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学科主题: 基础医学
题名:
Adiponectin and Interleukin-6 in Inflammation-Associated Disease
作者: Li, Li; Wu, Li-Ling1; Litwack, G
刊名: ADIPONECTIN
发表日期: 2012
DOI: 10.1016/B978-0-12-398313-8.00014-2
卷: 90, 页:375-395
收录类别: BSCI ; SCI
文章类型: Book Chapter
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]: ACTIVATED PROTEIN-KINASE ; CORONARY-ARTERY-DISEASE ; HIGH-MOLECULAR-WEIGHT ; ADIPOSE-SPECIFIC PROTEIN ; TYPE-2 DIABETIC-PATIENTS ; HEPATIC INSULIN ACTION ; TUMOR-NECROSIS-FACTOR ; SMOOTH-MUSCLE CELL ; PLASMA ADIPONECTIN ; KAPPA-B
英文摘要:

Numerous lines of evidence implicate a role for adipose tissue in the development of a systemic inflammatory state that contributes to metabolic, cardiovascular, and autoimmune disorders. Serum levels of adiponectin, a cytokine that is mainly produced by adipocytes, are paradoxically decreased in individuals with obesity, type 2 diabetes, and cardiovascular disease compared with healthy individuals. Mounting experimental data have revealed that adiponectin exhibits beneficial effects on energy homeostasis and cardiovascular functions that are attributed to its direct modulation of a proinflammatory factor, interleukin-6. However, some recent studies indicate that adiponectin appears to function as an inducer of proinflammatory factors and the elevated adiponectin level aggravates inflammation response in autoimmune disease. In this review, we focus on the action of adiponectin in chronic inflammation-associated metabolic, cardiovascular, and autoimmune disorders. In particular, we discuss the interaction between adiponectin and interleukin-6 in adipocytes and cardiovascular cells.

语种: 英语
WOS记录号: WOS:000310243000014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57481
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100871, Peoples R China
2.Peking Univ, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Li, Li,Wu, Li-Ling,Litwack, G. Adiponectin and Interleukin-6 in Inflammation-Associated Disease[J]. ADIPONECTIN,2012,90:375-395.
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