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学科主题: 临床医学
题名:
A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population
作者: Chen, Jing; Wang, Wei; Li, Xiaoguang; Xu, Jie
关键词: Meta-analysis ; IL28B ; rs12979680 ; rs8099917 ; HBV ; Infection susceptibility
刊名: BMC GASTROENTEROLOGY
发表日期: 2015-05-12
DOI: 10.1186/s12876-015-0286-2
卷: 15
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: INDUCED VIRAL CLEARANCE ; CHINESE HAN POPULATION ; GENETIC-VARIATION ; INTERLEUKIN 28B ; C VIRUS
英文摘要:

Background: Several association studies with small sample sizes of two SNPs in IL28BB (rs12979860 and rs8099917) showed inconsistent results, so in this study, we aim to evaluate the association between the two SNPs and infection susceptibility of Hepatitis B Virus (HBV) in Asian population, especially in Chinese population by meta-analysis.

Methods: Search the relevant published papers and perform meta-analysis respectively on IL28B (rs12979860 and rs8099917) in Asian population and Chinese population under an additive genetic model by STATA11.0.

Results: The pooled odds ratios (OR) of rs12979860 are 0.79 (95% CI, 0.53-1.18; P = 0.25, I-2 = 63.2%) and 1.62 (95% CI, 1.04-2.51; P = 0.033, I-2 = 54.3%) respectively in Asian population and Chinese population analysis. The pooled OR of rs8099917 are 1.05 (95% CI, 0.93-1.19; P = 0.44, I-2 = 43.3%) and 0.97 (95% CI, 0.84-1.23; P = 0.726, I-2 = 15.6%) respectively in Asian population and Chinese population analysis.

Conclusion: Our study demonstrated that T allele of rs12979680 can increase the risk of HBV infection in Chinese population but not Asian population under an additive genetic model. There is no association between rs8099917 and HBV infection in Chinese population and Asian population.

语种: 英语
WOS记录号: WOS:000357250300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57472
Appears in Collections:北京大学第三临床医学院_感染疾病科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Infect Dis, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Jing,Wang, Wei,Li, Xiaoguang,et al. A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population[J]. BMC GASTROENTEROLOGY,2015,15.
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