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学科主题: 药学
题名:
Protective effect of a new amide compound from Pu-erh tea on human micro-vascular endothelial cell against cytotoxicity induced by hydrogen peroxide
作者: Zhang, Liang1; Ma, Zhi-Zhong2; Che, Yan-Yun1; Li, Ning1; Tu, Peng-Fei1
关键词: Camellia assamica (Mast.) Chang ; Amide ; 3,4-Dihydroxybenzoic acid ; Human micro-vascular endothelial cell
刊名: FITOTERAPIA
发表日期: 2011-03-01
DOI: 10.1016/j.fitote.2010.10.009
卷: 82, 期:2, 页:267-271
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: GREEN
英文摘要:

A new amide, N-(3,4-dihydroxybenzoyl)-3,4-dihydroxybenzamide (1), was isolated from the Pu-erh tea made with the leaf of Camellia assamica (Mast.) Chang by special fermentation techniques with bacteria and fungus. Its structure was established by means of spectroscopic data analyses, including mass spectrometry and both 1D and 2D NMR spectroscopy. Human micro-vascular endothelial cell (HMEC) injured with H2O2 was used as the model to test protective effect of compound 1 in contrast with other known compounds isolated from Pu-erh tea. These results suggested that compound 1 is a very useful compound to prevent H2O2-induced cell death of HMEC. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2007BAD58804-2
项目资助者: Modern Agriculture Industrial Technology System, Yun Nan Agricultural University
WOS记录号: WOS:000287567800025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57490
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Basic Med Sch, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Liang,Ma, Zhi-Zhong,Che, Yan-Yun,et al. Protective effect of a new amide compound from Pu-erh tea on human micro-vascular endothelial cell against cytotoxicity induced by hydrogen peroxide[J]. FITOTERAPIA,2011,82(2):267-271.
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