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学科主题: 临床医学
题名:
Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2
作者: Klupa, T; Malecki, MT; Pezzolesi, M; Ji, LO; Curtis, S; Langefeld, CD; Rich, SS; Warram, JH; Krolewski, AS
刊名: DIABETES
发表日期: 2000-12-01
卷: 49, 期:12, 页:2212-2216
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: SIB PAIRS ; MELLITUS ; LINKAGE ; ONSET ; GENE ; NIDDM ; SCAN ; 20Q
英文摘要:

We previonsly reported suggestive linkage between type 2 diabetes and markers in a region on chromosome 20q using data from a collection of 29 Caucasian families in which type 2 diabetes with middle-age-onset was segregated as an autosomal-dominant disorder. To map more precisely the susceptibility locus (or loci) within this broad region, we increased the family collection and genotyped all families for additional markers, both within the critical region and spaced over the rest of chromosome 20. Altogether 526 individuals (including 241 with diabetes) from the total collection of 43 families were included in the study. All individuals mere genotyped for 23 highly polymorphic markers. Positive evidence for Linkage was found for a 10-cM region on the long arm of chromosome 20q13.1-q13.2 between markers D20S119 and D20S428. The strongest evidence in two-point as well as multipoint linkage analysis (P = 1.8 x 10(-5)) occurred at the position corresponding to marker D20S196. The individuals with diabetes in the seven most strongly linked families had high serum insulin levels during fasting and 2-h post-glucose load periods. me did not find any evidence for linkage between type 2 diabetes and any other region on chromosome 20. In conclusion, our larger and more comprehensive study showed very strong evidence for a susceptibility gene for insulin-resistant type 2 diabetes located on the long arm of chromosome 20 around marker D20S196.

语种: 英语
WOS记录号: WOS:000165573500033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57494
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Jagiellonian Univ, Sch Med, Dept Metab Dis, Krakow, Poland
2.Harvard Univ, Sch Med, Dept Med, Boston, MA USA
3.Joslin Diabet Ctr, Sect Genet & Epidemiol, Div Res, Boston, MA 02215 USA
4.Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27103 USA
5.Beijing Med Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100083, Peoples R China

Recommended Citation:
Klupa, T,Malecki, MT,Pezzolesi, M,et al. Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2[J]. DIABETES,2000,49(12):2212-2216.
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