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学科主题: 基础医学
题名:
Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8
作者: Jin, CN; Ding, PG; Wang, Y; Ma, DL
关键词: CKLFSF8 ; EGFR ; signal internalization
刊名: FEBS LETTERS
发表日期: 2005-11-21
DOI: 10.1016/j.febslet.2005.10.021
卷: 579, 期:28, 页:6375-6382
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: GROWTH-FACTOR RECEPTOR ; METASTASIS SUPPRESSOR ; TRAFFICKING ; ENDOCYTOSIS ; EXPRESSION ; INTEGRINS ; CLONING ; FAMILY
英文摘要:

It is known that chemokine-like factor superfamily 8 (CKLFSF8), a member of the CKLF superfamily, has four putative transmembrane regions and a MARVEL domain. Its structure is similar to TM4SF11 (plasmolipin) and widely distributed in normal tissue. However, its function is not yet known. We show here that CKLFSF8 is associated with the epidermal growth factor receptor (EGFR) and that ectopic expression of CKLFSF8 in several cell lines suppresses EGF-induced cell proliferation, whereas knockdown of CKLFSF8 by siRNA promotes cell proliferation. In cells overexpressing CKLFSF8, the initial activation of EGFR was not affected, but subsequent desensitization of EGF-induced signaling occurred rapidly. This attenuation was correlated with an increased rate of receptor endocytosis. In contrast, knockdown of CKLFSF8 by siCKLFSF8 delayed EGFR endocytosis. These results identify CKLFSF8 as a novel regulator of EGF-induced signaling and indicate that the association of EGFR with four transmembrane proteins is critical for EGFR desensitization. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000233520700014
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57483
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Lab Med Immunol, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Human Dis Genom Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Jin, CN,Ding, PG,Wang, Y,et al. Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8[J]. FEBS LETTERS,2005,579(28):6375-6382.
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