IR@PKUHSC  > 基础医学院  > 生物物理学系
学科主题基础医学
Tumor-derived factors impaired motility and immune functions of dendritic cells through derangement of biophysical characteristics and reorganization of cytoskeleton
Zeng, Zhu; Xu, Xiaofeng; Zhang, Yingyu; Xing, Junjie; Long, Jinhua; Gu, Li; Wang, Xianwei; Sun, Dagong; Ka, Weibo; Yao, Weijuan; Wen, Zongyao; Chien, Shu
关键词dendritic cells (DCs) biophysical characteristics and immune fuctions immune excape mechanism suppressive cytokines tumor microenvironment
刊名CELL MOTILITY AND THE CYTOSKELETON
2007-03-01
DOI10.1002/cm.20175
64期:3页:186-198
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]TRANSFORM INFRARED-SPECTROSCOPY ; MURINE ERYTHROLEUKEMIA-CELLS ; NECROSIS-FACTOR-ALPHA ; ANTIGEN PRESENTATION ; PERIPHERAL-BLOOD ; HEPATOCELLULAR-CARCINOMA ; BREAST-CANCER ; LYMPH-NODES ; MATURATION ; DIFFERENTIATION
英文摘要

The generation and progress of tumors are accompanied with a marked suppression of human immune system. To explore the mechanisms by which tumors escape from immune recognition, we studied the influences of tumor microenvironment on differentiation of dendritic cells (DCs), which play an important role in tumor immunology, by biophysical and immunological methods. It was found that the cytokines derived from tumors caused an increase in osmotic fragility and a decrease in membrane fluidity of DCs, disordering and elevated expression levels of cytoskeleton, and changes of the gene transcriptional levels and energy status of the cells. Moreover, IL-12 production and the expression levels of some surface-marker molecules were also suppressed. These changes led to impaired capabilities of antigen uptake, cell motility and naive T cell activation; the abnormal biophysical characteristics of DCs may be one aspect of the immune escape mechanism of tumor. These results provide insights into the importance of the reconstruction of tumor microenvironment for immunotherapy based on the anti-cancer activities of DCs.

语种英语
WOS记录号WOS:000244379200004
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57513
专题基础医学院_生物物理学系
作者单位1.Peking Univ, Ctr Hlth Sci, Dept Biophys, Beijing 100083, Peoples R China
2.Guiyang Med Coll, Guiyang, Guizhou, Peoples R China
3.Peking Univ, Ctr Hlth Sci, Dept Phys Med, Beijing 100083, Peoples R China
4.Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
5.Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
推荐引用方式
GB/T 7714
Zeng, Zhu,Xu, Xiaofeng,Zhang, Yingyu,et al. Tumor-derived factors impaired motility and immune functions of dendritic cells through derangement of biophysical characteristics and reorganization of cytoskeleton[J]. CELL MOTILITY AND THE CYTOSKELETON,2007,64(3):186-198.
APA Zeng, Zhu.,Xu, Xiaofeng.,Zhang, Yingyu.,Xing, Junjie.,Long, Jinhua.,...&Chien, Shu.(2007).Tumor-derived factors impaired motility and immune functions of dendritic cells through derangement of biophysical characteristics and reorganization of cytoskeleton.CELL MOTILITY AND THE CYTOSKELETON,64(3),186-198.
MLA Zeng, Zhu,et al."Tumor-derived factors impaired motility and immune functions of dendritic cells through derangement of biophysical characteristics and reorganization of cytoskeleton".CELL MOTILITY AND THE CYTOSKELETON 64.3(2007):186-198.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Tumor-derived factor(476KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zeng, Zhu]的文章
[Xu, Xiaofeng]的文章
[Zhang, Yingyu]的文章
百度学术
百度学术中相似的文章
[Zeng, Zhu]的文章
[Xu, Xiaofeng]的文章
[Zhang, Yingyu]的文章
必应学术
必应学术中相似的文章
[Zeng, Zhu]的文章
[Xu, Xiaofeng]的文章
[Zhang, Yingyu]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Tumor-derived factors impaired motility and immune functions .pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。