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学科主题: 临床医学
题名:
Determination of Amphotericin B in Human Cerebrospinal Fluid by LC-MS-MS
作者: Xiong, Xin1,2; Zhai, Suodi1,2; Liu, Fang1,2
关键词: Column liquid chromatography ; Tandem mass spectrometry ; Amphotericin B ; Human cerebrospinal fluid
刊名: CHROMATOGRAPHIA
发表日期: 2009-07-01
DOI: 10.1365/s10337-009-1112-1
卷: 70, 期:1-2, 页:329-332
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: SOLID-PHASE EXTRACTION ; LIQUID-CHROMATOGRAPHY ; HUMAN PLASMA ; QUANTITATION
英文摘要:

A simple, specific and sensitive column liquid chromatography-tandem mass spectrometry method has been developed for the determination of amphotericin B in human cerebrospinal fluid. Samples were prepared by dilution with methanol and quantitated by MS-MS detection in the positive mode. The determination was validated in the concentration range of 0.5-100 ng mL(-1) using 100 mu L of human cerebrospinal fluid. The method was successfully used to support routine therapeutic drug monitoring.

语种: 英语
WOS记录号: WOS:000268055600049
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57500
Appears in Collections:北京大学第三临床医学院_药剂科_期刊论文

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作者单位: 1.Peking Univ, Dept Pharm, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Therapeut Drugs Monitoring & Clin Toxicol Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Xiong, Xin,Zhai, Suodi,Liu, Fang. Determination of Amphotericin B in Human Cerebrospinal Fluid by LC-MS-MS[J]. CHROMATOGRAPHIA,2009,70(1-2):329-332.
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