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学科主题: 口腔医学
题名:
Effect of Dexmedetomidine on Preventing Agitation and Delirium After Microvascular Free Flap Surgery: A Randomized, Double-Blind, Control Study
作者: Yang, Xudong; Li, Zhenzhen; Gao, Chunyan; Liu, Ruichang
刊名: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
发表日期: 2015-06-01
DOI: 10.1016/j.joms.2015.01.011
卷: 73, 期:6, 页:1065-1072
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: MECHANICALLY VENTILATED PATIENTS ; CRITICALLY-ILL PATIENTS ; POSTOPERATIVE DELIRIUM ; EMERGENCE AGITATION ; REDUCES AGITATION ; CONTROLLED-TRIAL ; SEDATION ; CHILDREN ; SLEEP ; HEAD
英文摘要:

Purpose: To determine whether dexmedetomidine sedation in the postanesthesia care unit (PACU) could decrease agitation and delirium after free flap surgery.

Materials and Methods: Eighty patients were randomly divided into 2 groups. In the experimental group, dexmedetomidine was given at an hourly infusion rate of 0.5 mu g/kg for 1 hour before the operation was completed and continued in the PACU at 0.2 to 0.7 mu g/kg continuously until the next morning. In the control group, normal saline was given during the same periods. Patients in the 2 groups received sufentanil and midazolam for sedation and pain relief when necessary. Agitation was monitored with the Riker Sedation-Agitation Scale in the PACU and delirium was monitored with the Confusion Assessment Method for the Intensive Care Unit for 5 days postoperatively.

Results: The overall incidence of agitation was similar between the 2 groups. However, when the influence of patient shiftingwas excluded, the incidence of agitation in the dexmedetomidine group was apparently lower than that in the control group (10.3 vs 30%; P =.029). No difference was found in the occurrence of delirium between the experimental and control groups (5.1 vs 12.5%; P =.432).

Conclusion: Dexmedetomidine does not change the overall incidence of agitation after free flap surgery; however, it does decrease agitation after PACU admission. It does not prevent delirium within 5 days postoperatively. (C) 2015 American Association of Oral and Maxillofacial Surgeons

语种: 英语
所属项目编号: CSA2012LB003
项目资助者: Libang Anesthesia Science Committee
WOS记录号: WOS:000354577900017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57501
Appears in Collections:北京大学口腔医学院_麻醉科_期刊论文

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作者单位: Peking Univ, Sch & Hosp Stomatol, Dept Anesthesiol, Beijing 100081, Peoples R China

Recommended Citation:
Yang, Xudong,Li, Zhenzhen,Gao, Chunyan,et al. Effect of Dexmedetomidine on Preventing Agitation and Delirium After Microvascular Free Flap Surgery: A Randomized, Double-Blind, Control Study[J]. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,2015,73(6):1065-1072.
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