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学科主题: 临床医学
题名:
Significance of decreased apoptosis, role of Bid expression and Bcl-Xl/Bid ratio in human jejunal stromal tumors
作者: Gao, Chun1,2; Guo, Wen-Juan1,2; Wang, Ai-Ying1
关键词: Stromal tumors ; jejunum ; apoptosis ; Bid ; Bcl-Xl ; Bid ratio
刊名: APMIS
发表日期: 2012-03-01
DOI: 10.1111/j.1600-0463.2011.02822.x
卷: 120, 期:3, 页:171-181
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Microbiology ; Pathology
研究领域[WOS]: Immunology ; Microbiology ; Pathology
关键词[WOS]: CELL-DEATH ; PROTEINS ; BAX ; PATHOGENESIS ; REGULATORS ; MESYLATE ; THERAPY ; CANCER
英文摘要:

Given that the studies on human small intestinal stromal tumors are very limited, our study was designed to determine the significance of apoptosis, the role of some apoptosis-related proteins, including Bax, Bad, Bid, Bcl-2, Bcl-Xl, and Bcl-W, in jejunal stromal tumors (JST). For this purpose, 52 samples were examined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and immunohistochemistry, including 40 cases from normal jejunum and 12 cases from the JST. The results showed that a significantly decreased apoptosis was observed in JST compared with normal jejunum (median of apoptotic index, 0.13% vs 15.17%, p < 0.001). In univariate analysis, statistically significant differences were shown in percentage of positive-expression of Bid (0.0% vs 77.5%, p < 0.001), Bcl-2 (91.7% vs 42.5%, p = 0.003), and Bcl-Xl (75.0% vs 35.0%, p = 0.014), but not in Bax, Bad, and Bcl-W. Moreover, Bcl-Xl was an independent parameter associated with JST by multivariate Logistic analysis. For the role of ratios of anti-apoptotic proteins to pro-apoptotic proteins, Bcl-Xl / Bid ratio was the most preferable index. In conclusion, decreased apoptosis and expression of Bid, increased level of Bcl-Xl may play some important roles in human JST, and Bcl-Xl / Bid ratio may be as a new potentially associated index, although they should be validated in more studies.

语种: 英语
所属项目编号: 30571810
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000300447200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57482
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
2.China Japan Friendship Hosp, Dept Gastroenterol, Beijing, Peoples R China

Recommended Citation:
Gao, Chun,Guo, Wen-Juan,Wang, Ai-Ying. Significance of decreased apoptosis, role of Bid expression and Bcl-Xl/Bid ratio in human jejunal stromal tumors[J]. APMIS,2012,120(3):171-181.
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