010,94(1):85-89.
APA Xiao, Yu.,Sun, Xiao.,Yang, Xiuli.,Zhang, Jun.,Xue, Qing.,...&Zhou, Yingfang.(2010).Leukemia inhibitory factor is dysregulated in the endometrium and uterine flushing fluid of patients with adenomyosis during implantation window.FERTILITY AND STERILITY,94(1),85-89.
MLA Xiao, Yu,et al."Leukemia inhibitory factor is dysregulated in the endometrium and uterine flushing fluid of patients with adenomyosis during implantation window".FERTILITY AND STERILITY 94.1(2010):85-89.
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