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学科主题: 药物依赖
题名:
Effects of beta-adrenergic receptor blockade on drug-related memory reconsolidation in abstinent heroin addicts
作者: Zhao, Li-Yan; Sun, Li-Li; Shi, Jie; Li, Peng; Zhang, Yan; Lu, Lin
关键词: beta-Adrenergic receptor antagonist ; Heroin-related memory ; Addiction ; Reconsolidation ; Reactivation
刊名: DRUG AND ALCOHOL DEPENDENCE
发表日期: 2011-11-01
DOI: 10.1016/j.drugalcdep.2011.03.025
卷: 118, 期:2-3, 页:224-229
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Substance Abuse ; Psychiatry
研究领域[WOS]: Substance Abuse ; Psychiatry
关键词[WOS]: HEALTHY-YOUNG MEN ; BASOLATERAL AMYGDALA ; PSYCHOSOCIAL STRESS ; PROTEIN-SYNTHESIS ; PLACE PREFERENCE ; RETRIEVAL ; CONSOLIDATION ; FEAR ; REACTIVATION ; PROPRANOLOL
英文摘要:

Rationale and objective: The reactivation of a consolidated memory can return it to a labile state, a process referred to as reconsolidation. A previous study showed that oral administration of the beta-adrenergic receptor antagonist propranolol before memory reactivation in humans erased the behavioral expression of the fear memory 24 h later. In this study, we investigated whether propranolol impairs the drug-related memory by disrupting the reconsolidation process in heroin addicts.

Methods: Seventy abstinent heroin addicts learned a word list (including 10 heroin-related positive words, 10 heroin-related negative words, and 10 neutral words) on day 1. Participants orally administered the beta-adrenergic receptor antagonist propranolol or placebo before retrieval of the word list on day 2. Free recall of the word list and other psychological and physical responses were assessed on day 3.

Results: Oral administration of propranolol before reactivation of the word list impaired reconsolidation of drug-related positive and negative but not neutral words in abstinent heroin addicts, and these impairments critically depended on reactivation of the word list.

Conclusions: This study extends earlier reports that a p-adrenergic receptor antagonist affects the drug-related memory reconsolidation process. Our findings may have important implications for the understanding and treatment of persistent and abnormal drug-related memories in abstinent heroin addicts. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009CB522000 ; 31070958 ; 81071079 ; 7091003 ; 7092058
项目资助者: National Basic Research Program of China ; Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality
WOS记录号: WOS:000296173800020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57475
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Zhao, Li-Yan,Sun, Li-Li,Shi, Jie,et al. Effects of beta-adrenergic receptor blockade on drug-related memory reconsolidation in abstinent heroin addicts[J]. DRUG AND ALCOHOL DEPENDENCE,2011,118(2-3):224-229.
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