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学科主题基础医学
Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8
Jin, CN; Ding, PG; Wang, Y; Ma, DL
关键词CKLFSF8 EGFR signal internalization
刊名FEBS LETTERS
2005-11-21
DOI10.1016/j.febslet.2005.10.021
579期:28页:6375-6382
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]GROWTH-FACTOR RECEPTOR ; METASTASIS SUPPRESSOR ; TRAFFICKING ; ENDOCYTOSIS ; EXPRESSION ; INTEGRINS ; CLONING ; FAMILY
英文摘要

It is known that chemokine-like factor superfamily 8 (CKLFSF8), a member of the CKLF superfamily, has four putative transmembrane regions and a MARVEL domain. Its structure is similar to TM4SF11 (plasmolipin) and widely distributed in normal tissue. However, its function is not yet known. We show here that CKLFSF8 is associated with the epidermal growth factor receptor (EGFR) and that ectopic expression of CKLFSF8 in several cell lines suppresses EGF-induced cell proliferation, whereas knockdown of CKLFSF8 by siRNA promotes cell proliferation. In cells overexpressing CKLFSF8, the initial activation of EGFR was not affected, but subsequent desensitization of EGF-induced signaling occurred rapidly. This attenuation was correlated with an increased rate of receptor endocytosis. In contrast, knockdown of CKLFSF8 by siCKLFSF8 delayed EGFR endocytosis. These results identify CKLFSF8 as a novel regulator of EGF-induced signaling and indicate that the association of EGFR with four transmembrane proteins is critical for EGFR desensitization. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000233520700014
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57483
专题基础医学院_免疫学系
作者单位1.Peking Univ, Lab Med Immunol, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Human Dis Genom Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Jin, CN,Ding, PG,Wang, Y,et al. Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8[J]. FEBS LETTERS,2005,579(28):6375-6382.
APA Jin, CN,Ding, PG,Wang, Y,&Ma, DL.(2005).Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8.FEBS LETTERS,579(28),6375-6382.
MLA Jin, CN,et al."Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8".FEBS LETTERS 579.28(2005):6375-6382.
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