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学科主题临床医学
Determination of Amphotericin B in Human Cerebrospinal Fluid by LC-MS-MS
Xiong, Xin1,2; Zhai, Suodi1,2; Liu, Fang1,2
关键词Column Liquid Chromatography Tandem Mass Spectrometry Amphotericin b Human Cerebrospinal Fluid
刊名CHROMATOGRAPHIA
2009-07-01
DOI10.1365/s10337-009-1112-1
70期:1-2页:329-332
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]SOLID-PHASE EXTRACTION ; LIQUID-CHROMATOGRAPHY ; HUMAN PLASMA ; QUANTITATION
英文摘要

A simple, specific and sensitive column liquid chromatography-tandem mass spectrometry method has been developed for the determination of amphotericin B in human cerebrospinal fluid. Samples were prepared by dilution with methanol and quantitated by MS-MS detection in the positive mode. The determination was validated in the concentration range of 0.5-100 ng mL(-1) using 100 mu L of human cerebrospinal fluid. The method was successfully used to support routine therapeutic drug monitoring.

语种英语
WOS记录号WOS:000268055600049
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57500
专题北京大学第三临床医学院_药剂科
作者单位1.Peking Univ, Dept Pharm, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Therapeut Drugs Monitoring & Clin Toxicol Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xiong, Xin,Zhai, Suodi,Liu, Fang. Determination of Amphotericin B in Human Cerebrospinal Fluid by LC-MS-MS[J]. CHROMATOGRAPHIA,2009,70(1-2):329-332.
APA Xiong, Xin,Zhai, Suodi,&Liu, Fang.(2009).Determination of Amphotericin B in Human Cerebrospinal Fluid by LC-MS-MS.CHROMATOGRAPHIA,70(1-2),329-332.
MLA Xiong, Xin,et al."Determination of Amphotericin B in Human Cerebrospinal Fluid by LC-MS-MS".CHROMATOGRAPHIA 70.1-2(2009):329-332.
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