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Effects of beta-adrenergic receptor blockade on drug-related memory reconsolidation in abstinent heroin addicts
Zhao, Li-Yan; Sun, Li-Li; Shi, Jie; Li, Peng; Zhang, Yan; Lu, Lin
关键词Beta-adrenergic Receptor Antagonist Heroin-related Memory Addiction Reconsolidation Reactivation
刊名DRUG AND ALCOHOL DEPENDENCE
2011-11-01
DOI10.1016/j.drugalcdep.2011.03.025
118期:2-3页:224-229
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Substance Abuse ; Psychiatry
研究领域[WOS]Substance Abuse ; Psychiatry
关键词[WOS]HEALTHY-YOUNG MEN ; BASOLATERAL AMYGDALA ; PSYCHOSOCIAL STRESS ; PROTEIN-SYNTHESIS ; PLACE PREFERENCE ; RETRIEVAL ; CONSOLIDATION ; FEAR ; REACTIVATION ; PROPRANOLOL
英文摘要

Rationale and objective: The reactivation of a consolidated memory can return it to a labile state, a process referred to as reconsolidation. A previous study showed that oral administration of the beta-adrenergic receptor antagonist propranolol before memory reactivation in humans erased the behavioral expression of the fear memory 24 h later. In this study, we investigated whether propranolol impairs the drug-related memory by disrupting the reconsolidation process in heroin addicts.

Methods: Seventy abstinent heroin addicts learned a word list (including 10 heroin-related positive words, 10 heroin-related negative words, and 10 neutral words) on day 1. Participants orally administered the beta-adrenergic receptor antagonist propranolol or placebo before retrieval of the word list on day 2. Free recall of the word list and other psychological and physical responses were assessed on day 3.

Results: Oral administration of propranolol before reactivation of the word list impaired reconsolidation of drug-related positive and negative but not neutral words in abstinent heroin addicts, and these impairments critically depended on reactivation of the word list.

Conclusions: This study extends earlier reports that a p-adrenergic receptor antagonist affects the drug-related memory reconsolidation process. Our findings may have important implications for the understanding and treatment of persistent and abnormal drug-related memories in abstinent heroin addicts. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000296173800020
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57475
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
北京大学精神卫生研究所_精神科
作者单位Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
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GB/T 7714
Zhao, Li-Yan,Sun, Li-Li,Shi, Jie,et al. Effects of beta-adrenergic receptor blockade on drug-related memory reconsolidation in abstinent heroin addicts[J]. DRUG AND ALCOHOL DEPENDENCE,2011,118(2-3):224-229.
APA Zhao, Li-Yan,Sun, Li-Li,Shi, Jie,Li, Peng,Zhang, Yan,&Lu, Lin.(2011).Effects of beta-adrenergic receptor blockade on drug-related memory reconsolidation in abstinent heroin addicts.DRUG AND ALCOHOL DEPENDENCE,118(2-3),224-229.
MLA Zhao, Li-Yan,et al."Effects of beta-adrenergic receptor blockade on drug-related memory reconsolidation in abstinent heroin addicts".DRUG AND ALCOHOL DEPENDENCE 118.2-3(2011):224-229.
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