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学科主题: 临床医学
题名:
Genetic Identification and Risk Factor Analysis of Asymptomatic Bacterial Colonization on Cardiovascular Implantable Electronic Devices
作者: Chu, Xian-Ming1; Li, Bing2; An, Yi1; Li, Xue-Bin3; Guo, Ji-Hong3
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2014
DOI: 10.1155/2014/725163
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: RHYTHM MANAGEMENT DEVICES ; PERMANENT PACEMAKER ; CARDIOVERTER-DEFIBRILLATORS ; STAPHYLOCOCCUS-AUREUS ; INFECTION ; REPLACEMENT ; DIAGNOSIS ; ENDOCARDITIS ; SONICATION ; PREVENTION
英文摘要:

Asymptomatic bacterial colonization of cardiovascular implantable electronic devices (CIEDs) is widespread and increases the risk of clinical CIED infection. The aim of the study was to evaluate the incidence of bacterial colonization of generator pockets in patients without signs of infection and to analyze the relationship with clinical infection and risk factors. From June 2011 to December 2012, 78 patients underwent CIED replacement or upgrade. Exclusion criteria included a clinical diagnosis of CIED infection, bacteremia, or infective endocarditis. All patients were examined for evidence of bacterial 16S rDNA on the device and in the surrounding tissues. Infection cases were recorded during follow-up. The bacterial-positive rate was 38.5% (30 cases); the coagulase-negative Staphylococcus detection rate was the highest (9 cases, 11.5%). Positive bacterial DNA results were obtained from pocket tissue in 23.1% of patients (18 cases), and bacterial DNA was detected on the device in 29.5% of patients (23 cases). During follow-up (median 24.6 months), two patients (6.7%, 2/30) became symptomatic with the same species of microorganism, S. aureus and S. epidermidis. Multivariable logistic regression analysis found that the history of bacterial infection, use of antibiotics, application of antiplatelet drugs, replacement frequency, and renal insufficiency were independent risk factors for asymptomatic bacterial colonization.

语种: 英语
所属项目编号: 81001346 ; 81471546 ; Z121107001012016 ; 2012YD18035 ; J12LL59 ; 47-11
项目资助者: National Natural Science Foundation of China ; Capital Project ; Shandong Project ; Hospital Project
WOS记录号: WOS:000346991400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57502
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Qingdao Univ, Affiliated Hosp, Dept Cardiol, Qingdao 266100, Peoples R China
2.Qingdao Univ, Coll Med, Dept Biol, Qingdao 266021, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Cardiac Electrophysiol, Beijing 100044, Peoples R China

Recommended Citation:
Chu, Xian-Ming,Li, Bing,An, Yi,et al. Genetic Identification and Risk Factor Analysis of Asymptomatic Bacterial Colonization on Cardiovascular Implantable Electronic Devices[J]. BIOMED RESEARCH INTERNATIONAL,2014.
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