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学科主题: 临床医学
题名:
Leukemia inhibitory factor is dysregulated in the endometrium and uterine flushing fluid of patients with adenomyosis during implantation window
作者: Xiao, Yu; Sun, Xiao; Yang, Xiuli; Zhang, Jun; Xue, Qing; Cai, Bocen; Zhou, Yingfang
关键词: Leukemia inhibitory factor (LIF) ; adenomyosis ; endometriosis ; implantation window
刊名: FERTILITY AND STERILITY
发表日期: 2010-06-01
DOI: 10.1016/j.fertnstert.2009.03.012
卷: 94, 期:1, 页:85-89
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: EMBRYO IMPLANTATION ; UNEXPLAINED INFERTILITY ; FACTOR LIF ; WOMEN ; INTERLEUKIN-11 ; RECEPTOR ; UTERUS ; MODEL
英文摘要:

Objective: To determine whether the expression of leukemia inhibitory factor during the implantation window in endometrial tissue and uterine flushing fluid of patients with adenomyosis differs from that of healthy fertile women.

Design: Experimental study using endometrial tissue and uterine flushing fluid. Setting: Peking University First Hospital, People′s Republic of China.

Patient(s): There were 28 patients with adenomyosis and 27 control fertile women.

Intervention(s): Uterine flushing fluid and endometrial samples were collected during the implantation window, defined as 7 to 9 days after ovulation.

Main Outcome Measure(s): Leukemia inhibitory factor levels in uterine flushing fluid were measured by enzyme-linked immunosorbent assay. Leukemia inhibitory factor messenger RNA expression in eutopic endometrium was quantified by real-time reverse transcriptase polymerase chain reaction. Leukemia inhibitory factor protein expression was evaluated with semiquantitative immunohistochemistry.

Result(s): Leukemia inhibitory factor levels were significantly lower in the uterine flushing fluid of patients with adenomyosis with a history of infertility. Leukemia inhibitory factor messenger RNA and protein also were significantly lower in patients with adenomyosis, compared with control. Leukemia inhibitory factor immunostaining intensity was significantly lower in patients with adenomyosis, compared with control.

Conclusion(s): Leukemia inhibitory factor is dysregulated in the endometrium and uterine flushing fluid of women with adenomyosis during the implantation window. (Fertil Steril (R) 2010;94:85-9. (C) 2010 by American Society for Reproductive Medicine.)

语种: 英语
所属项目编号: HO30930040230
项目资助者: Beijing Municipal Science and Technology Commission
WOS记录号: WOS:000278858200015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57471
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China

Recommended Citation:
Xiao, Yu,Sun, Xiao,Yang, Xiuli,et al. Leukemia inhibitory factor is dysregulated in the endometrium and uterine flushing fluid of patients with adenomyosis during implantation window[J]. FERTILITY AND STERILITY,2010,94(1):85-89.
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