IR@PKUHSC  > 北京大学第三临床医学院  > 感染疾病科
学科主题临床医学
A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population
Chen, Jing; Wang, Wei; Li, Xiaoguang; Xu, Jie
关键词Meta-analysis Il28b Rs12979680 Rs8099917 Hbv Infection Susceptibility
刊名BMC GASTROENTEROLOGY
2015-05-12
DOI10.1186/s12876-015-0286-2
15
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]INDUCED VIRAL CLEARANCE ; CHINESE HAN POPULATION ; GENETIC-VARIATION ; INTERLEUKIN 28B ; C VIRUS
英文摘要

Background: Several association studies with small sample sizes of two SNPs in IL28BB (rs12979860 and rs8099917) showed inconsistent results, so in this study, we aim to evaluate the association between the two SNPs and infection susceptibility of Hepatitis B Virus (HBV) in Asian population, especially in Chinese population by meta-analysis.

Methods: Search the relevant published papers and perform meta-analysis respectively on IL28B (rs12979860 and rs8099917) in Asian population and Chinese population under an additive genetic model by STATA11.0.

Results: The pooled odds ratios (OR) of rs12979860 are 0.79 (95% CI, 0.53-1.18; P = 0.25, I-2 = 63.2%) and 1.62 (95% CI, 1.04-2.51; P = 0.033, I-2 = 54.3%) respectively in Asian population and Chinese population analysis. The pooled OR of rs8099917 are 1.05 (95% CI, 0.93-1.19; P = 0.44, I-2 = 43.3%) and 0.97 (95% CI, 0.84-1.23; P = 0.726, I-2 = 15.6%) respectively in Asian population and Chinese population analysis.

Conclusion: Our study demonstrated that T allele of rs12979680 can increase the risk of HBV infection in Chinese population but not Asian population under an additive genetic model. There is no association between rs8099917 and HBV infection in Chinese population and Asian population.

语种英语
WOS记录号WOS:000357250300001
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57472
专题北京大学第三临床医学院_感染疾病科
北京大学第二临床医学院_骨肿瘤科
作者单位Peking Univ, Hosp 3, Dept Infect Dis, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chen, Jing,Wang, Wei,Li, Xiaoguang,et al. A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population[J]. BMC GASTROENTEROLOGY,2015,15.
APA Chen, Jing,Wang, Wei,Li, Xiaoguang,&Xu, Jie.(2015).A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population.BMC GASTROENTEROLOGY,15.
MLA Chen, Jing,et al."A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population".BMC GASTROENTEROLOGY 15(2015).
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