IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Genetic Identification and Risk Factor Analysis of Asymptomatic Bacterial Colonization on Cardiovascular Implantable Electronic Devices
Chu, Xian-Ming1; Li, Bing2; An, Yi1; Li, Xue-Bin3; Guo, Ji-Hong3
刊名BIOMED RESEARCH INTERNATIONAL
2014
DOI10.1155/2014/725163
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]RHYTHM MANAGEMENT DEVICES ; PERMANENT PACEMAKER ; CARDIOVERTER-DEFIBRILLATORS ; STAPHYLOCOCCUS-AUREUS ; INFECTION ; REPLACEMENT ; DIAGNOSIS ; ENDOCARDITIS ; SONICATION ; PREVENTION
英文摘要

Asymptomatic bacterial colonization of cardiovascular implantable electronic devices (CIEDs) is widespread and increases the risk of clinical CIED infection. The aim of the study was to evaluate the incidence of bacterial colonization of generator pockets in patients without signs of infection and to analyze the relationship with clinical infection and risk factors. From June 2011 to December 2012, 78 patients underwent CIED replacement or upgrade. Exclusion criteria included a clinical diagnosis of CIED infection, bacteremia, or infective endocarditis. All patients were examined for evidence of bacterial 16S rDNA on the device and in the surrounding tissues. Infection cases were recorded during follow-up. The bacterial-positive rate was 38.5% (30 cases); the coagulase-negative Staphylococcus detection rate was the highest (9 cases, 11.5%). Positive bacterial DNA results were obtained from pocket tissue in 23.1% of patients (18 cases), and bacterial DNA was detected on the device in 29.5% of patients (23 cases). During follow-up (median 24.6 months), two patients (6.7%, 2/30) became symptomatic with the same species of microorganism, S. aureus and S. epidermidis. Multivariable logistic regression analysis found that the history of bacterial infection, use of antibiotics, application of antiplatelet drugs, replacement frequency, and renal insufficiency were independent risk factors for asymptomatic bacterial colonization.

语种英语
WOS记录号WOS:000346991400001
项目编号81001346 ; 81471546 ; Z121107001012016 ; 2012YD18035 ; J12LL59 ; 47-11
资助机构National Natural Science Foundation of China ; Capital Project ; Shandong Project ; Hospital Project
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57502
专题北京大学第二临床医学院
北京大学临床肿瘤学院_药剂科
作者单位1.Qingdao Univ, Affiliated Hosp, Dept Cardiol, Qingdao 266100, Peoples R China
2.Qingdao Univ, Coll Med, Dept Biol, Qingdao 266021, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Cardiac Electrophysiol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Chu, Xian-Ming,Li, Bing,An, Yi,et al. Genetic Identification and Risk Factor Analysis of Asymptomatic Bacterial Colonization on Cardiovascular Implantable Electronic Devices[J]. BIOMED RESEARCH INTERNATIONAL,2014.
APA Chu, Xian-Ming,Li, Bing,An, Yi,Li, Xue-Bin,&Guo, Ji-Hong.(2014).Genetic Identification and Risk Factor Analysis of Asymptomatic Bacterial Colonization on Cardiovascular Implantable Electronic Devices.BIOMED RESEARCH INTERNATIONAL.
MLA Chu, Xian-Ming,et al."Genetic Identification and Risk Factor Analysis of Asymptomatic Bacterial Colonization on Cardiovascular Implantable Electronic Devices".BIOMED RESEARCH INTERNATIONAL (2014).
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