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学科主题基础医学
Adiponectin and Interleukin-6 in Inflammation-Associated Disease
Li, Li; Wu, Li-Ling1; Litwack, G
刊名ADIPONECTIN
2012
DOI10.1016/B978-0-12-398313-8.00014-2
90页:375-395
收录类别BSCI ; SCI
文章类型Book Chapter
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]ACTIVATED PROTEIN-KINASE ; CORONARY-ARTERY-DISEASE ; HIGH-MOLECULAR-WEIGHT ; ADIPOSE-SPECIFIC PROTEIN ; TYPE-2 DIABETIC-PATIENTS ; HEPATIC INSULIN ACTION ; TUMOR-NECROSIS-FACTOR ; SMOOTH-MUSCLE CELL ; PLASMA ADIPONECTIN ; KAPPA-B
英文摘要

Numerous lines of evidence implicate a role for adipose tissue in the development of a systemic inflammatory state that contributes to metabolic, cardiovascular, and autoimmune disorders. Serum levels of adiponectin, a cytokine that is mainly produced by adipocytes, are paradoxically decreased in individuals with obesity, type 2 diabetes, and cardiovascular disease compared with healthy individuals. Mounting experimental data have revealed that adiponectin exhibits beneficial effects on energy homeostasis and cardiovascular functions that are attributed to its direct modulation of a proinflammatory factor, interleukin-6. However, some recent studies indicate that adiponectin appears to function as an inducer of proinflammatory factors and the elevated adiponectin level aggravates inflammation response in autoimmune disease. In this review, we focus on the action of adiponectin in chronic inflammation-associated metabolic, cardiovascular, and autoimmune disorders. In particular, we discuss the interaction between adiponectin and interleukin-6 in adipocytes and cardiovascular cells.

语种英语
WOS记录号WOS:000310243000014
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57481
专题北京大学基础医学院_心血管所
北京大学基础医学院
作者单位1.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100871, Peoples R China
2.Peking Univ, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Li,Wu, Li-Ling,Litwack, G. Adiponectin and Interleukin-6 in Inflammation-Associated Disease[J]. ADIPONECTIN,2012,90:375-395.
APA Li, Li,Wu, Li-Ling,&Litwack, G.(2012).Adiponectin and Interleukin-6 in Inflammation-Associated Disease.ADIPONECTIN,90,375-395.
MLA Li, Li,et al."Adiponectin and Interleukin-6 in Inflammation-Associated Disease".ADIPONECTIN 90(2012):375-395.
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