IR@PKUHSC  > 北京大学第三临床医学院  > 消化科
学科主题临床医学
Significance of decreased apoptosis, role of Bid expression and Bcl-Xl/Bid ratio in human jejunal stromal tumors
Gao, Chun1,2; Guo, Wen-Juan1,2; Wang, Ai-Ying1
关键词Stromal Tumors Jejunum Apoptosis Bid Bcl-xl Bid Ratio
刊名APMIS
2012-03-01
DOI10.1111/j.1600-0463.2011.02822.x
120期:3页:171-181
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Microbiology ; Pathology
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Immunology ; Microbiology ; Pathology
关键词[WOS]CELL-DEATH ; PROTEINS ; BAX ; PATHOGENESIS ; REGULATORS ; MESYLATE ; THERAPY ; CANCER
英文摘要

Given that the studies on human small intestinal stromal tumors are very limited, our study was designed to determine the significance of apoptosis, the role of some apoptosis-related proteins, including Bax, Bad, Bid, Bcl-2, Bcl-Xl, and Bcl-W, in jejunal stromal tumors (JST). For this purpose, 52 samples were examined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and immunohistochemistry, including 40 cases from normal jejunum and 12 cases from the JST. The results showed that a significantly decreased apoptosis was observed in JST compared with normal jejunum (median of apoptotic index, 0.13% vs 15.17%, p < 0.001). In univariate analysis, statistically significant differences were shown in percentage of positive-expression of Bid (0.0% vs 77.5%, p < 0.001), Bcl-2 (91.7% vs 42.5%, p = 0.003), and Bcl-Xl (75.0% vs 35.0%, p = 0.014), but not in Bax, Bad, and Bcl-W. Moreover, Bcl-Xl was an independent parameter associated with JST by multivariate Logistic analysis. For the role of ratios of anti-apoptotic proteins to pro-apoptotic proteins, Bcl-Xl / Bid ratio was the most preferable index. In conclusion, decreased apoptosis and expression of Bid, increased level of Bcl-Xl may play some important roles in human JST, and Bcl-Xl / Bid ratio may be as a new potentially associated index, although they should be validated in more studies.

语种英语
所属项目编号30571810
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000300447200001
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57482
专题北京大学第三临床医学院_消化科
作者单位1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
2.China Japan Friendship Hosp, Dept Gastroenterol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Gao, Chun,Guo, Wen-Juan,Wang, Ai-Ying. Significance of decreased apoptosis, role of Bid expression and Bcl-Xl/Bid ratio in human jejunal stromal tumors[J]. APMIS,2012,120(3):171-181.
APA Gao, Chun,Guo, Wen-Juan,&Wang, Ai-Ying.(2012).Significance of decreased apoptosis, role of Bid expression and Bcl-Xl/Bid ratio in human jejunal stromal tumors.APMIS,120(3),171-181.
MLA Gao, Chun,et al."Significance of decreased apoptosis, role of Bid expression and Bcl-Xl/Bid ratio in human jejunal stromal tumors".APMIS 120.3(2012):171-181.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Gao, Chun]的文章
[Guo, Wen-Juan]的文章
[Wang, Ai-Ying]的文章
百度学术
百度学术中相似的文章
[Gao, Chun]的文章
[Guo, Wen-Juan]的文章
[Wang, Ai-Ying]的文章
必应学术
必应学术中相似的文章
[Gao, Chun]的文章
[Guo, Wen-Juan]的文章
[Wang, Ai-Ying]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。