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Protective effect of a new amide compound from Pu-erh tea on human micro-vascular endothelial cell against cytotoxicity induced by hydrogen peroxide
Zhang, Liang1; Ma, Zhi-Zhong2; Che, Yan-Yun1; Li, Ning1; Tu, Peng-Fei1
关键词Camellia Assamica (Mast.) Chang Amide Human Micro-vascular Endothelial Cell 3 4-dihydroxybenzoic Acid
刊名FITOTERAPIA
2011-03-01
DOI10.1016/j.fitote.2010.10.009
82期:2页:267-271
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]GREEN
英文摘要

A new amide, N-(3,4-dihydroxybenzoyl)-3,4-dihydroxybenzamide (1), was isolated from the Pu-erh tea made with the leaf of Camellia assamica (Mast.) Chang by special fermentation techniques with bacteria and fungus. Its structure was established by means of spectroscopic data analyses, including mass spectrometry and both 1D and 2D NMR spectroscopy. Human micro-vascular endothelial cell (HMEC) injured with H2O2 was used as the model to test protective effect of compound 1 in contrast with other known compounds isolated from Pu-erh tea. These results suggested that compound 1 is a very useful compound to prevent H2O2-induced cell death of HMEC. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000287567800025
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57490
Collection北京大学药学院
北京大学基础医学院
北京大学药学院_天然药物学系
北京大学第三临床医学院_麻醉科
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Basic Med Sch, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Liang,Ma, Zhi-Zhong,Che, Yan-Yun,et al. Protective effect of a new amide compound from Pu-erh tea on human micro-vascular endothelial cell against cytotoxicity induced by hydrogen peroxide[J]. FITOTERAPIA,2011,82(2):267-271.
APA Zhang, Liang,Ma, Zhi-Zhong,Che, Yan-Yun,Li, Ning,&Tu, Peng-Fei.(2011).Protective effect of a new amide compound from Pu-erh tea on human micro-vascular endothelial cell against cytotoxicity induced by hydrogen peroxide.FITOTERAPIA,82(2),267-271.
MLA Zhang, Liang,et al."Protective effect of a new amide compound from Pu-erh tea on human micro-vascular endothelial cell against cytotoxicity induced by hydrogen peroxide".FITOTERAPIA 82.2(2011):267-271.
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