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学科主题临床医学
Identification of miR-125a-5p as a tumor suppressor of renal cell carcinoma, regulating cellular proliferation, migration and apoptosis
Chen, Duqun1,2,3; Li, Yifan1,2,3; Su, Zhengming1,2,4; Yu, Zuhu1,2,3; Yu, Wenshui1,2,4; Li, Yuchi1,2,4; Gui, Yaoting2; Yang, Shangqi1,2; Lai, Yongqing1,2
关键词Mir-125a-5p Tumor Suppressor Renal Cell Carcinoma
刊名MOLECULAR MEDICINE REPORTS
2015-02-01
DOI10.3892/mmr.2014.2848
11期:2页:1278-1283
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
资助者National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Science and Technology Development Fund Project of Shenzhen ; Shenzhen Science and Technology Project ; National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Science and Technology Development Fund Project of Shenzhen ; Shenzhen Science and Technology Project
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]BREAST-CANCER ; DOWN-REGULATION ; GASTRIC-CANCER ; MICRORNA ; PERTUZUMAB ; SERUM
英文摘要

miR-125a-5p has been previously described as a tumor suppressor in numerous malignancies, however the expression and function of miR-125a-5p in renal cell carcinoma (RCC) remains to be elucidated. In the present study, to explore the potential role of miR-125a-5p in RCC, quantitative polymerase chain reaction was used to determine the expression levels of miR-125a-5p in renal cancer tissues. The influence of miR-125a-5p on cell proliferation, migration and apoptosis was also determined, using an MTT assay, a wound scratch assay and flow cytometry, respectively. The expression of miR-125a-5p was shown to be decreased in RCC and the restoration of miR-125a-5p by synthetic mimics was shown to suppress cell proliferation and migration, and induce apoptosis. The present results indicate that miR-125a-5p may function as a tumor suppressor in RCC. The present study is, to the best of our knowledge, the first to demonstrate the downregulation of miR-125a-5p in RCC, and to show the role it has in affecting cellular proliferation, migration and apoptosis. Further research is needed to define the target genes of miR-125a-5p and explore the potential of miR-125a-5p as a diagnostic or a prognostic biomarker for RCC.

语种英语
所属项目编号81101922 ; A2012584 ; A2013606 ; JCYJ20130402114702124 ; 201302050
资助者National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Science and Technology Development Fund Project of Shenzhen ; Shenzhen Science and Technology Project ; National Natural Science Foundation of China ; Medical Scientific Research Foundation of Guangdong Province of China ; Science and Technology Development Fund Project of Shenzhen ; Shenzhen Science and Technology Project
WOS记录号WOS:000349506400076
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57515
专题北京大学深圳医院_泌尿外科
作者单位1.Peking Univ, Dept Urol, Shenzhen Hosp, Shenzhen 518036, Guangdong, Peoples R China
2.Peking Univ, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen Hosp, Inst Urol Shenzhen PKU HKUST Med Ctr, Shenzhen 518036, Guangdong, Peoples R China
3.Anhui Med Univ, Dept Urol, Hefei 230032, Anhui, Peoples R China
4.Shantou Univ, Dept Urol, Coll Med, Shantou 515041, Guangdon, Peoples R China
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GB/T 7714
Chen, Duqun,Li, Yifan,Su, Zhengming,et al. Identification of miR-125a-5p as a tumor suppressor of renal cell carcinoma, regulating cellular proliferation, migration and apoptosis[J]. MOLECULAR MEDICINE REPORTS,2015,11(2):1278-1283.
APA Chen, Duqun.,Li, Yifan.,Su, Zhengming.,Yu, Zuhu.,Yu, Wenshui.,...&Lai, Yongqing.(2015).Identification of miR-125a-5p as a tumor suppressor of renal cell carcinoma, regulating cellular proliferation, migration and apoptosis.MOLECULAR MEDICINE REPORTS,11(2),1278-1283.
MLA Chen, Duqun,et al."Identification of miR-125a-5p as a tumor suppressor of renal cell carcinoma, regulating cellular proliferation, migration and apoptosis".MOLECULAR MEDICINE REPORTS 11.2(2015):1278-1283.
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