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学科主题: 临床医学
题名:
Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a chinese population
作者: You, WC; Hong, JY; Zhang, L; Pan, KF; Pee, D; Li, JY; Ma, JL; Rothman, N; Caporaso, N; Fraumeni, JF; Xu, GW; Gail, MH
刊名: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
发表日期: 2005-02-01
卷: 14, 期:2, 页:451-458
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Public, Environmental & Occupational Health
研究领域[WOS]: Oncology ; Public, Environmental & Occupational Health
关键词[WOS]: SAMPLE-SIZE CALCULATIONS ; N-NITROSO COMPOUNDS ; ORNITHINE-DECARBOXYLASE ; HELICOBACTER-PYLORI ; STOMACH-CANCER ; ALDEHYDE DEHYDROGENASE-2 ; JAPANESE ALCOHOLICS ; SUSCEPTIBILITY ; ESOPHAGEAL ; GENOTYPES
英文摘要:

There have been few studies of the associations of genetic polymorphisms with precancerous gastric lesions. We conducted a cross-sectional study to compare the prevalences of several genetic polymorphisms in 302 subjects with mild chronic atrophic gastritis with prevalences in 606 subjects with deep intestinal metaplasia or dysplasia. This stratified random sample of 908 subjects was selected and analyzed for genetic polymorphisms from 2,628 individuals who had gastric biopsies with histopathology in 1989 in Linqu County, Shandong Province, China. In subjects with mild chronic atrophic gastritis, the frequencies of the variant (less common) alleles of CYP2E1 RsaI, CYP2E1 DraI, GSTP1, ALDH2, and ODC were, respectively, 0.156, 0.201, 0.189, 0.190, and 0.428. The frequencies of the null genotypes of GSTM1 and GSTT1 in the mild chronic atrophic gastritis group were 0.509 and 0.565, respectively. Comparing mild chronic atrophic gastritis with deep intestinal metaplasia or any degree of dysplasia, we found no statistically significant associations with any genotype from these loci for dominant, additive, or recessive inheritance models. There was no statistically significant evidence of multiplicative interactions between any pair of genotypes based on CYP2E1 RsaI, CYP2E1 DraI, GSTP1, GSTM1, or GSTT1; nor between Helicobacter pylori status and any of these five loci; nor between smoking status and GSTP1, GSTM1, or GSTT1; nor between alcohol consumption and ALDH2. Statistically significant interactions were noted between salt consumption and GSTP1 and between sour pancake consumption and CYP2E1 RsaI. There was, moreover, a statistically significant interaction (odds ratio, 1.78; 95% confidence interval, 1.03-3.08) between CYP2E1 DraI and smoking at least one cigarette per day. A positive but not statistically significant interaction was also seen between CYP2E1 RsaI and smoking status. These polymorphisms do not seem to govern progression from mild chronic atrophic gastritis to advanced precancerous gastric lesions, but the effects of smoking may be accentuated in individuals carrying variants of CYP2E1.

语种: 英语
WOS记录号: WOS:000227113800025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57487
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Inst Canc Res, Beijing 100036, Peoples R China
2.Informat Management Serv Inc, Rockville, MD USA
3.Peking Univ, Sch Oncol, Beijing Canc Hosp, Beijing 100036, Peoples R China
4.Univ Med & Dent New Jersey, Sch Publ Hlth, Piscataway, NJ 08854 USA
5.Natl Canc Inst, Div Canc Epidemiol & Genet, Bethesda, MD USA

Recommended Citation:
You, WC,Hong, JY,Zhang, L,et al. Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a chinese population[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,2005,14(2):451-458.
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